A dive into the cell – New opportunities for treatment of dementia

The Laboratory of Adaptive Immunity and Homeostasis

We welcome you to a seminar where we will dive into the cell and discuss new opportunities for treatment of dementia.

Forskningsparken - Oslo Science Park

Place: G﻿austatoppen, Oslo Science Park 1﻿2:30: Wraps and coffee will be served. Welcome 13:00C﻿hairsJan Terje Andersen, the Laboratory of Adaptive Immunity and HomeostasisBjarte Reve, Nansen Neuroscience NetworkHenrik Peersen, Norwegian Brain Council13:10-13:40Trim-Away: Targeted degradation of proteins and pathogens by TRIM21Leo JamesMRC Laboratory of Molecular Biology, Cambridge, UKTRIM21 is a unique protein that is both an antibody receptor and E3 ubiquitin ligase. This combination of activities allows TRIM21 to protect cells from infection and makes it ideally suited for targeted protein degradation technologies (eg Trim-Away). By uncovering the molecular mechanisms by which TRIM21 labels its substrates and degrades them, we hope to understand its role in natural immunity and apply this knowledge to the design of new therapeutics. 13:40-14:10The application of intracellular immunity for new therapeutic approaches in neurodegenerative diseasesWilliam McEwanSir Henry Dale Fellow and UK Dementia Research Institute Group Leader UK Dementia Research Institute at the University of Cambridge, UKTau pathology is a driving feature of several common neurodegenerative diseases including Alzheimer’s disease. We find a critical role for intracellular immunity in limiting the spread of tau. We are advancing a deeper understanding of this active cytosolic defense for the development of new therapeutic approaches. 14:10-14:25Type-I interferon exacerbates tau pathology by potentiating seeded tau aggregationSophie Sanford, PhD Student, McEwan GroupUK Dementia Research Institute at the University of Cambridge, UKThe antiviral type-I interferon (IFN-I) response is stimulated by the detection of virus-and damage-associated molecular patterns. Signatures of IFN-I-driven gene expression are observed in the brain of patients suffering from neurodegenerative diseases including Alzheimer’s disease. However, the role of IFN-I in the progression of tau pathology remains unknown. We demonstrate that the IFN-I response drives tau pathology by rendering neurons highly vulnerable to seeded aggregation. This identifies the IFN-I response as a potential link between amyloid and tau pathologies and as a therapeutic target for modulation of disease pathology.15 min break14:40-15.10The ageing angle of Alzheimer’s disease and drug developmentEvandro Fei FangGroup Leader, Associate Professor, Department of Clinical Molecular Biology, University of Oslo and Akershus University HospitalAgeing is the highest risk factor of neurodegenerative diseases, including Alzheimer’s disease. The Fang lab applies the hallmarks of ageing to untangle the aetiology of Alzheimer’s disease and for drug development. A few drug candidates developed are in clinical trials. 15:10-15:25TRIM7 detects a C-terminal degron in human and viral proteins Jakub LuptakMRC Laboratory of Molecular Biology, Cambridge, UKTRIM7 binds and degrades diverse substrates by recognising a simple dipeptide sequence at protein C termini. This means around 1% of the human proteome is a potential substrate as well as a range of viral proteins that are generated during polyprotein processing by 3C-type proteases. But what is TRIM7’s physiological role?The seminar is organized by the Laboratory of Adaptive Immunity and Homeostasis, Nansen Neuroscience Network, Norwegian Brain Council, the Life Science Cluster and Norwegian Society for Immunology

A dive into the cell – New opportunities for treatment of dementia

More events from The Laboratory of Adaptive Immunity and Homeostasis

Discover more events from The Laboratory of Adaptive Immunity and Homeostasis, from Science & Tech to other experiences you might love.

Still looking for the right event?

Explore all events in Ullevål and filter by date, category, and more to find the perfect fit.

A dive into the cell – New opportunities for treatment of dementia

More events from The Laboratory of Adaptive Immunity and Homeostasis

Discover more events from The Laboratory of Adaptive Immunity and Homeostasis, from Science & Tech to other experiences you might love.

You might also like...

Browse more events with different dates, prices, and formats to find your next great experience.

Still looking for the right event?

Explore all events in Ullevål and filter by date, category, and more to find the perfect fit.