Seminar: Margaret Brandeau
Friday, December 4, 2015 from 11:30 AM to 1:00 PM (EST)
Cost-Effectiveness of HIV Preexposure Prophylaxis for Injection Drug Users in the United States
Margaret L. Brandeau
- Coleman F. Fung Professor of Engineering, Stanford University
- Professor of Medicine (by Courtesy), Stanford University
Recent CDC guidelines recommend that clinicians consider any adult who has injected drugs or been enrolled in opioid replacement therapy in the past 6 months eligible for HIV preexposure chemoprophylaxis (PrEP). However, the potential population health benefits, costs, and value of implementing the CDC recommendation remain unclear. We developed a dynamic model of the HIV epidemic in the United States to evaluate oral PrEP (Truvada) for injection drug users (IDUs). We find that introducing PrEP for 50% of the uninfected IDU population over a 20-year time horizon would cost more than $200,000 per QALY gained. If the release of a generic drug halved PrEP’s cost, then even at moderate efficacy levels, PrEP for IDUs would cost approximately $100,000 per QALY gained.Scenario analyses show that PrEP is most valuable when combined with frequent screening and access to treatment should an individual become infected. We conclude that PrEP for IDUs can provide substantial health benefits for the entire US population, but at the current cost of Truvada is a very expensive intervention.
About the Speaker
Margaret Brandeau is the Coleman F. Fung Professor of Engineering and Professor of Medicine (by Courtesy) at Stanford University. Her research focuses on the development of applied mathematical and economic models to support health policy decisions. Her recent work has focused on HIV prevention and treatment programs, programs to control the spread of hepatitis B virus, and preparedness plans for bioterror response. She is a Fellow of the Institute for Operations Research and Management Science (INFORMS) and a member of the Omega Rho International Honor Society for Operations Research and Management Science. From INFORMS she has received the President’s Award (recognizing important contributions to the welfare of society), the Pierskalla Prize (for research excellence in health care management science), the Philip McCord Morse Lectureship Award, and the Award for the Advancement of Women in Operations Research and the Management Sciences. She has also received the Award for Excellence in Application of Pharmacoeconomics and Health Outcomes Research from the International Society for Pharmacoeconomics and Outcomes Research, and a Presidential Young Investigator Award from the National Science Foundation, among other awards. Professor Brandeau earned a BS in Mathematics and an MS in Operations Research from MIT, and a PhD in Engineering-Economic Systems from Stanford University.
Lunch will be provided
When & Where
Center for Interdisciplinary Research on AIDS at Yale University
CIRA is supported by National Institute of Mental Health Grant No. P30MH062294.
Paul D. Cleary, Ph.D., Principal Investigator