Streamlining Cell Line Development for Faster Biologics Production

Efficient cell line development remains one of the most critical challenges in biotherapeutic manufacturing.

Achieving stable, high-yield expression systems while maintaining product quality and regulatory readiness can significantly impact development timelines and overall program success.

This webinar will explore advanced strategies that streamline every stage of cell line development and process optimization, using transposase-based expression technology designed to enable the stable, non-random integration of multiple copies of expression constructs into CHO-K1 cells.

Accelerated development is enabled by the transposase-mediated stable integration that maintains structural integrity, with the stable pool identically expressing product subunits.

A strong productivity and product quality comparability between the pools and the derivative stable clones allowing for the earlier production of representative drug material in quantities suitable for toxicology and preclinical studies.

The featured speakers will also discuss integrated, end-to-end development strategies that accelerate biologics programs targeting complex or previously difficult-to-address antigens.

Through multidisciplinary collaboration across discovery, pharmacology, preclinical and technical development functions, the workflow demonstrates how synchronized CHO cell line and upstream process development can reduce risk, improve tech transfer and enhance scalability.

Beginning with stable pools, this process supports efficient generation of representative material for early safety studies and facilitates alignment between clone selection, process optimization and downstream manufacturing.

Register for this webinar to learn how streamlined cell line development supports faster, more reliable biologics production and smoother transition to clinical manufacturing.

Keywords: Bioanalytical Testing, Biologics, Biologics Development, Biologics Manufacturing, CDMO/CMO, Cell Line Development, Drug Development, Pre-Clinical, Process Development, Quality, Regulatory