On July 8th, the Transform Tox Testing Challenge organizers will host a workshop in Research Triangle Park, North Carolina to bring together Stage 1 winners, agency experts, and other leaders in the field to discuss the Tox21 and ToxCast programs, the semi-finalist proposals, and feasible expectations for the remainder of the challenge.

The workshop will provide an opportunity to derive criteria and timelines for Stage 2 and 3 of the challenge that make sense to both the solvers and the challenge team and create ongoing networks and collaborations that will strengthen the research field. The workshop is divided into public and closed sessions.

The goal of the challenge is to develop a practical design that will turn existing, commonly used in vitro chemical screening assays into tests competent (e.g. drug metabolizing cytochromes P450) enough to produce physiologically relevant metabolites within cell-based HTS assays which will evaluate both parent chemical and metabolite effects in the assay responses. The successful design will offer information that can be used to review and evaluate HTS assay results, and will also ensure better quality data, transparency, and overall confidence in assay results.

Location: The meeting is being held in the Auditorium (Room C111) at EPA’s Research Triangle Park campus, located at 109 T.W. Alexander Drive, Research Triangle Park, North Carolina 27709.

Remote participation in the public sessions is available here.

For audio, dial (866) 299-3188 and use code 919-541-1522.

Additional information regarding directions, security, and local amenities can be found here.

Planning to bring a laptop computer or camera? Please complete the U.S. EPA Temporary Authorization for Personally Owned Equipment Form prior to arrival.

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Draft Agenda:

Open Session

8:00 – 8:30 a.m. Registration, Coffee, Networking

8:30 – 8:45 a.m. Welcome and Opening Remarks

8:45 – 9:00 a.m. Summit Overview and Objectives

9:00 – 10:15 a.m. Panel: Why the Metabolism Challenge is Important to Solve

10:15 – 10:45 a.m. Stretch Break, Networking

10:45 – 11:45 a.m. Introduction of Challenge Participants and Lightning Round of Challenge Participant Solutions

11:45 – 1:00 p.m. Lunch (Purchased on own at cafeteria – Tables will be reserved for networking)

1:00 – 2:00 p.m. Commercialization Strategies Panel

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Closed Session (by invitation only):

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2:30 – 3:30 p.m. Stage 2 Criteria – Facilitated Brainstorm & Discussion

3:30 – 3:45 p.m. Refreshment/Stretch Break

3:45 – 4:45 p.m. Stage 2 Deliverables – Facilitated Brainstorm & Discussion

4:45 – 5:30 p.m. Workshop Conclusion & Final Thoughts

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Open to All (informal):

6:00 Happy Hour/Dinner – Optional - - EPA will make recommendations