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SCGPM Seminar: Deanna Church, 10X Genomics
Tue, February 16, 2016, 12:30 PM – 1:30 PM PST
Analyzing individual genomes
Deanna Church, 10X Genomics
ABSTRACT: In the 13 years since the completion of the genome project, 100s of thousand of genomes and exomes have been analyzed. However, despite this incredible progress, as a community we are still trying to find the missing diagnostic yield as well as the missing heritability. In this presentation, I'll discuss limitations in the current ways we approach genome analysis. In addition to discussing the state of de-novo assembly for genome analysis, I'll discuss ways to improve reference-based analysis, including the use of GRCh38.
BIO: Dr. Deanna Church is currently the Senior Director of Applications at 10X Genomics. In this role, she leads a group of scientists developing improved approaches to genome analysis using linked read technology as well as applications in single cell analysis. Previously, she was Senior Director of Genomics and Content at Personalis. Prior to that, she was a staff scientist at NCBI, where she oversaw several projects concerning managing and displaying genomic data, including dbVar, a database of genomic structural variation, the NCBI Map Viewer, the Clone database, and the NCBI Remap service. Dr. Church was also a member of the Genome Reference Consortium (GRC) an international consortium charged with improving the human, mouse, and zebrafish assemblies, and was an author on the two seminal manuscripts describing the human and mouse genome sequences. She has experience in molecular biology, genetics, genomics, bioinformatics, and is currently focusing on improving genome analysis. She graduated from the University of Virginia with a BA in Liberal Arts in 1990, and received her doctoral degree in the Biological Sciences at the University of California, Irvine in 1997 with Dr. John Wasmuth. She performed postdoctoral work with Dr. Janet Rossant at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital in Toronto.
ABOUT THE SCGPM: The Stanford Center for Genomics and Personalized Medicine (SCGPM) seeks to advance genomic technology so that someday both genetic and molecular profiling will become powerful and routine tools for predicting disease risk and monitoring and treating a wide range of pathologies. Towards this mission, the SCGPM serves to centralize and develop collaborative intellectual and technological resources that promote genomic research and analysis, predict drug response, educate physicians, and examine the ethics of personalized medicine. This includes large basic science projects such as ENCODE that decipher the human genome as well as clinical research projects such as the sequencing of cancer genomes and individuals with inherited diseases. Through these efforts, the Center aims to bring genomics to the clinic.
For more information about the SCGPM, go to scgpm.stanford.edu.