Glial and Neuronal Biology of the Aging Brain

Join us for a joint Alana Down Syndrome Center and Aging Brain Initiative symposium on October 5-6, 2022. The topic this year will be Glial and Neuronal Biology of the Aging Brain.

Talks will continue today at 9am ET and the session will conclude with a virtual poster session on Airmeet from 12:15-1:15pm. Please see below for poster session details.

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Webcast Link

This will be a virtual event viewable via webcast.

WEBCAST LINK: https://web.mit.edu/webcast/alana-abi/f22/

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Poster Session Info & Link

A poster session featuring 12 trainees working within the Alana Down Syndrome Center and Aging Brain Initiative will follow the conclusion of the speaking program today. Please find the list of posters below the program schedule on this page.

The poster session will be from 12:15-1:15pm ET on the platform AIRMEET. Please see below for the link to join.

PLEASE NOTE: It is important to use Chrome as your browser for the poster session; Airmeet can be glitchy in other browsers. To view a poster and interact with the presenter, join their table by clicking "Join" below the table or clicking an empty seat.

• AIRMEET POSTER SESSION LINK: https://www.airmeet.com/e/82c45930-44ec-11ed-a3cc-55a83607dc26
• PREVIEW POSTERS (Dropbox): https://www.dropbox.com/sh/edcvwr1h1vyc4ib/AABA2wCghumzxscepz-5dzOca?dl=0

Agenda (all times ET)

Wednesday, October 5 | Moderator: Ravikiran Raju, Picower Institute, MIT, Boston Children's Hospital

• 1:00-1:10pm: Opening Remarks, Li-Huei Tsai, Director, Picower Institute, MIT, Director, Aging Brain Initiative and Alana Down Syndrome Center
• 1:10-1:40pm: Beth Stevens, Boston Children's Hospital, Harvard Medical School, "Connecting Microglia States to Function in Health and Disease" 
• 1:40-2:10pm: Li Gan, Weill Cornell Medical College, "Maladaptive Microglia Drive Tauopathy"
• 2:10-2:40pm: Michael Heneka, Luxembourg Centre for Systems Biomedicine (LCSB), "Microglia Derived Tunneling Nanotubes as Live Aid for Neurons"
• 2:40-3:00pm: Break
• 3:00-3:30pm: Elizabeth Head, University of California, Irvine, "Cerebrovascular Pathology as a Function of Age and Alzheimer disease in Down syndrome"
• 3:30-4:00pm: Gilbert Di Paolo, Denali Therapeutics, "Lysosomal Functions of Progranulin and Implications for Treatment of Frontotemporal Dementia" 
• 4:00-4:05pm: Closing Remarks, Emily Niederst, Scientific Director, Alana Down Syndrome Center and the Aging Brain Initiative

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Thursday, October 6 | Moderator: Jackie Yang, MIT

• 9:00-9:10: Opening Remarks, Li-Huei Tsai, Director, Picower Institute, MIT, Director, Aging Brain Initiative and Alana Down Syndrome Center
• 9:10-9:40am: Nancy Yuk-Yu Ip, The Hong Kong University of Science and Technology, "Understanding the Roles of Interleukin-33 in Alzheimer’s Disease: New Therapeutic Insights"
• 9:40-10:10am: Tracy Young-Pearse, Brigham and Women's Hospital, Harvard Medical School , "APP and DYRK1A Regulate Axonal and Synaptic Vesicle Protein Networks and Mediate Alzheimer’s Pathology in Trisomy 21 Neurons" 
• 10:10-10:40am: Shane Liddelow, NYU, "Reactive Astrocyte Responses to Inflammation and Neurodegeneration"
• 10:40-11:00am: Break
• 11:00-11:30am: Myriam Heiman, Picower Institute, MIT, "Single-cell Dissection of the Human Cerebrovasculature in Health and Disease"
• 11:30am-12:00pm: Adam M. Brickman, Columbia University, "White Matter Hyperintensities are a Core Feature of Alzheimer's Disease: Evidence from Late Onset and Genetic Forms" 
• 12:00-12:05pm: Closing Remarks, Emily Niederst, Scientific Director, Alana Down Syndrome Center and the Aging Brain Initiative
• 12:05-12:15pm: Break/Poster Session Set-up
• 12:15-1:15pm: Virtual Poster Session, LINK TO ATTEND