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Symposium to Honor Dr. Istvan Lengyel

St. John's University Chemistry Department

Saturday, November 9, 2013 from 1:00 PM to 5:00 PM (PST)

New York, NY

Symposium to Honor Dr. Istvan Lengyel

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Dr. Lengyel Symposium 101 Tickets Ended Free  

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Event Details

Speakers:

1:00pm            Welcoming Remarks.

1:15pm            William Pitts, R.Ph., Ph.D., Senior Principal Scientist Immunology Chemistry at Bristol-Myers Squibb.

Title: Molecular Modeling, Synthesis & Medicinal Chemistry.

Abstract: This presentation will focus on the interplay between molecular modeling and synthetic organic chemistry to aid medicinal chemistry efforts.  Syntheses of target molecules and relevant pharmacology in the areas of  HIV protease,  MEK, IMPDH, MMP-13, and  IKappa B Kinase will be discussed.

 

2:00pm            Dr. Peter Gorycki, Ph.D., Director, Biotransformation at GlaxoSmithKline

Title: TBA.

Abstract:

 

2:45pm            Coffee Break

 

3:15pm            Tony Taldone, Ph.D., Senior Research Scientist at Memorial Sloan-Kettering

Cancer Center

Title: Discovery and Development of Purine-scaffold Hsp90 inhibitors for the Treatment of Cancer. Abstract: Heat shock protein 90 (Hsp90) is a molecular chaperone exploited by cancer cells to aid in their survival. The recognition of Hsp90 as a critical facilitator for oncogene addiction and survival of cancer cells has opened a promising new niche for cancer treatment. The serendipitous discovery that the broad spectrum anticancer activity of the natural products geldanamycin (GM) and radicicol (RD) was a result of inhibition of Hsp90 resulted in the development of improved derivatives of these natural products. One of these was 17-AAG, a closely related analog of GM, and was in fact the first Hsp90 inhibitor to enter the clinic. However, GM and its analogs suffer from poor "drug-like" properties and this served as a strong impetus for the development of novel synthetic Hsp90 inhibitors. One class to exhibit enhanced potency and improved pharmacokinetic properties is the purine-scaffold. A number of small-molecule Hsp90 inhibitors based on the purine-scaffold are currently being evaluated in clinical trials for cancer. Here, I will discuss their initial discovery and development into potential anticancer agents.

4:00pm            Victor Cesare, Ph.D., Professor at St. John’s University

Title: The Chemistry of a-Lactam According to Dr. Istvan Lengyel

Abstract: Dr. Lengyel was a pioneer and leader in the field of a-lactam chemistry for over 40 years.  This talk will highlight is contributions starting with his Ph.D. work at MIT and concluding with his 10 year collaboration with this speaker.

5:00pm           Dinner for students, speakers, guests             Location: TBA

Have questions about Symposium to Honor Dr. Istvan Lengyel? Contact St. John's University Chemistry Department

When & Where



St. John's University, Bent Hall 277A/B
80-00 Utopia Pkwy
New York, NY 11439

Saturday, November 9, 2013 from 1:00 PM to 5:00 PM (PST)


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St. John's University Chemistry Department

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