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NIH Workshop on Imaging Inflammation and its Resolution in Health and Disea...

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NIAID Conference Center

5601 Fishers Lane, Rm 1D13

Rockville, MD 20852

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Description

Chronic, unresolved inflammation has been implicated in promoting disease development. A comprehensive assessment of inflammation and resolution states is essential to determine if unresolved inflammation is on the path to causing further harm to the organ sites that are vulnerable to developing diseases. Currently, an individual’s immunological readouts rely on blood tests and histopathological analysis of tissue biopsies, which can be non-specific, invasive, or destructive to the tissue we try to save. Recent advances in medical and molecular imaging techniques can assess immunological phenomena in vivo; many can potentially be adapted and developed to become clinical tools for immunological readouts of vulnerable organ sites within an individual patient.

This workshop brings together practicing physicians, clinical researchers, and imaging tool developers to address the following questions, to identify clinical needs and opportunities, and to align research and development efforts toward in vivo imaging-based tools and techniques which could help better clinical decisions and treatment planning.

  • Clinical challenges and needs: What do clinicians need to monitor inflammatory/resolution status in patients for clinical decisions?
  • State-of-the-art imaging technologies: What are the in vivo imaging technologies currently available for monitoring inflammation/resolution?
  • Cross-validation: What are the opportunities for intersecting imaging and fluid-based inflammatory/resolution biomarkers?
  • Human applications: How can imaging inflammation capabilities help our understanding in predicting disease onset and progression in humans?


Multiple diseases and imaging approaches will be discussed.


Meeting Agenda


Day 1, June 10, 2019

7:45-8:30am Registration

8:30-8:40 am Welcome and Introduction

8:40-9:10 am Opening Keynotes

Novel pro-resolving mediators in resolution of inflammation and tissue regeneration Charles Serhan, Ph.D., DSc, Brigham and Women’s Hospital

9:10-10:00 am Clinical Challenges and Needs (I) Moderator: Johanna Dwyer, NIH ODS

9:10-9:35 Clinical challenges in the management of patients receiving immune checkpoint blockade for cancer Michael Postow, MD, Memorial Sloan Kettering Cancer Center

9:35-10:00 The dietary inflammatory index (DII) as a means and metaphor for describing the effect of diet on inflammation-related outcomes James R Hebert, ScD, The University of South Carolina

10:00-10:25 MRI-based biomarkers of fat, inflammation and fibrosis in liver Rohit Loomba, MD, University of California San Diego

10:25-10:40 am Coffee break

10:40-11:55 am Clinical Challenges and Needs (II) Moderator: Michelle Hamlet, NINR

10:40-11:05 Clinical evaluations to prevent post-thrombotic syndrome Fedor Lurie, MD Ph.D. JOBST Vascular Institute

11:05-11:30 Early detection of the progression of inflammatory, neuropathic pain Ru-Rong Ji, Ph.D. Duke University

11:30-11:55 Pseudoprogression in patients with cancer: regulatory and clinical development challenges Victoria Chiou, MD, FDA

11:55-12:55 pm Panel Discussion Moderator: Andrei Kindzelski, NHLBI

12:55-1:55 pm Lunch


1:55-2:55 pm State-of-the-art Imaging Capabilities (I) Moderator: Chiayeng Wang, NIDCR

1:55-2:20 Optical imaging of immunity Stefan Uderhardt, MD, NIAID

2:20-2:45 LED-based photoacoustic imaging for detecting joint inflammation Xueding Wang, Ph.D., University of Michigan

2:45-3:10 Molecular imaging sensors for biomarkers of inflammation Alexei Bogdanov, Ph.D., the University of Massachusetts at Worcester

3:10-3:25 pm Coffee break

3:25-4:25 pm State-of-the-art Imaging Capabilities (II) Moderator: Shang-Yi Tsai, NIDA

3:25-3:50 Label-free metabolic tissue imaging and its potential to assess inflammatory responses Irene Georgakoudi, Ph.D. Tufts University

3:50-4:15 Vitamin C-based hyperpolarized MRI to integrate oxidative stress in vivo Kayvan R. Keshari, Ph.D. Memorial Sloan Kettering Cancer Center

4:15-4:40 Comparative molecular imaging of cancer and inflammation in companion animals Amy Leblanc, DVM. NCI-CCR

4:40-5:40 pm Panel Discussion Moderators: Mercy Prabhudas & Merriline Vedamony, NIAID

5:40-5:45pm Wrap-up


Day 2, Jun 11, 2019

7:30-8:00 am Registration

8:00-8:15 am Goals and Objectives

8:15-9:55 am Cross Validations Moderator: Danielle Carrick, NCI

8:15-8:40 The critical role of imaging in the FNIH Biomarkers Consortium’s Inflammation and Immunity Portfolio Stephanie Cush, Ph.D. Foundation for National Institutes of Health

8:40-9:05 Imaging immune phenomena Martin G. Pomper, MD, Ph.D., Johns Hopkins University

9:05-9:30 Integration of imaging and biomarkers for the early detection of hepatocellular carcinoma Laura Beretta, Ph.D., University of Texas MD Anderson Cancer Center

9:30-9:55 Connecting the dots in atherosclerosis immunology by PET/MRI Zahi Fayad, Ph.D., Icahn School of Medicine at Mount Sinai

9:55-10:10 am Coffee Break

10:10-11:30 am Human Applications Moderator: George McKie, NEI

10:10-10:35 Integrated imaging modalities in understanding the progression of ALS and other neuro-inflammatory diseases Eva M. Ratai, Ph.D., Massachusetts General Hospital

10:35-11:00 Imaging of coronary inflammation to predict residual cardiovascular risk Milind Y. Desai, MD, Cleveland Clinic

11:00-11:25 Imaging pain: pinpointing the site of pain generation and inflammation using molecular imaging and PET/MRI Sandip Biswal, MD, Stanford University

11:25-12:25 pm Panel Discussion Moderator: Martin Pomper, JHU

12:25 -12:40 pm Wrap-up/Adjourn


DIRECTIONS

AIRPORTS/METRO/PARKING

Reagan National Airport (DCA) is the closest airport connected to the Washington Metro. Dulles International Airport (IAD) and Baltimore-Washington International Airport (BWI) are approximately 45 minutes from the meeting location.

The meeting location is near the Twinbrook Metro Station on the Red Line of the Washington Metro.

You can park at the garage behind 5635 Fishers Land which charges $9 per day (rate is subjected to change) and walk to the building of the event.

LODGING INFORMATION

We have reserved a room block at the EVEN Hotel Rockville for this workshop over the nights of June 9 and June 10, at a special rate of $209.00 plus tax for a single room. This hotel is about 0.8 miles (about a 17-min walk) from the meeting site. The hotel will provide shuttle service to the event site. The cut-off date is May 20, 2019. You can make your room reservation through one of the following:

  • Phone at 855.TRY.EVEN (855.879.3836) or 301.881.3836 for Reservations Department and refer Group Name NIH Imaging Inflammation Workshop

  • Online at NIH Imaging Inflammation Workshop for reservations.

CONTACT

For additional information about this workshop, please contact christina.liu@nih.gov.

NIH WebEx

This meeting will be live on NIH WebEx on both meeting dates.

IMPORTANT: You will need to register to view the VideoCast using the link below (in addition to registering to attend the workshop).

https://attendee.gotowebinar.com/register/5568159278689411330.

NOTE

Events listed below the "TAGS" are not associated with or endorsed by the National Institutes of Health

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NIAID Conference Center

5601 Fishers Lane, Rm 1D13

Rockville, MD 20852

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