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Francis Crick Institute

1 Midland Road

London

NW1 1ST

United Kingdom

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RET Research Collaborative Network inaugural meeting. Exchange ideas and collaborate to facilitate innovation in research and clinical care. RET gene mutations are responsible for a range of rare diseases including multiple endocrine neoplasia II, famillial and sporadic medullary thyroid cancer and phaeochromocytomas, Hirschsprung's disease, congenital kidney and urinary tract abnormalities and intellectual disabilities. A free event for health professionals and researchers supported by the Francis Crick Institute and the Society for Endocrinology.

PROGRAMME

08:00-09:00 Registration and refreshments

09:00-09:10 Welcome (Tom Kurzawinski and Rakhee Chauhan)

​Session 1: An Introduction to RET and MEN2 (Chairs: Professor Rajesh Thakker, Mrs Jo Grey)

09:10-09:35 A RETrospective view of GDNF signalling (Professor Neil McDonald, Senior Group Leader, Francis Crick Institute)

09:35-10:00 Testing for RET: indications, results, VUS (Dr Louise Izatt, Consultant in Clinical Genetics, Guy's and St Thomas's NHS Foundation Trust and King's College London)

10:00-10:25 Thyroid Surgery in MEN2: A Gospel according to RET? (Mr Tom Kurzawinski, Consultant Endocrine Surgeon, UCLH and GOSH)

10:25-10:50 RET and Oncogenesis with a focus on MEN2 Syndrome (Dr Rakhee Chauhan, Postdoctoral Research Fellow, Francis Crick Institute)

10:50-10:55 Session Discussion

10:55-11:15 Networking Refreshment Break

Session 2: RET and Hirschsprung’s Disease (Chairs: Dr Nikhil Thapar, tbc)

11:15-11:40 Sex differences in the roles of RET iso forms in the enteric nervous system and brain (Robin Lovel-Badge / Rosalyn Flowers, Senior Group Leader / PhD Student, Francis Crick Institute)

11:40-12:05 Identification, treatment and genetics of Hirschsprung's Disease (Dr Robert M W Hofstra, Head of Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands)

12:05-12:30 Structural insights into RET folding (Dr Svend Kjaer, STP Deputy, Francis Crick Institute)

12:30-12:40 Session Discussion

12:40-13:30 Lunchtime Networking

Session 3: Diverse Roles of RET (Chairs: Professor Marta Korbonits, Dr Caroline Brain)

13:30-13:55 The Pituitary and RET (Professor Clara Alvarez, Santiago de Compostela, Spain)

13:55-14:20 Parkin regulates RET protein levels (Dr Edgar Kramer, Group Leader, University of Plymouth)

14:20-14:45 Novel functions in RET signalling: RET and GFRAL in body weight regulation (Dr Sebastian Jorgensen, Novo Nordisk)

14:45-15:10 Activation of RET signalling improves haematopoietic stem cell potency and bone marrow transplantation (Dr William Grey, Postdoctoral Research Fellow, Francis Crick Institute)

15:10-15:35 Session Discussion

15:35-15:55 Networking Refreshment Break

Session 4: Targeting RET in Oncology (Chairs: Dr Rakhee Chauhan, Professor Ashley Grossman)

15:55-16:20 TracerX RET fusions in NSCLC (Dr Crispin Hiley, Senior Lecturer & Consultant Clinical Oncologist, UCLH)

16:20-16:45 Therapy of human cancers with RET fusion: from multiple kinase inhibitors to specific inhibitors (Dr Takashi Kohno, Chief of the Devision of Genome Biology, National Cancer Centre Research Institute, Japan)

16:45-17:10 Targeting RET clinically: past and present therapeutics (Dr Kate Newbold, Consultant Clinical Oncologist, The Royal Marsden Hospital, London)

17:10-17:35 Next generation RET inhibitors: the future is here! Blueprint BLU-667 clinical efficacy in lung cancer and medullary thyroid cancer (Dr Martin Forster, Associate Professor and Consultant in Medical Oncology, UCL Cancer Institute / UCLH)

17:35-17:45 Session Discussion

17:45-17:50 Closing Remarks



The event will be followed by a networking drinks reception at the Norfolk Arms

CPD Accreditation with the Royal College of Physicians applied for

[The programme may be subject to change without notice]


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Francis Crick Institute

1 Midland Road

London

NW1 1ST

United Kingdom

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