Name: STRAW 2018 - Stroke Translational Research Advancement Workshop
Start: 2018-10-24T08:00:00-04:00
End: 2018-10-25T16:00:00-04:00
Location: Spindletop Hall

STRAW 2018 - Stroke Translational Research Advancement Workshop

SPEAKER INFORMATIONSameer Ansari,MD, PhD is an interventional neuroradiologist/neurointerventional surgeon at Northwestern Memorial Hospital, Associate Professor in the Departments of Radiology, Neurology and Neurosurgery, Northwestern University Feinberg School of Medicine. Dr. Ansari received his medical and doctoral degrees from Jefferson Medical College, Philadelphia, and went on to complete his Diagnostic Radiology residency at the University of Illinois Hospital, Chicago as well as Diagnostic/Interventional Neuroradiology fellowships at the University of Michigan Health System, Ann Arbor. Following faculty positions at the University of Michigan and University of Chicago as Director of the Neurointerventional Surgery program, he transitioned to Northwestern University in 2010. Dr. Ansari specializes in minimally invasive percutaneous and endovascular procedures of the brain, head/neck and spine. His clinical and basic science research interests are predominantly centered on MR imaging based patient selection to stratify risk of various neurovascular pathologies, particularly the molecular pathogenesis and inflammation imaging of intracranial atherosclerotic disease and acute ischemic stroke.Other clinical research interests have investigated the safety and efficacy of coated coils in the embolization of intracranial aneurysms, the role of intracranial stents in the treatment of distal cervical/intracranial dissections, quantitative 4D flow and functional MRI techniques in the assessment of intracranial aneurysms and arteriovenous malformations.  Dr. Ansari is a nationally recognized academic interventional neuroradiologist. He has published numerous peer reviewed scientific papers, national guidelines, reviews and case studies; and has been awarded multiple industry, foundation, and NIH sponsored research grants. He actively participates in the peer review process of several neurointerventional and neurosurgery journals. He is an active member of the Society of Neurointerventional Surgery (SNIS), the American Society of Neuroradiology (ASNR), American University Radiologists (AUR), the American Roentgen Ray Society (ARRS), the Radiological Society of North America (RSNA) and the American College of Radiology (ACR). He serves on the Board of Directors of the SNIS as the Medical Director of the Neurovascular Quality Initiative (NVQI), the national neurointerventional data registry supported by the SNIS Patient Safety Organization and is currently the co-Chair of the Food and Drug Administration’s (FDA) Coordinated Registry Network (CRN) for Devices Used for Acute Ischemic Stroke Intervention (DAISI).Louise McCulloughis the Roy M. and Phyllis Gough Huffington Distinguished Chair and professor of neurology at McGovern Medical School at UTHealth and Chief of Neurology at Memorial Herman Hospital – Texas Medical Center. She is a physician-scientist and a practicing vascular neurologist with clinical expertise in sex/gender disparities, stroke prevention, stroke and aging, acute stroke treatments and outcome assessment. A renowned investigator, she is well recognized for her work in cerebral vascular disease and is known for her research identifying sex differences in cell death pathways during stroke, which are now been shown to be a major factor in the response to an ischemic insult. Working closely with the Society for Women's Health Research (SWHR) and the Office of Research on Women’s Health (ORWH), she was instrumental in the National Institute of Health’s requirement to include female animals in basic and translational studies. Among Dr. McCullough’s many honors and awards are the prestigious National Institute of Neurological Disorders and Stroke (NINDS) Javits Neuroscience Investigator Award and the Inaugural American Heart Association (AHA) Outstanding Stroke Research Mentor Award. Dr. McCullough completed her PhD in Neuroscience and medical degree from the University of Connecticut. She continued her training at Johns Hopkins and was a resident in neurology from 1996-2000. Her residency was followed by a fellowship in cerebrovascular disease and stroke (2000-2002). After completing her training, she joined the faculty at Johns Hopkins Hospital and began her translational research career. She became an Instructor and then an Assistant Professor in Neurology at Hopkins. She was supported by the American Heart Association, first as a fellow, then as a faculty member by a career development award and by the Hopkins sponsored Passano fellowship. This support was instrumental to her academic success, and the infrastructure and mentorship she received allowed her to successfully compete for her first RO1 grant. Dr. McCullough relocated to Connecticut in 2004 and over the next eight years rose to the rank of Professor in the Departments of Neurology and Neuroscience at The University of Connecticut Health Center and at the John Dempsey Hospital in Farmington, Connecticut. She became the Director of Stroke Research and Education at Hartford Hospital, and developed one of the largest stroke centers in New England. In 2015, she relocated to the University of Texas Health Science Center in Houston 2015 as the Chair of Neurology and Chief of the Neurology service at Memorial Hermann Hospital. She brought 24 members of her laboratory and clinical program with her and over the past three years has developed the Neurology Department at UT Health into one of the top twenty NIH-funded Neurology Departments in the country.Tony Parkeris the program leader of the Tissue Repair and Translational Physiology (TRTP) Program at the Institute of Health and Biomedical Innovation (IHBI) at the Queensland University of Technology in Brisbane, Australia. He is also a Senior Lecturer within the School of Biomedical Sciences at QUT. Dr. Parker’s research has focused on the biochemical implications of musculoskeletal and skin tissue injury and recovery processes. In particular his team has utilized 2D and 3Din vitroskin wound models and developed the workflows required for the proteomic and metabolomic investigation of wound and tissue fluids. To achieve this he played a key role in the establishment of the world class proteomics and metabolomics capability at QUTs Central Analytical Research Facility (CARF). Dr. Parker’s team also has an interest in the health promoting effects of physical activity wherein his team found that moderate levels of exercise in healthy individuals induces the systemic release of the neuroprotective / neuroreparative protein known as the LG3 peptide. This finding may have implications for stroke prevention and rehabilitation and his team is currently exploring the effect of exercise on the release of circulating LG3 peptide in a small clinical cohort.Mary Pelleymounteris a Program Director in the Division of Translational Research at NINDS. She leads the new Biomarker Development Initiative at NINDS, and is a scientific project manager for the Blueprint Neurotherapeutics program. She has over 25 years of experience in scientific research and over 20 years of experience in drug discovery and development. Mary Ann’s scientific training is in the field of behavioral neuroscience with a focus on age-related cognitive dysfunction, neurodegeneration and neuropharmacology. She received her PhD at the University of Colorado and conducted her post-doctoral research at the University of North Carolina (Chapel Hill) in the laboratory of Dr. Michela Gallagher. Following her post-doctoral work, Dr. Pelleymounter focused her research on drug discovery and development in the therapeutic areas of neurodegeneration and neuropsychiatry until the mid-1990s when she shifted her research emphasis to obesity and metabolic disease therapeutics. Since that time, Dr. Pelleymounter moved to scientific leadership roles, directing in vivo pharmacology at Neurocrine Biosciences and leading the biology drug discovery effort for obesity therapeutics at Bristol Myers Squibb. During Dr. Pelleymounter’s tenure as Director of Obesity Therapeutics, her department progressed multiple compounds into clinical development and helped to restructure the focus of their drug discovery efforts to better complement the existing efforts in diabetes and metabolic disease. Dr. Pelleymounter has over 60 published original research articles, reviews and book chapters, is the author of multiple published patents relating to the discovery and use of leptin and has received numerous research grants and awards in the fields of cognition, aging and neuropsychiatry.Farida Sohrabji, Ph.D., FAHA, is the Joseph Shelton Professor of Neuroscience and Associate Department Head of Neuroscience and Experimental Therapeutics at the Texas A&M College of Medicine. Dr. Sohrabji obtained a joint doctoral degree in Neurobiology & Biopsychology from the University of Rochester (Rochester, NY) and completed her post-doctoral training at Columbia University, College of Physicians and Surgeons (New York, NY). Dr. Sohrabji joined the faculty of Texas A&M College of Medicine in 1998, where she is actively involved in the training of graduate and medical students and mentorship of junior faculty. She directs a federally-funded research program that focuses on sex and age differences in cerebrovascular disease, specifically, biochemical and behavioral changes following stroke-related injury, including brain-immune interactions, profiling epigenetic biomarkers and identifying novel therapies for ischemic stroke.  Dr. Sohrabji is the Founder and Director of the Women’s Health in Neuroscience Program at the Texas A&M College of Medicine, and a strong advocate for the inclusion of gender/sex differences in biomedical research. She is a past member of the NIH Advisory Council on Research on Women’s Health, and currently serves on NIH and AHA study sections, and the editorial boards of Frontiers in Neuroendocrinology and Neurochemistry International. In 2017, Dr. Sohrabji was selected as a member of the inaugural class of Texas A&M University Presidential Impact Fellows.John H. Zhang, MD, PhD, FAHA is a professor in Anesthesiology, Neurosurgery and Physiology in Loma Linda University, California. He achieved his MD from Chongqing Medical University China in 1983 and PhD in University of Alberta Canada in 1992. He has obtained 33 million USD grants from NIH, DoD, AHA and other foundations, edited 20 stroke or CNS disorder related book, edited 25 special journal issues on stroke, published by June 2017 728 articles, among them 369 originals, 130 supplements, 109 reviews, 63 editorials/letters, and 55 book chapters. ORCID recorded 696 papers, cited by 9,878 papers and cited of 17,236 times, H-index 69. He has given more than 200 invited speeches.

Center for Advanced Translational Stroke Science at the University of Kentucky

<IMG ALT="Spindletop in the fall" SRC="https://cdn.evbuc.com/eventlogos/221062055/spindletopfrontofhousefall.jpg">After a successful inaugural workshop, the second annual Stroke Translational Research Advancement Workshop (STRAW) will commence on October 24th, 2018. As with last year’s workshop, eminent clinical and basic stroke researchers will be presenting the most recent advancements in the area of translational research. Besides the presentations, this workshop offers a moderator-led open discussion airing the issues in this research area, and providing opportunities to share ideas and obtain expertise in stroke translational research development. There will be participant workgroups focusing on major issues in translational research, with the goal to draft publications for sharing findings and recommendations. Finally, the agenda provides ample opportunity to network with fellow national and international stroke researchers, with the goal to generate long-lasting collaborative relationships to propel the science and treatment of stroke into new innovation and development.  Based on feedback from last year, meeting attendance is being capped so please register early to ensure your spot is confirmed!   Please note that there are two options under the green "register" tab.  By selecting the first option, you will register for the workshop and if you want to participate in the optional excursion, you must also select that option.
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Spindletop Hall
                                                                    PRELIMINARY AGENDA
Day 1 – Oct 24th
 0800-0830       Registration, Continental Breakfast, and Welcome Remarks (Bix/Pennypacker)
 0830-0915       The year that was: Clinical and scientific advancements in translational stroke in 2018                                           (John Zhang)
 0915-1015       The Holy Grail? Revascularizing the ‘completed stroke’ and opening the door to neuro-reparative                           therapy (Sameer Ansari)
 1015-1030       Coffee Break
 1030-1130       Age and gender in translational stroke research- how to leverage our differences for more                                     impactful science (Farida Sohrabji)
 1130-1230       So you want to be a translational stroke scientist? Lessons from the newly converted. (Anthony                             Parker)
 1230-1345       Networking Lunch at Themed Tables
 1400                Board Buses for Afternoon Activities
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AFTERNOON DESTINATION ACTIVITY (optional)
More information can be found in the description under the "register" tab.
 1430-1645       Afternoon at the races!  Transport to Keeneland, a world class Thoroughbred horse racecourse. 
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1730-2100       Distillery tour/mixology class/dinner at Jeptha Creed, a unique craft distillery.                       
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 Day 2 – Oct 25th
 0800-0830      Continental Breakfast and Announcements
0830-0930       IGNITE:  Preclinical drug discovery to the clinic (Mary Ann Pelleymounter NIH/NINDS)
0930-1015       Building a House of Innovation: Developing a Robust Program for Stroke Translational Research                          as a Department Chair (Louise McCullough)
1015-1030       Coffee Break
 1030-1200      Interactive Brainstorming – Moderator-led group discussions around questions/data/ideas                                      presented by a handful of researchers (please indicate your interest in presenting at the                                  checkout prompt).
 1200-1315      Lunch seminar – How to translate science to therapy from Industry perspective
 1315-1600      Workgroups for paper publication
                          - Participants are invited to remain for the afternoon to help draft possible                                                                  publications from the Workshop.
                          - Groups will form around particular topics, discuss recommendations and                                                                  concrete methods for moving the field forward.
                          -Writing groups will be formed to continue the work after the meeting.
 The following subjects will be discussed in four workgroups:
                          -Aged Animals on a Budget...How?
                          -Stroke Clinical Trial Design-Failures vs. Successes (IMS III vs ELVO trials)
                          -Renaming Stroke Models for their Target Subtype
                          -Workflow for Field Diagnostic Point-of-Care Biomarker Development
 
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A limited hotel block with a promotional rate has been secured with Embassy Suites, Lexington/UK Coldstream at 1801 Newtown Pike.  It is important to confirm early as there are competing events in town!  Embassy Suites provides a daily complimentary cooked breakfast, a complimentary manager’s reception each evening with drinks and snacks, and free wifi.
Booking Link:  <A HREF="https://na01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fsecure3.hilton.com%2Fen_US%2Fes%2Freservation%2Fbook.htm%3FinputModule%3DHOTEL%26ctyhocn%3DLEXESES%26spec_plan%3DCESRAW%26arrival%3D20181023%26departure%3D20181025%26cid%3DOM%2CWW%2CHILTONLINK%2CEN%2CDirectLink%26fromId%3DHILTONLINKDIRECT&data=02%7C01%7Ccindy.cusack%40uky.edu%7C89c37b09574d4ae2e41408d594beb68f%7C2b30530b69b64457b818481cb53d42ae%7C0%7C0%7C636578469184667545&sdata=amf3mhp4BAdfvFSFwaRj8gFClKrf2llfEO9R2ErvTZ0%3D&reserved=0" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">STRAW</A>
Hotel: Embassy Suites, Lexington/UK Coldstream
Group Name: STRAW
Dates: Arrival 23 October, 2018, Departure 25 October, 2018
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Transportation - complimentary shuttles will run both mornings from the Embassy Suites to Spindletop Hall (meeting venue).  For those participating in the afternoon destination activity on October 24th, transportation is provided from Spindletop to both points of interest and returning to Spindletop and the Embassy Suites that evening.  Transportation will be on your own for those not participating in the optional activity on the 24th to return to the hotel.  Transportation after the meeting on the 25th is on your own.  Lexington has cab, lyft and uber services.
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STRAW 2018 - Stroke Translational Research Advancement Workshop

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STRAW 2018 - Stroke Translational Research Advancement Workshop

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