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Interactions of Tramadol: Tramadol can interact with other medications, particularly those that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and certain antidepressants. Combining tramadol with these drugs can increase the risk of serotonin syndrome, a potentially life-threatening condition.
Cautionary Notes: Tramadol should be used cautiously in certain populations, including individuals with a history of substance abuse, respiratory disorders, head injuries, seizures, or liver or kidney impairment. It is not recommended for use in children under the age of 12.
Withdrawal: Abrupt discontinuation of tramadol after prolonged use can lead to withdrawal symptoms, such as anxiety, agitation, sweating, insomnia, tremors, and gastrointestinal distress. Tapering off the medication under medical supervision is typically recommended to minimize withdrawal symptoms.
As with any medication, tramadol should be used under the guidance of a healthcare professional, and patients should be informed about its potential benefits, risks, and proper usage.