Though sometimes necessary during episodes of sustained aggression or self-injurious behavior, it is in everyone’s interest to minimize the use of physical restraint and seclusion. Following the use of these reactive measures, teams traditionally conduct a type of autopsy, describing the conditions immediately before, during, and after and assessing whether changes can be made the next time challenging behavior ensues. These reviews are appropriate, but insufficient. In this workshop, we will discuss variables relevant to de-escalation. But, our primary focus will be on broader interventions, with particular focus on establishing foundational learner repertoires that decrease the likelihood of unsafe behaviors.