TRANSGENERATIONAL INHERITANCE OF PATHOGEN AVOIDANCE

Simons Foundation Presidential Lectures

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Simons Foundation

<h2>The 'Transgenerational Inheritance of Pathogen Avoidance or: How Getting Food Poisoning Might Save Your Species' lecture is part of The Neuroscience of Decision Making Presidential Lecture Series in Neuroscience and Autism Science.</h2>

Our experiences influence our decisions, but can they influence our descendants' decisions? Animals must distinguish pathogens from nutritious food sources; this is particularly challenging for C. elegans, which must distinguish bacterial food from pathogens among the many bacteria in its environment.In this lecture, Coleen Murphy will present how she and her colleagues found that a single exposure to purified small RNAs isolated from pathogenic Pseudomonas aeruginosa (PA14) is sufficient to induce pathogen avoidance in the treated worms and four subsequent generations of progeny. The RNA interference (RNAi) and PIWI-interacting RNA (piRNA) pathways, the germline and the ASI neuron are all required for avoidance behavior induced by bacterial small RNAs and for the transgenerational inheritance of this behavior. A single P. aeruginosa non-coding RNA, P11, is necessary and sufficient to convey learned avoidance of PA14, and its C. elegans target, maco-1, is required for avoidance. Their results suggest that this non-coding-RNA-dependent mechanism evolved to survey the microbial environment of the worm, use this information to make appropriate behavioral decisions and pass this information on to its progeny.<a href="https://molbio.princeton.edu/people/coleen-t-murphy" target="_blank" data-msys-clicktrack="0" rel="nofollow noopener noreferrer">Murphy</a> graduated from the University of Houston with a B.S. in biochemistry and biophysics and earned her doctorate in biochemistry at Stanford University. She then did her postdoctoral work at the University of California, San Francisco, where she identified the set of genes downstream of the insulin signaling/FOXO longevity pathway. She is the James A. Elkins, Jr. professor in the life sciences at Princeton University and director of the Simons Collaboration on Plasticity and the Aging Brain.Murphy's team has developed C. elegans models of human "quality of life" aging phenotypes, including cognitive aging and reproductive aging. She and her colleagues have also identified remarkably well-conserved genetic pathways that can extend these processes with age.To attend this in-person event, you will need to register in advance and provide:<ul><li>Acceptable proof of vaccination (vaccine card/certificate, a copy or photo of vaccine card/certificate or electronic NYS Excelsior Pass or NJ Docket Pass)</li><li>Photo ID</li><li>Eventbrite ticket confirmation email with QR code</li><li>Simons Foundation Health Screening Questionnaire approval email</li></ul>Guests are expected to complete these requirements each time they visit the Simons Foundation and entrance will not be granted without this documentation.On-site registration will not be permitted. Walk-in entry will be denied.SCHEDULEDoors Open: 5:30 p.m.Lecture: 6:00 p.m. – 7:00 p.m.The Gerald D. Fischbach Auditorium complies with the Americans with Disabilities Act and offers accessible seating to visitors with special access needs.

<aside><a href="https://www.simonsfoundation.org/sf-events/?type=simons-foundation-lectures" target="_blank" data-msys-clicktrack="0" rel="nofollow noopener noreferrer">Simons Foundation Presidential Lectures</a> are free public colloquia centered on four main themes: Biology, Physics, Mathematics and Computer Science, and Neuroscience and Autism Science. These curated, high-level scientific talks feature leading scientists and mathematicians and are intended to foster discourse and drive discovery among the broader NYC-area research community. We invite anyone interested in the topic to join us for this weekly lecture series.</aside><aside><a href="http://eepurl.com/hS7ngv" target="_blank" data-msys-clicktrack="0" rel="nofollow noopener noreferrer">Sign up here</a> to receive Simons Foundation Presidential Lectures announcements and reminders.</aside>

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TRANSGENERATIONAL INHERITANCE OF PATHOGEN AVOIDANCE

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