Human sample authentication in biomedical research using molecular sample..

ESBB's mission is to advance biosharing for a better world through mobilising, inspiring, and educating the biobank community across Europe, the Middle East, Africa, and beyond.  ESBB (www.esbb.org) is a society of individual members, academic institutions, corporate members and sponsors. Through annual conferences, strategic committees, working groups and other activities, ESBB provides a wide interdisciplinary platform for dissemination of knowledge, education, policy making as well as science and innovation projects. Together with our members, stakeholders and sponsors we address todaysand tomorrows biobanking challenges and biobanking opportunities for a healtier world.

ESBB - European, Middle Eastern & African Society for Biopreservation and Biobanking

Human sample authentication in biomedical research using molecular sample identification: comparison of two platforms with Sara Tomei

Fluidigm brief Introduction:

Fluidigm is committed to empowering laboratories to efficiently scale genomic workflows and meet the increasing demands of molecular testing and biobanking. Using the industry proven Advanta™ Sample ID Genotyping Panel, we provide an automated, cost-effective and easy-to-use DNA fingerprinting (molecular sample identification) workflow that allows for simultaneous sample identification and QC in biorepositories worldwide, drastically reducing the number of incorrectly labeled or poor quality samples making it to analysis or redistribution
Abstract:Samples used in biomedical research are often collected over years, in some cases from subjects that may have died and thus cannot be retrieved in any way. The value of these samples is priceless. Sample misidentification or mix-up are unfortunately common problems in biomedical research and can eventually result in the publication of incorrect data. Here we have compared the Fluidigm SNPtrace and the Agena iPLEX Sample ID panels for the authentication of human genomic DNA samples. We have tested 14 pure samples and simulated their cross-contamination at different percentages (2%, 5%, 10%, 25% and 50%). For both panels, we report call rate, allele intensity/probability score, performance in distinguishing pure samples and contaminated samples at different percentages, and sex typing. We show that both panels are reliable and efficient methods for sample authentication and we highlight their advantages and disadvantages. We believe that the data provided here is useful for sample authentication especially in biorepositories and core facility settings.

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Human sample authentication in biomedical research using molecular sample..

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Human sample authentication in biomedical research using molecular sample..

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