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UCL-DEMNET Symposium 2012

Friday, 27 April 2012 from 09:00 to 20:00 (BST)

UCL-DEMNET Symposium 2012

Registration Information

Type End Quantity
Non-Presenting Attendee
Please register using your UCL email address as confirmation of eligibility to attend. If you are a visitor to UCL, please email organiser for details of how to register..
Ended Free  

Event Details










Friday 27th April, 2012  9.00 am


 G06 Sir Ambrose Fleming LT and Foyer, Roberts Bldg UCL

(Opposite Waterstones Torrington Place, entrance in Malet Place)







Sponsored by


9.00 -9.30Coffee and Registration

NB Poster boards available throughout the day. Posters should be put up during registration or during the morning tea break. Poster sessions throughout the day accompanied by refreshments, lunch and wine and food in the evening



9.30-9.35 Welcome and Introduction


9.35-10.35 Session 1 Non Alzheimer's Dementias


Frontotemporal Dementia

Tammaryn Lashley   Clinical and pathological features of frontotemporal dementia linked to C9ORF72 mutations.

Lashley T, Mahoney CJ, Rohrer JD, Rossor MN, Warren JD and Revesz T          

Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology.


Jonathan Rohrer   GENFI - the GENetic Frontotemporal Dementia Initiative     

Dementia Research Centre, UCL Institute of Neurology      


Prion Dementias

Andrew Thompson   Behavioural and Psychiatric Features of the Human Prion Diseases:  Experience in 357 Prospectively Studied Patients.

Thompson AGB, MacKay A*, Rudge P, Lukic A, Porter MC, Lowe J, Gopalakrishnan GS,  Hyare H, Collinge J, Mead S.

MRC Prion Unit, Department of Neurodegenerative Disease, UCL; except * NHS Highland Mental Health Services, Argyll and Bute Hospital, Blarbuie Road, Lochgilphead, Argyll.


Andy Nicoll  Characterisation of the Interaction Between Toxic Amyloid Beta Assemblies and the Cellular Prion Protein

Andrew J. Nicoll, Darragh B. Freir, Igor Klyubin, Silvia Panico, Emmanuel Risse, Mark A. Farrow, Helen R. Saibil, Michael J. Rowan, Dominic M. Walsh and John Collinge.   

Medical Research Council Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WCN1 3BG, UK.



10.35-11.20 Session 2   Alzheimer’s related to other syndromes

Down’s Syndrome and Alzheimer’s Disease

Frances Wiseman  Trisomy of human chromosome 21 and the development of Alzheimer’s disease : a mouse model

Wiseman F1, Sheppard O1, Barkus C2, Pettingill P2, Ruparelia A1, Slender A3, Taylor A2, Bannerman D2, Tybulewicz V3, Fisher EMC1 

1 Department of Neurodegenerative Disease, UCL Institute of Neurology, London

2 Department of Experimental Psychology, University of Oxford              

3 National Institute for Medical Research, Mill Hill, London


Dr Amanda Sinai  The ADSID project – a clinical research database of dementia in older adults with Down syndrome and intellectual disabilities      

Sinai A, Hassiotis A, Bohnen I, Courtenay K, Bass N, Naeem A, McCarthy J, Sharma V, Thomas D, Walker Z, McBrien J, Bernal J, Dodd K, Mukherji K, Bonell S, Blatchford P, Perez-Achiaga N, Whitham S, Strydom A 

Mental Health Sciences Unit, University College London


Age-Related Macular Degeneration and Alzheimer’s Disease

Imre Lengyel  Is the eye a window to the brain in Alzheimer's disease?  

UCL Institute of Ophthalmology        


11.20-11.30 Editors of Alzheimer's Research & Therapy (Biomed Central) introducing the  journal

NB Editors of Alzheimer’s Research and Therapy will be available at all breaks and during the wine receptions and are keen to discuss the journal and the work with individuals.



11.30-12.00 Posters and Morning Coffee/Tea




12.00-1.00 Discussion

John Hardy and Frances Edwards will lead a discussion on this and other subjects. If you have other subjects that you would like to have raised feel free to suggest them and they will be added to the list for discussion



1.00- 2.00pm  Posters and LUNCH sponsored by Alzheimer’s R & T

2.00-3.00 Session 3   Research models

Silvia Purro   The secreted Wnt antagonist Dickkopf-1 is required for Aβ-mediated synaptic loss

Purro S. A,  Dickins E. M. and Salinas P.C. 

Department of Cell and Developmental Biology, UCL         


Damian Cummings  Similarities and differences in early synaptic changes in models of dementia.

Damian Cummings1, ,Zelah Joel1 , Amy Nick1,  Taylor Hanan1, Jill Richardson2 and Frances Edwards1

1Dept Neuroscience Physiology and Pharmacology, UCL, Gower St London WC1E 6BT

2Glaxo Smith Kline


Tatania Papkovskaia  G2019S Leucine Rich Repeat Kinase 2 mutation upregulates uncoupling protein mediated mitochondrial uncoupling.      

Papkovskaia T.D., Chau K., Hardy J., Papkovsky D. P., Duchen M., Alessi DR., Schapira AHV., Cooper J

UCL and University of Dundee, University College Cork


Kerri Kinghorn  Dissecting the role of PLA2G6 mutations in Parkinson's disease in Drosophila melanogaster

Kerri J. Kinghorn, Jorge I. Castillo-Quan, Shabana Khan, Xun Choong, Linda Partridge and John Hardy

Institute of Neurology, UCL   



3.00-3.30  Afternoon tea


3.30- 4.15 pm PLENARY LECTURE

Professor Sir Mark Pepys

Director, Wolfson Drug Discovery Unit, Centre for Amyloidosis & Acute Phase Proteins

Division of Medicine, Royal Free Campus

Serum amyloid P component (SAP):  A new therapeutic target in neurodegenerative disease



4.15-5.00  Updates on recent major funding

Martin Rossor  Director of Dementia Research Centre, ION

Outlining plans for the recent award from NIHR for a UCL Biomedical research Unit (BRU) in Dementia Experimental Medicine


Nick Fox   Professor of Clinical Neurology and Neurosurgery, IoN

Outlining plans for the Leonard Wolfson Experimental Neurology Centre at UCL



5.00 onwards Posters and Wine Reception sponsored by Eisai

Posters (in alphabetical order of presenter)


1. Pathogenic effects of Aβ on gene expression mediated by Dkk1     

Raya Al-Shawi1, Richard Killick2, Elena M. Ribe2, Bilal Malik2, Claudie Hooper2, Patrick M. Nolan3, John Stephenson2, Simon Lovestone2, J. Paul Simons1.

1Department of Inflammation, Division of Medicine, UCL, Royal Free Campus, NW3 2PF



2. The neuronal ceroid lipofuscinoses (Batten disease)

Michael E. Bond, Vieira, M., Marotta, D., kleine Holthaus, S. and Mole, S. E.       

MRC Laboratory for Molecular Cell Biology, Molecular Medicine Unit, UCL Institute of Child Health and Department of Genetics, Evolution and Environment, UCL, London WC1E 6BT



3. Healthy lifespan effects of lithium treatment in a Drosophila model of neurodegeneration

Jorge I Castillo-Quan, Bjedov I, Li L, Kinghorn KJ, Hardy J, Partridge L  

Institute of Healthy Ageing, Department of Genetics Evolution and Environment. UCL. Department of Molecular Neuroscience. Institute of Neurology. Queen Square



4. Dopamine modulates episodic memory persistence in old age        

Rumana Chowdhury, Guitart-Masip, M, Bunzeck, N, Dolan, R, Düzel, E 

Institute of Cognitive Neuroscience, Wellcome Trust Centre for Neuroimaging, University Medical Center Hamburg-Eppendorf, Otto-von-Guericke-University Magdeburg, German Center for Neurodegenerative Diseases            



5. Early synaptic changes in AD models are similar in mice with very different genotypes

Zelah Joel1, Damian Cummings1, Taylor Hanan1, Jill Richardson2 and Frances Edwards1

1Dept Neuroscience Physiology and Pharmacology, UCL, Gower St London WC1E 6BT

2Glaxo Smith Kline



6. Systematic Review of the Effectiveness of Sensory, Psychological and Behavioural Interventions for Managing Agitation in Older Adults with Dementia        

G. Livingston 1,*, C. Cooper 1, C. Katona 1, Lynsey Kelly 1, E. Lewis-Holmes 1, S. Morris 2, R. Omar 3           

1Mental Heath Sciences, 2Epidemiology and Public Health , 3Dept of Statistical Science, UCL,



7. PRP antibodies do not trigger mouse hippocampal neurone apoptosis

Klöhn PK, Michael Farmer, Linehan JL,  O'Malley CO, Fernandez de Marco MF, Taylor WT, Farrow MF, Khalili-Shirazi AK, Brandner SB, Collinge JC          

MRC Prion Unit, Institute of Neurology, UCL  Queen Square London         



8. Do changes in coping style explain the effectiveness of interventions to reduce psycholological morbidity in family carers of people with dementia? A systematic review and meta-analysis         

Ryan Li, Cooper, C., Austin, A., Livingston, G.        

UCL Mental Health Sciences



9. Coping strategies and psychological morbidity in family carers of people with dementia: A systematic review and meta-analysis   

Ryan Li., Cooper, C., Bradley, J., Shulman, A., Livingston, G.       

UCL Mental Health Sciences



10. Generation of a cell bank of dementia patient-derived fibroblasts 

Elizavet Preza, Wray S, Mahoney C, Ryan N, Liang Y, Morris H, Houlden H, Hardy J and Rossor M

1. Dept of Molecular Neuroscience, UCL Institute of Neurology 2. Dementia Research Centre, Dept of Neurodegeneration, UCL Institute of Neurology 3. Dept Neurology, University Hospital Wales, Cardiff University           



11. Eye tracking in Posterior Cortical Atrophy: a new insight into the visual syndrome.

Tim Shakespeare, Crutch, S.          

Dementia Research Centre   



12. Examining reading deficits in Posterior Cortical Atrophy   

Keir Yong, Sebastian Crutch, Prof. Elizabeth Warrington   

Dementia Research Centre, Institute of Neurology, UCL



13. Selective preservation of reading in Posterior Cortical Atrophy    

Keir Yong, Elizabeth Warrington, Sebastian Crutch

Dementia Research Centre, Institute of Neurology, UCL

Do you have questions about UCL-DEMNET Symposium 2012? Contact the organiser

When & Where

Sir Ambrose Fleming LT, Roberts Building
Univeristy College London
Malet Place
WC1E 6BT London
United Kingdom

Friday, 27 April 2012 from 09:00 to 20:00 (BST)

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