Explore MeRGE: the Metrum Research Group Ecosystem

MetrumRG will be hosting a one-day hands-on workshop before the PAGE Congress on Tuesday, June 25 on MeRGE (the Metrum Research Group Ecosystem). MeRGE is a suite of freely-available, open-source tools for traceable, reproducible, and scalable pharmacometric workflows.

MetrumRG’s R package ecosystem includes:

• Metrum Package Network (MPN)/pkgr: curated R package environment
• bbi/bbr: user-friendly interface for R and NONMEM®
• bbr.bayes: Bayesian modeling extension with Stan and NONMEM®
• yspec: data specifications, wrangling, documentation
• pmplots: exploratory and diagnostic plots
• pmforest: forest plots for pharmacometrics
• mrggsave: labeling, arranging, saving figures
• pmtables: tables for pharmacometrics
• lastdose: calculate last dose amount, time since previous doses

Objectives

• Introduction to the individual MeRGE tools and packages and how they interconnect
• Demonstration of package use for scalability and reproducibility in project set-up, data assembly, data exploration, model development & evaluation, simulation, and reporting
• Hands on exercises to allow participants to gain experience in the MeRGE commands and navigating an example population PK workflow
• Identification of resources for additional learning

Requirements for Attendees

• Knowledge and experience in PK modeling and the use of R
• Laptop with Chrome or Safari browser