What is Limb-Girdle Muscular Dystrophy, type 2D / R3?

Limb-Girdle Muscular Dystrophy (LGMD) is a group of rare muscular disorders that generally present with weakness in the hips and shoulder muscles. LGMD2D / R3 is an autosomal recessive disease caused by alpha-sarcoglycan gene mutations that lead to a functional alpha-sarcoglycan protein deficiency. LGMD2D is one of the most severe forms of limb-girdle muscular dystrophies.

Currently, no treatments are available for LGMD2D patients to help slow or stop disease progression.

The LGMD2D Foundation is a registered 501(c)3 non-profit foundation built for families living with LGMD2D - both patients and caregivers - by families with the same diagnosis. Our mission is to expedite the development of treatments or a cure for Limb-Girdle Muscular Dystrophy, type 2D / R3 (LGMD2D).