Engineering Peptide Stability Through Azapeptide Synthesis and Applications

Many promising peptides fail because they degrade too easily. This limits their usefulness in drug design and creates significant workflow challenges. This webinar explores how azapeptides and non-natural amino acids can be utilized to engineer more stable molecules, highlighting innovations that enhance peptide stability and facilitate automated synthesis.

Azapeptides are unique because they replace the α-carbon of an amino acid with a nitrogen atom. This small change improves stability, alters hydrogen bonding and reshapes conformation. The Proulx lab has developed synthesis methods to create large azapeptide libraries quickly. The featured speakers will present recent advances, including new N-alkylation techniques and metallo-azapeptide complex formation.

Attendees will learn how to use aza-amino acids in natural peptides and will understand how azapeptides behave differently from traditional peptides. Attendees will also gain insight into the real challenges of using automated synthesizers for complex peptide chemistry.

Register for this webinar to learn how azapeptide strategies can enhance peptide stability and accelerate synthesis workflows.

Keywords: automated peptide workflow, Drug Development, Drug Discovery, high-throughput synthesis, Non-natural peptides, peptide drug discovery, peptide engineering, peptide libraries, peptide purification, peptide scaffolds, Peptide Synthesis, peptide therapeutics, scaffold optimization