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NIDA Genetics Consortium Meeting

Amy Lossie (NIDA)

Saturday, June 16, 2018 from 8:30 AM to 5:30 PM (PDT)

NIDA Genetics Consortium Meeting

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NIDA Genetics Meeting

Coordinating Efforts Between Human and Animal Opioid Studies

University of California San Diego

Medical Education and Telemedicine Building

June 16th, 2018

9:00 AM to 5:30 PM

 

8:30    Registration

8:45    Welcome

            Amy C. Lossie, PhD and Jonathan Pollock, PhD

9:00 to 10:30 Panel I: Phenotype Harmonization

9:00    Laura Bierut, MD

            State of the science for human studies – Triumphs, limitations, opportunities

9:05    Olivier George, PhD

            Phenotypes to examine in animal models, what can be measured? A LOT!

9:10    Dan Larach, MD

            Analysis of Persistent Opioid Use in a Surgical Patient Cohort

9:15    Sesh Mudumbai, MD

Phenotypes and the VA Million Veteran Program (MVP)

9:20    Panel Discussion

9:45    Breakout Session I Phenotype Harmonization

Notetaker: Chelsie Benca-Bachman, PhD 

10:30  Break 

10:45  to 12:00         Panel II: Translating Genetic Findings Between Species

10:45  Elissa Chesler, PhD

            Characterizing regulatory variants in humans and animals using GeneWeaver

10:50  Gary Peltz, PhD

             Using animal studies to inform human genetic findings

10:55  Abraham Palmer, PhD

            Capitalizing on the genetics of human, mouse and rat studies

11:00  Panel Discussion

11:15  Breakout Session II Genotype Harmonization

Notetaker: Hannah Cates, PhD

12:00 to 1:15             Lunch (nearby restaurants - http://universitycenters.ucsd.edu/eat.php)

1:15 to 2:00   Updates from Large Consortia

1:15    Updates from the Psychiatric Genetics Consortium

            Howard Edenberg, PhD

1:30    Updates from the NGC Opioid Meta-analysis

            Eric Johnson, PhD

1:45    Updates from the ABCD Study

            Susan Tapert, PhD

2:00    Updates from the Externalizing Phenotypes Consortium

            Danielle Dick, PhD

Notetaker: Giordano de Guglielmo, PhD

2:15 to 3:15               Panel III: Making Sense of Allelic Variation

2:15    Vanessa Troiani, PhD

Capitalizing on Large Health Systems to understand prescription opioid addiction

2:20    Tamara Richards, PhD

            Implications of background genetics on GWAS studies

2:25    Panel Discussion

2:40    Breakout Session III: Validating GWAS Hits

Notetaker: Marsida Kallupi, PhD

3:15    Break

3:30 to 4:30               Panel IV: Pathway Conservation

3:30    Robert Hitzemann, PhD

Accounting for differences in genetic findings for alcohol in humans and rodents

3:35    Huda Akil, PhD

            Integrating genes and regulatory pathways

3:40    Laura Saba, PhD

            Using transcriptomic networks for integrative analyses

3:45    Panel Discussion

4:00    Breakout Session IV: Pathway Conservation

Notetaker: April Shu, PhD  

4:35 to 5:30   Breakout Session Reports

4:35    Breakout Session I

4:45    Breakout Session II

5:55    Breakout Session III

5:05    Breakout Session IV

5:15    Wrap up

Notetaker: Sarah Schoenrock, PhD

5:30    Adjourn

Questions for Breakout Sessions

Breakout Session I: Phenotype Harmonization

  • What can we glean from studies today?
  • Where do we want to be in five years?
  • What are some strategies for reaching this goal?
  • What should NIDA’s priorities be in this area? What are the gaps and challenges (beyond funding)?

Questions to Ponder:

  • What phenotypes in humans and animal models should be prioritized? Why?
  • What methods can be used to correlate phenotypes among human and animal studies?
  • What is needed in future studies to harmonize opioid genetics cohorts (and other large SUD cohorts?)
  • What are best practices for incorporating large cohort studies? What are the barriers? How can these be removed?

Breakout Session II Translating Genetic Findings Between Species

  • What can we glean from studies today?
  • Where do we want to be in five years?
  • What are some strategies for reaching this goal?
  • What should NIDA’s priorities be in this area? What are the gaps and challenges (beyond funding)?

Questions to Ponder:

  • What are some methods to translate between species?
  • What methods need to be developed to optimize translation?
  • How can animals best be used to confirm human studies?
  • What questions can be uniquely addressed in animals? How can this be useful to human studies?

Breakout Session III: Making Sense of Allelic Variation

  • What can we glean from studies today?
  • Where do we want to be in five years?
  • What are some strategies for reaching this goal?
  • What should NIDA’s priorities be in this area? What are the gaps and challenges (beyond funding)?

Questions to Ponder:

  • How can we assess functionality of allelic variation between species?
  • What methods need to be developed to optimize functional assessment of homologues? Orthologues? Gene Families?
  • How can animals best be used to confirm human studies?
  • What questions can be uniquely addressed in animals? How can this be useful to human studies?

Breakout Session IV: Pathway Conservation

  • What can we glean from studies today?
  • Where do we want to be in five years?
  • What are some strategies for reaching this goal?
  • What should NIDA’s priorities be in this area? What are the gaps and challenges (beyond funding)?

Questions to Ponder:

  • How can we assess gene networks and pathways between species?
  • What are strategies to integrate genomic, epigenomic and other functional data?
  • How can animals best be used to confirm human studies?
  • What questions can be uniquely addressed in animals? How can this be useful to human studies?

Breakout Session Facilitators:

Chelsie Benca-Bachman, PhD, Postdoctoral Fellow, Emory University

Hannah Cates, PhD, Postdoctoral Research Associate, Mount Sinai School of Medicine

Giordano de Guglielmo, PhD, Senior Research Associate, The Scripps Research Institute

Marsida Kallupi, PhD, Senior Research Associate, The Scripps Research Institute

Sarah Schoenrock, PhD, Postdoctoral Research Associate, UNC ­­– Chapel Hill

April Shu, PhD, Postdoctoral Research Associate, Johns Hopkins University

Amy C. Lossie, PhD, Program Officer, GEDN, NIDA

Jonathan D. Pollock, PhD, Branch Chief, GEDN, NIDA


Have questions about NIDA Genetics Consortium Meeting? Contact Amy Lossie (NIDA)

When & Where


University of California San Diego (UCSD)
Telemedicine Building
Directions - http://telemedicine.ucsd.edu/index.cfm?p=directions
La Jolla, CA 92093

Saturday, June 16, 2018 from 8:30 AM to 5:30 PM (PDT)


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