FACTOR 2024

MIB Agents

Collaboration with all interested parties on advancing treatments and improving outcomes for patients with osteosarcoma.

Hotel Cleveland

FACTORFunding *Awareness * Collaboration * Trials * Osteosarcoma ResearchBeginning in 2017, MIB Agents annual FACTOR Osteosarcoma Conference brings together the leading researchers, clinicians, &amp; patient families annually with the goal of improving osteosarcoma treatments and causing a cure.At FACTOR, we:• Improve osteosarcoma awareness and patient outcomes through a collaborative disease management approach, clinical trials, and dedicated osteosarcoma research.• Brainstorm on challenges and develop collaborative solutions to fast track improvements for osteosarcoma.• Create a synergistic bridge between the osteosarcoma medical and patient community to overcome challenges and create solutions.• Evaluate funding needs for research and provide awareness for worthy initiatives and funding solutions.• Review progress on an annual basis on various osteosarcoma disease management initiatives.OsteoWarriors HQThe OsteoWarriors HQ (Headquarters) brings kids and young adults who have a connection to osteosarcoma together and It. Is. Awesome! HQ activities are designed for kids/young adults aged 8 - 22. We kindly ask that only those who plan to fully participate in HQ select the HQ registration option. OsteoWarrior HQ is for:• Warriors in treatment for osteosarcoma• Survivors of osteosarcoma• Siblings of OsteoWarriors• Siblings of OsteoAngelsConnecting the kids who have lost limbs, friends and siblings to osteosarcoma is one of the most important things we do. To put the hospital behind them for a few days and connect with other kids from across the country who have been through the same thing they have is really special.The OsteoWarriors HQ is entirely complimentary, with thanks to the generosity of the Zimmerman Foundation.NEW: Prom Night!We are pleased to announce this year’s FACTOR conference will include an Enchanted Forest-themed prom hosted after dinner on Friday, June 21st.Dance the Night Away at FACTOR Enchanted Forest Prom! Bring your best dance moves and get ready for a night you won’t forget!Prom attire is encouraged.If interested in table, please contact Anita at anita@mibagents.orgFactor Registration PurchasesPlease note, all passes are non-refundable upon purchase.

FACTOR Scientific Panel PreviewTune into our OSBItes episode with Matteo Trucco, MD, pediatric oncologist, Director of the Children’s Cancer Innovative Therapy program at the Cleveland Clinic, and chair of the MIB Agents Scientific Advisory Board who provides a brief overview of vocabulary and scientific terms.

Thursday, June 20th

Open to MIB Agents Ambassador Agents. Ambassador Agents offer peer support to caregivers and families in treatment for osteosarcoma. Ambassador Agents are:

Survivors and caregivers in the osteosarcoma community
Out of treatment for at least one year
Comfortable with your own journey to support someone in the midst of theirs
Want to Make It Better by showing up to offer support
The Ambassador Agent training will prepare you in best practices to support a warrior and/or their family members. Listening skills, ways to build trust, stages of grief and recovery, stress management and the ever popular 'elevator speech' are the foundation of the training. Being an Ambassador Agent is a rewarding experience for both you and the family you are matched with.

MIB Agents Ambassador Agents Training

Open to MIB Family Funds,  parents and adult siblings ages 22+

MIB Agents Family Funds & New Families Welcome Reception

FACTOR 2024 Welcome Reception. Open to all registered attendees. Highlights include the annual Docs vs. Warriors game where each team battles it out for the coveted Golden Bone.

FACTOR 2024 Welcome Reception

Hosted dinner for FACTOR 2024 moderators and panelists.

Speaker Dinner

General Attendees and MIB staff will head to restaurant with special MIB menu pricing.

Non-Hosted Dinner

Friday, June 21st

Morning Gentle Breathwork & Meditation 

Hosted breakfast open to all registered attendees.

Breakfast

The MIB Agents team will provide an overview of events and fundraisers, patient programs, and scientific programs.

MIB Agents Welcome and Overview

HOW AI WILL IMPACT CLINICAL PRACTICE AND RESEARCH
Moderator: Satish E. Viswanath, PhD, Case Western University | Panelists: 


Christa LiBrizzi, MD | Johns Hopkins Hospital | The Use of Weakly-Supervised Deep Learning for Necrosis Assessment in Patients with Osteosarcoma


Eric Stahlberg, PhD | Frederick National Laboratory for Cancer Research | Envisioning Digital Twins for Cancer


Rong Xu, PhD | Case Western Reserve University | Knowledge-driven Artificial Intelligence for Drug Discovery

Satish E. Viswanath, PhD | Case Western Reserve University | Pixels to Predictions: Developing Imaging AI for Precision Oncology

Panel:  How AI Will Impact Clinical Practice and Research

How to Speak to Bereaved Families

Yoga Nidra

Break

PRECLINICAL MODELS
Moderator: Filemon Dela Cruz, MD, Memorial Sloan Kettering Cancer Center | Panelists:


Fiona Freeman, PhD | University College Dublin | Engineering Complex Models of Osteosarcoma: Unravelling Tumour Microenvironment Interactions for Drug Discovery and Therapeutic Innovation


Kent Leach, PhD | UC Davis Health |  Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening 


Josh Nash, BSc.H | The Hospital for Sick Children | Validating preclinical models of osteosarcoma using multiscale transcriptomics


Ram Rao, MD, PhD | Stanford University | 3D Collagen Culture Induces Osteosarcoma Chemoresistance through Drug Efflux Pump Overexpression


Alice Soragni, PhD | UCLA | Patient-derived organoid models of osteosarcoma


Xin Zhou, PhD | MD Anderson Cancer Center | Genomic Profiling and Modeling of Osteosarcoma Development in Murine Chondrocyte-Origin Models


Panel: Preclinical Models

An annual tradition - make sure you are included in the group photo of all FACTOR 2024 registered attendees! 

Group Photo

Hosted lunch open to all registered attendees.

Lunch

TARGETING METASTASIS DRIVERS
Moderator: Richard Gorlick, MD, MD Anderson Cancer Center | Panelists:


Heather Gardner, DVM, PhD | Tufts University | Leveraging liquid biopsy for early detection of treatment resistance and metastasis


Amy LeBlanc, DVM | NIH/NCI - Comparative Oncology Program | Determinants of metastatic progression in canine osteosarcoma - a translational patient animal model for humans


James Morrow, MD, PhD | Dana-Farber Cancer Institute |  Enhancer Rewiring Drives Osteosarcoma Metastasis 


Ryan D. Roberts, MD, PhD | Nationwide Children's Hospital | Combination therapies targeting heterogeneity and lung environment in metastatic osteosarcoma


Marta Roman Moreno, PhD | University of California San Francisco | CRISPRi screening to identify vulnerabilities in metastatic osteosarcoma

Panel: Targeting Metastasis Drivers

Flower Arranging 1

Crocheting 

All About Bunnies

OVERCOMING DRUG RESISTANCE
Moderator: John Healey, MD, Memorial Sloan Kettering Cancer Center | Panelists:


Isidro Cortés-Ciriano, PhD | EMBL-EBI | Mechanisms underpinning osteosarcoma genome complexity and evolution


Lucia Cottone, PhD | University College London, Cancer Institute | Overcoming osteosarcoma chemoresistance by understanding and targeting cellular quiescence


Sylvester Jusu, PhD | MD Anderson Cancer Center | Methotrexate resistance reveal diversity in clonal architecture and drug uptake in barcoded Osteosarcoma PDX Models


Gabriel Mandel, MD | Cleveland Clinic | Collateral Sensitivity During the Evolution of Resistance in Osteosarcoma Cells


Fariba Navid, MD | USC/Children's Hospital Los Angeles | Identification of Circulating Immune Cell Signature as a Biomarker of Disease Response and Resistance in Patients with Relapsed Osteosarcoma Treated with Nivolumab and Regorafenib

Panel: Overcoming Drug Resistance

Sound Bath 1

Break Through Cancer Osteosarcoma Project

OutSmarting Osteosarcoma 2024 Awards

Hosted dinner open to all registered attendees.

Dinner

Dance the Night Away at FACTOR Enchanted Forest Prom! Bring your best dance moves and get ready for a night you won’t forget! Prom attire is encouraged. Open to all registered attendees. Prom only tickets are also available for those who are not registered for the FACTOR conference. 

Enchanted Forest Prom

Saturday, June 22nd

Morning Run with Matteo Trucco, MD

KEY PATHWAYS FOR OSTEOSARCOMA TREATMENT
Moderator: Katie Janeway, MD, Dana-Farber Cancer Institute | Panelists:


Rani George, MD, PhD | Dana-Farber Cancer Institute | MYC overexpression in osteosarcoma


Lillian (Lily) Guenther, MD | St. Jude Children's Research Hospital | Optimizing DNA damage repair pathway inhibition for osteosarcoma therapy


Amanda Marinoff, MD | University of California San Francisco | Advancing precision oncology in osteosarcoma: Novel biomarkers for enhanced risk stratification and tailored treatment strategies


Doug Thamm, VMD | Colorado State University | Pharmacokinetics, Pharmacodynamics and Tolerability of Vismodegib in Dogs with Spontaneous Osteosarcoma


Betsy Young, MD | UCSF Benioff Children's Hospital | Tumor cGAS-STING repression drives immune evasion in osteosarcoma and is therapeutically targetable via host STING activation

Panel: Key Pathways for Osteosarcoma Treatment

CREATING AN OSTEOSARCOMA ATLAS (CONCURRENT WITH LOCAL CONTROL PANEL) 
Moderator: Jovana Pavisic, MD | Columbia University Irving Medical Center 
Panelists:
Ching Lau, MD, PhD | Connecticut Children's Medical Center | Immunosuppressive tumor microenvironment in osteosarcoma


Antonin Marchais, PhD, HDR | Gustave Roussy | Osteosarcoma stratification and subtyping with multi omics approaches


Troy McEachron, PhD | National Cancer Institute | Doing a lot from a little: Multi-omic profiling of metastatic osteosarcoma


Corey Weistuch, PhD | Memorial Sloan Kettering Cancer Center | Mapping the single-cell differentiation landscape of osteosarcoma


Mo Yang, PhD | UT Southwestern Medical Center | Osteosarcoma Explorer, a data commons with clinical, genomic, protein, and tissue imaging data for osteosarcoma research

Panel: Creating an Osteosarcoma Atlas

LOCAL CONTROL (CONCURRENT WITH CREATING AN OSTEOSARCOMA ATLAS PANEL)
Moderator: Nathan Mesko, MD, Cleveland Clinic | Panelists:


Andrew Frankart, MD | Cincinnati Children's Hospital Medical Center/University of Cincinnati | Flash Radiotherapy: Current Work and Future Directions


Jenna Kocsis, MD | Cleveland Clinic | Multi-Site SBRT for Pediatric, Adolescent, and Young Adult Patients with Osteosarcoma: Local Failure Dosimetric Analysis


Tom Scharschmidt, MD | Nationwide Children's Hospital | 3D Virtual Planning and Patient-Specific Instrumentation to Improve Outcomes of Physeal-Sparing Intercalary Resections and Allograft Reconstructions


Raja Shaikh, MD | Boston Children's Hospital | Interventional radiology local control options in osteosarcoma


TJ Utset-Ward, MD, MBA | Nationwide Children's Hospital  | Separate Resection of Biopsy Tract and Primary Sarcoma: Implications for Local Recurrence and Overall Survival

Panel: Local Control

Let's Write OsteoWarrior Mail!

Moderator:  Andy Livingston, MD, MS, MD Anderson Cancer Center
MIB Agents Junior Advisory Board


Patient Panel

IMMUNOTHERAPY APPROACHES
Moderator: Alex Y. Huang, MD, PhD, UH Rainbow Babies & Children / Case Western Reserve University School of Medicine | Panelists:


Michelle Choe, MD | Fred Hutch Cancer Center | Preclinical evaluation of folate receptor alpha-specific CAR T cells against osteosarcoma


Eugenie S. Kleinerman, MD | MD Anderson Cancer Center | A novel dendritic cell vaccine targeting CD70 for osteosarcoma lung metastasis


Brian Mooney, PhD | BC Cancer Research Center | Harnessing the osteosarcoma surfaceome for immunotherapy targets to block metastatic capacity


Jacquline Oliva Ramirez, PhD | MD Anderson Cancer Center | Immune profile and functional evaluation of tumor-infiltrating lymphocytes in OS tumor microenvironment


Seth Pollack, MD | Northwestern University Lurie Cancer Center | Making Cellular Therapy Work for Osteosarcoma

Panel: Immunotherapy Approaches

Diamond Painting Class

Flower Arranging 2

Making a Wellness Plan

Sound Bath 2

CLINICAL TRIALS
Moderator: Jessica L. Davis, MD, Indiana University | Panelists:

Katie Albert, MD | Seattle Children's Hospital, U of Washington | CAR T Cell Immunotherapy for Osteosarcoma

Vishu Avutu, MD | Memorial Sloan Kettering Cancer Center | Phase 1 results of azenosertib plus gemcitabine in patients with relapsed or refractory osteosarcoma

Michael W. Bishop, MD MS | St. Jude Children's Research Hospital | Incorporating Multi-Targeted Tyrosine Kinase Inhibitors into Upfront Therapy for Osteosarcoma

Kat Bouzein, MS | University of Chicago | Data commons to support new treatments for osteosarcoma

Eirian Siegal-Botti | Count Me In at the Broad Institute of MIT and Harvard | The Osteosarcoma Count Me In Project of the Participant Engagement Cancer Genomic Sequencing Network: Directly Engaging Patients in Genomic Research

Lu Xie, MD, PhD | Peking University People's Hospital | Phase 1 Study of HS-20093, a B7-H3 Targeting Antibody-Drug Conjugate (ADC) in Relapsed or Refractory

Panel:  Clinical Trials

Closing Remarks

Sunday, June 23rd

Join us for a free Healing Hearts grief retreat for bereaved osteosarcoma parents.
This is an opportunity for you to connect with others who share a similar grief experience and understand what you're going through. The hope is that this event provides encouragement, support, and inspiration through planned activities and conversation. 
‍

Bereavement Session- Healing Hearts

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FACTOR 2024

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