Evidence Integration Workshop

Board on Environmental Studies and Toxicology

<H2>Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions</H2>
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<H2> </H2>
WORKSHOP: JUNE 3-4, 2019, Washington, DC
The National Academies of Sciences, Engineering, and Medicine will be holding a workshop on JUNE 3-4, 2019, in Washington, DC, on evidence integration, which is a summary step of the systematic review in human health assessments conducted by the US Environmental Protection Agency (EPA). Topic areas include:  
<UL>
<LI>Lessons Learned from Recent International Workshops on Evidence integration in Risk Assessment,</LI>
<LI>Best Practices in Evidence Integration,</LI>
<LI>Approaches for Using Mechanistic Data to Integrate Evidence from Animal and Human Studies: General Considerations,</LI>
<LI>Systematic Review-Enabled Evidence Integration: Case Studies, and</LI>
<LI>Practical Approaches to Expedited Evidence Integration.</LI>
</UL>
Evidence integration, also referred to as weight-of-evidence evaluation, is a summary step of the systematic review in human health assessments conducted by EPA’s National Center for Environmental Assessment. During this step, conclusions are drawn from each line of evidence that is relevant to the predefined PECO criteria. (PECO refers to population, exposure, comparators, and outcomes.) Evidence integration generally involves subjecting the relevant evidence to a causal analysis, which can be conducted using both qualitative and quantitative approaches. This is a structured process by which conclusions are drawn regarding the potential health effects in exposed humans, incorporating judgments about the strength of the human and animal evidence (both within and across lines of evidence) as well as information from mechanistic data necessary to answer key questions.
The overall objective of the workshop is to explore strategies for addressing challenges that arise for EPA during evidence integration in chemical assessments, with a primary focus on the use of mechanistic data. Poster sessions will accompany the workshop to address topics that are relevant to the workshop session topics. 
The agenda has been finalized. <A HREF="https://cdn.evbuc.com/eventlogos/242568757/agendaevintegwksh52219.pdf" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Download it here</A>!
<A HREF="http://sgiz.mobi/s3/IWS-Evi-Int-Poster" TARGET="_blank" TITLE="Evidence Integration Workshop Poster Application" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer"></A> Project <A HREF="https://www8.nationalacademies.org/pa/projectview.aspx?key=51377" TARGET="_blank" DATA-MSYS-CLICKTRACK="0" REL="nofollow noopener noreferrer">Information</A>

National Academies of Sciences (NAS) Building

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Evidence Integration Workshop

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Evidence Integration Workshop

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