RET@CRICK

A collaboration of researchers, clinicians and other stakeholders with an interest in the RET gene

RET Research Collaborative Network

RET Research Collaborative Network inaugural meeting.  Exchange ideas and collaborate to facilitate innovation in research and clinical care.  RET gene mutations are responsible for a range of rare diseases including multiple endocrine neoplasia II, famillial and sporadic medullary thyroid cancer and phaeochromocytomas, Hirschsprung's disease, congenital kidney and urinary tract abnormalities and intellectual disabilities.  A free event for health professionals and researchers supported by the Francis Crick Institute and the Society for Endocrinology.
PROGRAMME
08:00-09:00 Registration and refreshments
09:00-09:10 Welcome (Tom Kurzawinski and Rakhee Chauhan)
​Session 1: An Introduction to RET and MEN2 (Chairs: <A HREF="https://royalsociety.org/people/rajesh-thakker-12590/" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Professor Rajesh Thakker</A>, <A HREF="https://www.amend.org.uk/" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Mrs Jo Grey</A>)
09:10-09:35  A RETrospective view of GDNF signalling (<A HREF="https://www.crick.ac.uk/research/labs/neil-mcdonald" TARGET="_self" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Professor Neil McDonald, Senior Group Leader, Francis Crick Institute</A>)
09:35-10:00  Testing for RET: indications, results, VUS (<A HREF="https://www.guysandstthomas.nhs.uk/our-services/consultant-profiles/genetics/louise-izatt.aspx" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Dr Louise Izatt, Consultant in Clinical Genetics, Guy's and St Thomas's NHS Foundation Trust and King's College London</A>)
10:00-10:25  Thyroid Surgery in MEN2: A Gospel according to RET? (<A HREF="https://www.uclh.nhs.uk/OurServices/Consultants/Pages/MrTomRKurzawinski.aspx" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Mr Tom Kurzawinski, Consultant Endocrine Surgeon, UCLH and GOSH</A>)
10:25-10:50  RET and Oncogenesis with a focus on MEN2 Syndrome (Dr Rakhee Chauhan, Postdoctoral Research Fellow, Francis Crick Institute)
10:50-10:55  Session Discussion
10:55-11:15  Networking Refreshment Break
Session 2: RET and Hirschsprung’s Disease (Chairs: <A HREF="https://www.gosh.nhs.uk/our-people/staff-z/nikhil-thapar" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Dr Nikhil Thapar</A>, tbc)
11:15-11:40  Sex differences in the roles of RET iso forms in the enteric nervous system and brain (Dr <A HREF="https://www.crick.ac.uk/research/find-a-researcher/robin-lovell-badge" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Robin Lovell-Badge</A> / Dr <A HREF="https://www.crick.ac.uk/research/find-a-researcher/rosalyn-flower" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Rosalyn Flower</A>, Senior Group Leader / Research Assistant, <A HREF="https://www.crick.ac.uk/research/labs/robin-lovell-badge" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Francis Crick Institute</A>)
11:40-12:05  Identification, treatment and genetics of Hirschsprung's Disease (<A HREF="https://www6.erasmusmc.nl/klinische_genetica/research/introduction/hofstra/?lang=en" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Dr Robert M W Hofstra, Head of Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands</A>)
12:05-12:30  Structural insights into RET folding (<A HREF="https://www.crick.ac.uk/research/platforms-and-facilities/structural-biology" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Dr Svend Kjaer, STP Deputy, Francis Crick Institute</A>)
12:30-12:40  Session Discussion
12:40-13:30  Lunchtime Networking
Session 3: Diverse Roles of RET (Chairs: <A HREF="https://www.qmul.ac.uk/whri/people/academic-staff/items/korbonitsmarta.html" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Professor Marta Korbonits</A>, <A HREF="https://www.gosh.nhs.uk/medical-information/staff-z/caroline-brain" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Dr Caroline Brain</A>)
13:30-13:55  The Pituitary and RET (<A HREF="https://www.researchgate.net/profile/Clara_Alvarez" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Professor Clara Alvarez, Santiago de Compostela, Spain</A>)
13:55-14:20  Parkin regulates RET protein levels (<A HREF="https://www.plymouth.ac.uk/research/parkinsons" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Dr Edgar Kramer, Group Leader, University of Plymouth</A>)
14:20-14:45  Novel functions in RET signalling: RET and GFRAL in body weight regulation (<A HREF="https://www.researchgate.net/profile/Sebastian_Jorgensen" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Dr Sebastian Jorgensen, Novo Nordisk</A>)
14:45-15:10  Activation of RET signalling improves haematopoietic stem cell potency and bone marrow transplantation (<A HREF="https://www.crick.ac.uk/research/labs/dominique-bonnet" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Dr William Grey, Postdoctoral Research Fellow, Francis Crick Institute</A>)
15:10-15:35  Session Discussion
15:35-15:55  Networking Refreshment Break
Session 4: Targeting RET in Oncology (Chairs: <A HREF="https://pharmcollege.uams.edu/aboutus/contact-us/directory/faculty-member-hong-yu-li/" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Professor Hong-yu Li</A>, <A HREF="https://www.royalfree.nhs.uk/services/staff-a-z/prof.-ashley-grossman/" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Professor Ashley Grossman</A>)
15:55-16:20  TracerX RET fusions in NSCLC (<A HREF="https://www.researchgate.net/profile/Crispin_Hiley" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Dr Crispin Hiley, Senior Lecturer & Consultant Clinical Oncologist, UCLH</A>)
16:20-16:45  Therapy of human cancers with RET fusion: from multiple kinase inhibitors to specific inhibitors (<A HREF="http://tlcr.amegroups.com/user/view/42188" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Dr Takashi Kohno, Chief of the Devision of Genome Biology, National Cancer Centre Research Institute, Japan</A>)
16:45-17:10  Targeting RET clinically: past and present therapeutics (<A HREF="https://www.royalmarsden.nhs.uk/our-consultants-units-and-wards/consultant-directory/dr-kate-newbold" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Dr Kate Newbold, Consultant Clinical Oncologist, The Royal Marsden Hospital, London</A>)
17:10-17:35  Next generation RET inhibitors: the future is here! Blueprint BLU-667 clinical efficacy in lung cancer and medullary thyroid cancer (<A HREF="https://www.uclh.nhs.uk/OurServices/Consultants/Pages/DrMartinForster.aspx" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Dr Martin Forster, Associate Professor and Consultant in Medical Oncology, UCL Cancer Institute / UCLH</A>)
17:35-17:45  Session Discussion
17:45-17:50  Closing Remarks
<HR>
 
The event will be followed by a networking drinks reception at the <A HREF="https://norfolkarms.co.uk/" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Norfolk Arms</A>
CPD Accreditation with the Royal College of Physicians applied for
[The programme may be subject to change without notice]

Francis Crick Institute

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