€189.96 – €882.08

PBPK Modeling and quantitative in vitro-in vivo extrapolations

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RIKILT Wageningen University and Research

Akkermaalsbos 2

6708 Wageningen

Netherlands

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Draft agenda available here.

Physiologically based pharmacokinetic (PBPK) modelling plays a crucial role in next generation (non-animal) risk evaluations to inform the design of in vitro studies and to convert the data obtained with in vitro models into human dose−response or potency information. The goal of the course is to acquaint participants with setting up PBPK models based on non-animal input parameters and to subsequently use these models to extrapolate in vitro bioassay data to human dose-response or potency information.

The course consists of:

- Lectures that cover the basic principles of PBPK model-development and the application of PBPK modelling in different fields (e.g. safety evaluations of pharmaceuticals and industrial chemicals, development of alternatives to animal testing).

- Hands-on experience focussing on how to derive adequate chemical-specific input parameters.

- Hands-on experience with developing PBPK models in Berkeley Madonna software.

- Hands-on experience with developing PBPK models with Simcyp’s Population-based Simulator.

- Use of the models to extrapolate in vitro bioassay results to human dose-response or potency information

The training will only take place if minimum of 8 participants is reached.

FAQs

What's the refund and cancellation policy?

Refunds are available only if Altertox Academy cancels the event. This is stated on the participant’s receipt once registered. However, tickets may be transferable if the ticket holder is unable to attend the event. In principle the ticket may only be transferred within the same price category but a final decision will be made at Altertox Academy's discretion.

Do I actually manipulate in the lab?

Each hands-on training is scheduled to last for 2-Days. In these two days, the hands-on trainings encompass 20% Lectures and 80% Laboratory practices. In other words, for about more than a day and a half of the trainings each participant will able to actively manipulate in the laboratory in small groups of 3-4 people. Therefore, some preliminary knowledge for cell culture in the lab is mandatory.

What is the difference between “private” sector and “non-private” sector?

The participant must choose the "private” sector in case his/her organization has any commercial activities e.g. selling products or services to third parties.

What is a "webinar" ticket?

The webinar ticket allows you to follow live the lectures that take place in the morning of the first day of training through an online platform specified by Altertox Academy before the training begins.

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Date and Time

Location

RIKILT Wageningen University and Research

Akkermaalsbos 2

6708 Wageningen

Netherlands

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