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NIH Workshop on Imaging Inflammation and its Resolution in Health and Disea...

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NIAID Conference Center

5601 Fishers Lane, Rm 1D13

Rockville, MD 20852

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Chronic, unresolved inflammation has been implicated in promoting disease development. A comprehensive assessment of the inflammation and resolution states is essential to determine if an unresolved inflammation is on the path to cause more harm to the organ sites that are vulnerable to develop diseases. Currently, an individual’s immunological status is monitored through laboratory tests of a panel of established circulatory inflammatory biomarkers. These test results can then serve as a warning sign of an infection or inflammation somewhere in the body. If the numbers are above the clinically-defined threshold, additional laboratory procedures at a specific organ site may be prescribed. Unfortunately, the immunological readouts of the possible disease sites are based on histopathological analysis of tissue biopsies; these methods are invasive and lack spatial and temporal information. Although such invasive procedures may be acceptable to devastating diseases such as cancer, they can’t be used to monitor the impending disease, and evaluate intervention or treatment efficacy on the tissue we intend to save. Recent advances in medical imaging techniques are enabling assessment of organ sites with improved accuracy due to higher monitoring speed, sensitivity, and resolution. With the rapid developments of novel strategies in synthesizing molecular imaging probes in the past ten years, imaging capabilities can now dynamically measure biological (e.g., inflammatory) signatures in living animals, at the molecular, cellular, anatomical, functional and metabolic levels. All these in vivo methods can potentially be adapted and translated to become clinical tools for immunological readouts of vulnerable organ sites within an individual patient for a personalized interventional or treatment plan.

The goal of this 1.5-day workshop intends to bring together practicing physicians, clinical researchers, and imaging tool developers to identify clinical needs and opportunities and align research and development efforts toward in vivo imaging-based tools and techniques to monitor individual's inflammatory and resolution state at the organ levels for better clinical decisions and treatment planning. There are four topical areas of discussions.

(1) Clinical Challenges and Needs: What do clinicians need to monitor inflammatory/resolution status in patients for clinical decisions?

(2) State-of-the-art Imaging Technologies: What are the in vivo imaging technologies currently available for monitoring inflammation/resolution?

(3) Cross Validations: What are the opportunities for intersecting imaging and fluid-based inflammatory/resolution biomarkers?

(4) Human Applications: How can imaging inflammation capabilities help our understanding in predicting disease onset and progression in human?

Multiple panel discussions will provide opportunities for dialogues and alignment between the clinicians and image tool developers to facilitate image-based research effort toward meeting the clinical needs.


Meeting Agenda


Day 1, June 10, 2019

8:00-8:30am Registration

8:30-9:40 am Welcome and Introduction

8:40-9:10 am Opening Keynotes

Novel pro-resolving mediators in resolution of inflammation and tissue regeneration Charles Serhan, Ph.D., DSc, Brigham and Women’s Hospital

9:10-10:00 am Clinical Challenges and Needs (I) Moderator: Johanna Dwyer, NIH ODS

9:10-9:35 Clinical challenges in the management of patients receiving immunotherapy for cancer Michael Postow, MD, Memorial Sloan Kettering Cancer Center

9:35-10:00 The dietary inflammatory index (DII) as a predictor of metabolic syndrome and other conditions related to chronic, systemic inflammation James R Hebert, ScD, The University of South Carolina

10:00-10:25 MRI-based biomarkers of fat, inflammation and fibrosis in liver Rohit Loomba, MD, University of California San Diego

10:25-10:40 am Coffee break

10:40-11:55 am Clinical Challenges and Needs (II) Moderator: Michelle Hamlet, NINR

10:40-11:05 Clinical evaluations to prevent post-thrombotic syndrome Fedor Lurie, MD Ph.D. JOBST Vascular Institute

11:05-11:30 Early detection of the progression of inflammatory, neuropathic pain Ru-Rong Ji, Ph.D. Duke University

11:30-11:55 Pseudoprogression in patients with cancer: regulatory and clinical development challenges Victoria Chiou, MD, FDA

11:55-12:55 pm Panel Discussion Moderator: Andrei Kindzelski, NHLBI

12:55-1:55 pm Lunch


1:55-2:55 pm State-of-the-art Imaging Capabilities (I) Moderator: Chiayen Wang, NIDCR

1:55-2:20 Optical imaging of immunity Stefan Uderhardt, MD, NIAID

2:20-2:45 LED-based photoacoustic imaging for detecting joint inflammation Xueding Wang, Ph.D., University of Michigan

2:45-3:10 Molecular imaging sensors for inflammatory biomarkers Alexei Bogdanov, Ph.D., the University of Massachusetts at Worcester

3:10-3:25 pm Coffee break

3:25-4:25 pm State-of-the-art Imaging Capabilities (II) Moderator: Shang-Yi Tsai, NIDA

3:25-3:50 Label-free metabolic tissue imaging and its potential to assess inflammatory responses Irene Georgakoudi, Ph.D. Tufts University

3:50-4:15 Vitamin C-based hyperpolarized MRI to integrate oxidative stress in vivo Kayvan R. Keshari, Ph.D. Memorial Sloan Kettering Cancer Center

4:15-4:40 Comparative molecular imaging of cancer and inflammation in companion animals Amy Leblanc, DVM. NCI-CCR

4:40-5:40 pm Panel Discussion Moderators: Mercy Prabhudas & Merriline Vedamony, NIAID

5:40-5:45pm Wrap-up


Day 2, Jun 11, 2019

7:30-8:00 am Registration

8:00-8:15 am Goals and Objectives

8:15-9:55 am Cross Validations Moderator: Danielle Carrick, NCI

8:15-8:40 The critical role of imaging in the FNIH Biomarkers Consortium’s Inflammation and Immunity Portfolio Stephanie Cush, Ph.D. Foundation for National Institutes of Health

8:40-9:05 Imaging immune phenomena Martin G. Pomper, MD, Ph.D., Johns Hopkins University

9:05-9:30 Biomarkers of early detection and prevention of HCC in NASH Laura Beretta, Ph.D., University of Texas MD Anderson Cancer Center

9:30-9:55 Connecting the dots in atherosclerosis immunology by PET/MRI Zahi Fayad, Ph.D., Icahn School of Medicine at Mount Sinai

9:55-10:10 am Coffee Break

10:10-11:30 am Human Applications Moderator: George McKie, NEI

10:10-10:35 Integrated imaging modalities in understanding the progression of ALS Eva M. Ratai, Ph.D., Massachusetts General Hospital

10:35-11:00 Imaging of coronary inflammation to predict residual cardiovascular risk Milind Y. Desai, MD, Cleveland Clinic

11:00-11:25 Molecular and cellular imaging of inflammatory pain generators in human subjects Sandip Biswal, MD, Stanford University

11:25-12:25 pm Panel Discussion Moderator: Martin Pomper, JHU

12:25 -12:40 pm Wrap-up/Adjourn


DIRECTIONS

AIRPORTS/METRO/PARKING

Reagan National Airport (DCA) is the closest airport connected to the Washington Metro. Dulles International Airport (IAD) and Baltimore-Washington International Airport (BWI) are approximately 45 minutes from the meeting location.

The meeting location is near the Twinbrook Metro Station on the Red Line of the Washington Metro.

You can park at the garage behind 5635 Fishers Land which charges $9 per day (rate is subjected to change) and walk to the building of the event.

LODGING INFORMATION

We have reserved a room block at the EVEN Hotel Rockville for this workshop over the nights of June 9 and June 10, at a special rate of $209.00 plus tax for a single room. This hotel is about 0.8 miles (about a 17-min walk) from the meeting site. The hotel will provide shuttle service to the event site. The cut-off date is May 20, 2019. You can make your room reservation through one of the following:

  • Phone at 855.TRY.EVEN (855.879.3836) or 301.881.3836 for Reservations Department and refer Group Name NIH Imaging Inflammation Workshop

  • Online at NIH Imaging Inflammation Workshop for reservations.

CONTACT

For additional information about this workshop, please contact christina.liu@nih.gov.

NIH WebEx

This meeting will be live on NIH WebEx on both meeting dates. Please register to attend the VideoCast.

Link for Day 1: https://cbiit.webex.com/cbiit/onstage/g.php?MTID=e769aa3f749fab6e3f014bd20f6e7255f

Link for Day 2: https://cbiit.webex.com/cbiit/onstage/g.php?MTID=ee6097378a24fd8ce976cf50b1be3f1cd

Join by phone: 1-650-479-3207 Call-in toll number (US/Canada)


NOTE

Events listed below the "TAGS" are not associated with or endorsed by the National Institutes of Health

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NIAID Conference Center

5601 Fishers Lane, Rm 1D13

Rockville, MD 20852

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