The idea that memory might be encoded as changes in the cell nucleus, particularly as alterations in DNA or RNA, has a long history. Currently, however, the synaptic model of memory storage predominates within neuroscience. But recent evidence from studies of epigenetic changes associated with the storage of long-term memory has led to a renewed interest in the idea of nuclear storage of memory.

David Glanzman will present the results of recent experiments from his laboratory regarding the mechanisms of long-term memory in the model invertebrate organism Aplysia. These results indicate that the consolidation and maintenance of long-term memory depends critically on an epigenetic change, specifically, DNA methylation. In addition, Glanzman will describe how DNA methylation appears to regulate the occult persistence of memory after its apparent erasure, and discuss the implications of this discovery for treating disorders of memory.

Light refreshments will be served. Parking on campus is $12 per vehicle.

David L. Glanzman is a professor at UCLA in the departments of Integrative Biology and Physiology, and Neurobiology.