NUTRITIONAL GENOMICS CONFERENCE
Wayne R Bidlack, Ph.D, Professor, Department Human Nutrition and Food Science, California State Polytechnic University, Pomona.
Raymond Rodriguez, Ph.D, Director, Center of Excellence in Nutritional Genomics, University of California, Davis
November 12-14, 2009
NUTRITIONAL GENOMICS CONFERENCE:
The Impact of Dietary Regulation of Gene Function on Human Disease
Today it is not uncommon to discuss the etiology of human disease in the context of genes, environment, and nutrition. With the sequencing of the human genome and the rapid scientific advances that followed, researchers have been able to explore the linkage between diet and those molecular processes that govern long-term health and disease outcomes. While the presence of a particular gene variant may indicate a predisposition to a particular disease, the expression of the disease phenotype will depend on the complex interplay between external factors and the molecular components that regulate expression of specific genes. To fulfill the promise of nutritional genomics, researchers must reconcile the diverse properties of dietary signals (metabolites and peptides) with our current knowledge of regulatory gene networks that control higher-order disease traits. In addition to increasing our understanding of the inherited basis of disease, nutritional genomics also promises to revolutionize the way we manage health and disease risk with genome based dietary recommendations and other lifestyle changes.
While knowledge of human genome sequence is required for nutritional genomics, it is not sufficient to fully understand diet x genome interactions and how they relate to diseases such as obesity, hypertension, type 2 diabetes, cardiovascular disease and cancer. Researchers will need a more integrative view of the human genome, and how it interacts with the environment, if they hope to understand the more subtle mechanisms by which nutritive and non-nutritive bioactives impact gene regulatory processes and the physiologies they control. With this understanding will come opportunities to develop nutritional interventions and dietary recommendations that will enable individuals to achieve optimal health earlier, and maintain it longer, with evidence-based nutrigenomic diets. The ultimate goal will be to use whole foods in our diet to prevent some of the catastrophic health outcomes currently overtaking our children and impacting their future health and longevity. This focus on personalized nutrition will have important implication for the agricultural and food industries.
The commercialization of nutritional genomic products and services is already underway. It is imperative, therefore, that leaders in health care, professional societies, and government agencies be aware of recent advances in nutritional genomics so they can properly evaluate the scientific merit of personalized diets and provide guidance to those consumer who wish to tailor their diets to their individual genetic makeup.
The primary goal of this conference will be to provide a platform for researchers, scientists, educators, dietitians, health care professionals and policy makers to discuss the current status of nutritional genomic research. Renowned experts in the field will address the latest scientific findings on the mechanisms underlying diet-genome interactions. Challenges to the potential application of nutritional genomics to improve the nutritional value of the food supply and to address public health issues will be emphasized throughout the program. The final session of the conference will identify future directions for nutritional genomics research as well as challenges and opportunities for improving global health and wellness by preventing, delaying or mitigating chronic diseases and cancer with diet.
The conference program is divided into three themes that will focus the following topics.
Theme I: Transducming Dietary Signals Into Disease Preventing Changes in Gene Expression
Theme I. Transducing Dietary Signals into Disease-Preventing Changes in Gene Expression: This theme will focus on new perspectives and approaches to understanding diet x genome interactions as a complex system of gene networks that modulate the metabolic pathways causing chronic disease. The opening session describes the role of “omics” to identify molecular targets that affect gene expression. Epigenetic changes associated with chromatin remodeling and regulation of gene expression underlie the developmental programming of metabolic balance. The effect of diet and nutrition may predetermine the expression of metabolic syndrome. Reprogramming of the epigenome may enable expression of chemopreventive genes. New bioinfomatic tools for analyzing and identifying key regulatory control points of multiple gene networks will be discussed. Examples of nutritive and non-nutritive bioactives acting on signal transduction pathways and chromatin modification complexes to alter multiple physiological systems will be provided.
Thursday, November 12, 2009
7:30 AM Registration & Continental Breakfast
8:15 AM Welcome and Introduction to Conference
Wayne R. Bidlack, Ph.D.
Organizer, Professor Human Nutrition and Food Science, Cal Poly Pomona, CA
Session I.1 Wayne Bidlack, PhD, Session Chair
8:30 AM Using the “Omics” of Nutrition to Identify Molecular Targets
Sharon Ross, Ph.D. MPH
Program Director, Cancer prevention Division, NIH/NCI, Bethesda, MD
9:30 AM Epigenomics in Diabetes, Metabolic Memory and Their Inflammatory Complications
Rama Natarajan, Ph.D., F.A.H.A., F.A.S.N., Division of Diabetes, Endocrinology and
Metabolism, City of Hope Hospital, Duarte CA.
10:15 AM Break
10:30 AM Diet-informed Epigenetic Modifications: Reprogramming the Epigenome to Express Chemopreventive Genes
Raymond Rodriguez, Ph.D.
Director, Center of Excellence in Nutritional Genomics, UC Davis, Davis, CA
11:15 AM Understanding Diet x Genome Interactions as Complex Systems: A Systems Biology Approach.
Jun Zhu, Ph.D.
Sage Bionetwork, Seattle WA
Session 1.2 Raymond Rodriguez, Ph.D. Session Chair
1:00 PM Modulation of Atherosclerosis by Omega-3 Polyunsaturated Fatty Acids
Darshan Kelley, Ph.D.
WHNRC/Immunity and Disease Prevention Research Unit
ARS/USD, Department of Nutrition, UC Davis, Davis, CA
1:45 PM Analysis of Omega-3 Fatty Acid-Responsive Gene Expression and Pathways
Kevin Dawson, Ph.D.
Chief Informaticist, Center of Excellence in Nutritional Genomics, UC Davis
2:30 PM Break
3:00 PM Nuclear Receptors Coactivators: Physiology, Metabolism and Disease
David M . Lonard, Ph.D.
Assistant Professor, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX
3:45 PM To D or Not to D: Vitamin D and Cardiovascular Disease
Keith C. Norris, MD, FACP
Program Director for Clinical Research Center & Comprehensive Center for Health Disparities in Chronic Kidney Disease, Charles Drew University of Medicine and Science,
4:30 PM Closing
4:45 PM Registered Dietitians and Dietetic/Nutrition Students Discussion of Nutritional Genomics
Theme II. Gene Linked Networks of Chronic Disease and Cancer
Theme II. Gene Linked Networks of Chronic Disease and Cancer: This theme will discuss varied mechanisms of gene expression related to chronic disease, inflammation and cancer. The link between obesity and inflammation with adipose tissue begins with gene expression regulated by Peroxisome Proliferator-Activator Receptors (PPARs). Insulin resistance may result from Adipose-macrophage stimulation of inflammation. Type 2 diabetes affects gene networks altering transcription of genes into proteins. In addition, network analysis of gene expression identified sites affecting Breast Cancer Cells. Dietary effectors alter signal transduction pathways decreasing cancer development. For example, Green tea polyphenols prevent skin cancer.
Additional natural bioactive compounds discussed throughout the program include ω-3 fatty acids, carotenoids, anthocyanins, resveratrol and chocolate polyphenols. They are found in physiologically active amounts in our food and can alter expression of multiple genes affecting chronic disease development. In addition, the human intestinal microbiome can affect the etiology of inflammation and related diseases. Importantly, probiotics can affect the expression of inflammation genes.
Friday, November 13, 2009
8:00 AM Continental Breakfast
8:25 AM Introduction
Session II.1 Gale Strasburg, Ph.D, Session Chair
8:30 AM The Genetics of Metabolic Syndrome and the link to T2DM and Obesity
Margarita Teran-Garcia, MD, Ph.D.
Department of Food Sciences and Human Nutrition
University of Illinois at Urbana-Champaign
9:15 AM Nutrigenomics of Fatty Acid Sensing: Role of PPARs
Sander Kersten, Ph.D.
Assoc. Professor, Nutrition, Metabolism and Genomics Group, Division of Human Nutrition
Wageningen University, Netherlands
10:00 AM Break
10:15 AM Effects of Dietary Effectors on Signal Transduction Pathways Related to Cancer
Zigang Dong, MD, DPH
Professor and Executive Director, Cancer Prevention, Hormel Institute
University of Minnesota, Austin MN
Keck Institute of Applied Life Sciences, Claremont, CA
11:00 AM Skin Cancer Chemoprevention by Green Tea Polyphenols
Santosh Kumar Katiyar, Ph.D.
University Alabama, Birmingham, Al 35294
11:45 AM Lunch
Session II.2 Stella Cash, MEd, MS, RD, Session Chair
12:30 PM Bioactive Food Components and the "U" Shaped Health Conundrum: Vitamin D and Folate
as Examples of Friends and Foes.
John Milner, Ph.D.
Chief Nutrition Division, National Cancer Institute, Bethesda, MD
1:30 PM Insulin Resistance and T2DM: Adipose Tissue Macrophage and Inflammation
Jerrold M. Olefsky, MD
Associate Dean Scientific Affairs and Chief, Division Endocrinology and Metabolism,
UCSD, La Jolla, CA
2:15 PM Network Analysis of Gene Expression in Breast Cancer Cells
T. Gregory Dewey, Ph.D.
Finnigan Professor of Applied Life Sciences,
Keck Graduate Institute, Claremont CA
3:00 PM Break
3:15 PM Human Intestinal Microbiome: Etiology of Inflammation Genomics
Roger A. Clemens, DPH
Assoc. Director, Regulatory Science Program, Adjunct Professor, Pharmacology and Pharmaceutical Sciences, School of Pharmacy University of Southern California School of Pharmacy, Los Angeles, CA
4:00 PM The Gut-Brain Connection: Personalized Genomics and Nutrition Therapy
Colleen Fogarty Draper, MS, RD, LDN
President/Founder, Integrative Nutrigenomics, Nugenso Company, Boston, MA
4:45 PM Closing
5:00 PM Reception Hors d’oeuveres and open bar.
Theme III: Role of Food Science and Nutrition to Meet Individual Genomic Health Needs.
Theme III. Role of Food Science and Nutrition to Meet Individual Genomic Health Needs: This theme will discuss the key role played by the agriculture and food industries to deliver whole foods containing the requisite bioactive components. Genomic plant breeding is used to improve nutritional quality and to enhance bioactive functional foods. Grapes contain resveratrol which can alter gene patterns and improve physiologic response decreasing aging and altering cancer development, and cocoa (dark chocolate) contains high amounts of polyphenols that exceeds antioxidant effects in providing cardiovascular health through altered gene expression. The manufacture of functional foods is a major consideration in the delivery of bioactive food components in an active form assuring they are readily available. Processing has enabled creation of a palatable whole grain liquid, which can be readily incorporated into a variety of food products to enhance delivery of nutritional genomic components. Of course the category of foods required for nutritional genomic intervention will require reconsideration of food labels. These quality foods are good for all consumers, but a simplified identification symbol is needed to enable individuals with specific genomic issues to construct a healthy diet specifically to delay or prevent chronic disease and cancer.
Saturday, November 14, 2009
8:00 AM Continental Breakfast
8:25 AM Introduction
Session III.1 David W. Still, Ph.D., Session Chair
8:30 AM Calcium Biofortification of Crops
Kendal D. Hirschi, Ph.D.
Professor, Department of Pediatrics/Nutrition and Human & Molecular Genetics
Baylor College of Medicine, CNRC, Houston, TX
Professor, Molecular and Environmental Plant Sciences and Assoc. Director, Vegetable and Fruit Improvement Center, College Station Texas
9:15 AM Using Genomics-aided Breeding to Improve Nutritional Content of Lettuce
David W. Still, Ph.D.
Director ARI, Plant Sciences, Cal Poly Pomona, CA
10:00 AM Break
10:15 AM Natural Colorants as Bioactive Agents in Functional Foods
Anne Marie Craig, Ph.D.
Assistant Professor, Food Chemistry, Department HNFS, California State Polytechnic University, Pomona, CA
11:00 AM Resveratrol Alters Global Patterns of Gene Regulation and Improves Physiology
Joseph Baur, Ph.D.
Institute for Diabetes, Obesity and Metabolism, Department of Physiology
University of Pennsylvania School of medicine, Philadelphia, PA
11:45 AM Lunch
Session III.2 Gilbert Leville, Ph.D, and John Floros, Session Co-Chair
12:30 PM Cocoa Supplementation: Formulation Challenges and Measurement of Bioactives
Mary Wagner, Ph.D.
General Manager and Chief Technology Officer for Mars Botanical, Rockville, MD
John D. Floros, Ph.D.
Professor & Head, Department of Food Science, Pennsylvania State University, University Park, PA
2:00 PM New Whole Foods Designed to Deliver Bioactive Components
Cheryl Mitchell, Ph.D.
President, Senior Research Chemist, Creative Research Management, Stockton, CA
2:45 PM Break
3:00 PM Nutritional Genomics and the Future of Food Labeling
Owner and Principal Consultant, Biosciences Translation & Applications,
Cadman Consulting Services, LLC. Colorado
3:45 PM Panel Discussion - Future Potential for Nutritional Genomic Products
Gilbert Leveille, Ph.D. Moderator
Leveille Associates, Scientific and Regulatory Consulting Services to Food Industry
Wayne R. Bidlack, Ph.D. California State Polytechnic University, Pomona, CA
Raymond Rodriguez, Ph.D., Director, Center for Excellence Nutritional
Genomics, UC Davis, Davis, CA
Colleen F. Draper, MS, RD, LDN, Nugenso Company
4:30 PM Conclusion and Acknowledgements
Discussions throughout the program will assess the needs of Personalized Nutrition, targeting specific gene responses, identified after 10 years of research and development. Importantly, the conference concludes with a discussion of the future vision of nutritional genomics identifying research targets and consumer applications.
The conference is targeted to health professionals, educators and researchers interested in Nutritional Genomics as part of their areas of specialization and the future application of these materials in health care. The groups who will benefit most from the information presented include
· Researchers in nutritional science, biological science, genomics, and nutritional genomics, including graduate students, post-doctoral trainees, academic and corporate research professionals
· Dietitians, nutritionist, nurses, public health specialists, physicians, pharmacists, dentists, who are engaged in health care and interact directly with concerned consumers.
· Educators including undergraduate and graduate program faculty, teaching state of the art biological and health sciences from integrating the sciences, new concepts, and new laboratory techniques. The area of nutritional genomics enables integration of a variety of specialty areas, including genetics, molecular biology, nutrition, biochemistry and physiology as the basics to future careers, and the new use of mathematics for development of the bio-infomatics field.
· Policy makers and regulators from state and federal agencies would benefit from a clear understanding of the existing knowledge, and discussions involving creation of needed policy development.