Human Sleep Genetics

The Simons Foundation’s mission is to advance the frontiers of research in mathematics and the basic sciences.

Simons Foundation

Registration for this lecture will close at 2 p.m. the day of the event. Review the complete list of entrance requirements below.

Gerald D. Fischbach Auditorium

<h2>This lecture is part of The Neuroscience of Sleep Presidential Lecture Series in Neuroscience and Autism Science.</h2>

Sleep is critical for health, and chronic sleep disruption increases the risk of virtually every disease. In 2012, modern human genetics was applied to understanding the genetics and biology of human sleep regulation for the first time. That year, Louis Ptáček, Ying-Hui Fu and their colleagues identified and characterized the first families with heritable normal circadian traits.In this Presidential Lecture, Ptáček will discuss his research into the role of genetics in human sleep. He will discuss how he and Fu studied familial advanced sleep phase (FASP), a trait that manifests as a lifelong tendency to go to sleep and wake up unusually early (with wake-up times around 1–4 a.m.). Ptáček and Fu went on to characterize mutations in a growing list of genes that underlie the phenotype in around 15 percent of FASP families and to study them in vivo in mouse models. In vitro and in vivo experiments focused on regions harboring human mutations have led to novel insights in fine-tuning circadian period regulation by phosphorylation. More recently, with Fu’s identification of the first families with familial natural short sleep (FNSS), they’ve set out to identify a growing list of genes regulating sleep homeostasis and efficiency. As they begin to understand the biology underlying sleep, new opportunities are being presented to improve human health by targeting sleep quality as a target to reduce the risk of many diseases.<a href="https://profiles.ucsf.edu/louis.ptacek" target="_blank" data-msys-clicktrack="0" rel="nofollow noopener noreferrer">Ptáček</a> uses human genetics tools to study patients with an impressive range of human phenotypes. He pioneered the field of ‘channelopathies,’ which encompasses a large group of episodic/electrical disorders of muscle, heart and brain. More recently, he has entered the challenging field of behavioral genetics and established the field of human sleep genetics. He and his colleagues use genetics to help us understand what sleep is and why we need it. He is a member of the National Academy of Medicine, the American Association of Arts and Sciences and the National Academy of Science.

REGISTRATION REQUIREMENTS<ul><li>You must be 18+ to attend this event</li><li>Registration will close at 2:00 p.m. the day of the event</li><li>Please only register yourself and use your complete first and last name as it appears on your photo ID when filling in the form.</li><li>If you have a guest you would like to bring with you to this event, please send them the link to register so they can sign up on their own.</li></ul>BUILDING ENTRY PROTOCOL<ul><li>Provide valid photo ID</li><li>Present your digital or printed Eventbrite ticket confirmation; make sure it is for the correct event and that the name on it matches your ID.</li><li>Limited seating is available for this in-person event and is on a first-come, first-served basis.</li><li>All attendees must be pre-registered. Walk-in entry will be denied.</li></ul>Please note that by entering the Simons Foundation, you are attesting that you are not experiencing COVID symptoms and are not knowingly positive for COVID.SCHEDULEDoors open: 5:30 p.m. (No entrance before 5:30 p.m.)Lecture: 6:00 – 7:00 p.m. (Admittance closes at 6:20 p.m.)The Gerald D. Fischbach Auditorium complies with the Americans with Disabilities Act and offers accessible seating to visitors with special access needs.

<a href="https://www.simonsfoundation.org/sf-events/?type=simons-foundation-presidential-lectures&amp;swcfpc=1" target="_blank" data-msys-clicktrack="0" rel="nofollow noopener noreferrer">Presidential Lectures</a> are free public colloquia centered on four main themes: Biology, Physics, Mathematics and Computer Science, and Neuroscience and Autism Science. These curated, high-level scientific talks feature leading scientists and mathematicians and are intended to foster discourse and drive discovery among the broader NYC-area research community. We invite those interested in the topic to join us for this weekly lecture series.

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Human Sleep Genetics

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Human Sleep Genetics

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