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Natural Products and Pain: The search for novel non-opioid analgesics

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NIH Campus Natcher Bulding 45 Balcony B

45 Center Drive

Bethesda, MD 20892

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The goal of the workshop is to facilitate the identification of novel non-opioid natural products with efficacious and non-addictive analgesic properties. The workshop will also discuss research barriers for the study of such natural products for pain treatment and management. The discussion will focus on how to identify promising leads based on traditional medicine; how to discover and identify active natural products; and how to characterize the mechanisms through which they act. The talks will be organized around promising known non-opioid classes of natural products from various sources and will walk through their discovery and challenges that have been encountered in their development. The workshop is targeted to researchers engaged in basic and mechanistic research in the fields of natural products and/or pain signaling. We hope that through this workshop we will provide novel and important contributions to the goal of finding solutions to the current pain and opioid crisis.

Registration is free, and open to the first 80 online registrants for in-person attendance.

(Draft Workshop Agenda)

Natural Products and Pain: The search for novel non-opioid analgesics

Workshop Chair: David Julius (UCSF)

NIH Workshop Planning Committee:

NCCIH: Wen Chen; Craig Hopp; Dee Gamliel

NINDS: Michael Oshinsky

NCATS: Philip Sanderson, Samantha Jonson

Date: February 6, 2018 Wednesday

Location: NIH Campus, Natcher Conference Center

8:30-8:40 a.m. Opening Remarks: NIH IC Directors

8:40-10:10 a.m. Session One: Overview -- How to find the needles in a haystack?

(Moderator: Craig Hopp)

  • Cassandra Quave, Emory University: How to find natural remedies for pain management?
  • David Julius, UCSF: Challenges of finding the chemicals from natural organisms
  • Justin DuBois, Stanford University: Challenges of mimicking the natural chemicals for their therapeutic potentials
  • Panel Discussions

10:10 a.m.-10:25 p.m. BREAK

10:25 a.m.-11:55 a.m. Session Two: The science of animal-derived natural products

(Moderator: Michael Oshinsky)

  • Mande Holford, Hunter College: Snail venom, conotoxin, and pain
  • Les Miranda, Amgen: Peptide toxins and pain
  • Ru-Rong Ji, Duke University: Fish oil and pain
  • Panel Discussions

11:55 p.m.-12:55 p.m. LUNCH BREAK

12:55 p.m.- 2:55 p.m. Session Three: The science of plant-based natural products and supplements (Moderator: Philip Sanderson)

  • Mike Iadarola, NIDCR: Cactus-like plant, Resiniferatoxin, and pain
  • Laura Bohn, Scripps Institute: Plant, Conolidine, and pain
  • Yan Xu, University of Pittsburgh: Cannabinoids and pain
  • Donna Hammond, University of Iowa: NAD+ and pain
  • Panel Discussions

2:55 p.m.- 3:10 p.m. BREAK

3:10 p.m.- 4:40 p.m. Session Four: The science of bacteria-derived natural products

(Moderator: Wen Chen)

  • Philippe Picaut, Ipsen Bioscience: Botulinum toxin and pain
  • Isaac Chiu, Harvard University: Microbiome, gut, and pain
  • David Klumpp, Northwestern University: Probiotics and pain
  • Panel Discussions

4:40-5:30 p.m. Concluding Session: Discussions and Future Directions

  • Chaired by David Julius

FAQs

Campus Access Map with Perimeter Security

NIH Gateway Center at Metro: Employees and Visitors

  • 6 am to 10 pm, Monday through Friday
  • Closed on Weekends and Observed Holidays
  • After 10 pm on weekdays, all day weekends and holidays, pedestrian visitors should enter campus via the Commercial Vehicle Inspection Facility (CVIF) - Building 67 (on Rockville Pike between North Drive and Wilson Drive)

What are my transportation/parking options for getting to and from the event?

Main Visitor Entrance: NIH Gateway Drive

Gateway Center - Building 66 (for pedestrians entering campus)
  • Open Monday – Friday, 6am – 10pm

  • Closed on Weekends and Observed Holidays

  • After 10pm on weekdays, all day weekends and holidays, pedestrian visitors should enter campus via the Commercial Vehicle Inspection Facility (CVIF) - Building 67 (on Rockville Pike between North Drive and Wilson Drive)

Gateway Inspection Station - Building 66A (for vehicles entering campus)

  • Monday-Friday: 5am - 10pm

    Weekends and After Hours:
    Closed

    After 10pm on weekdays, all day weekends and holidays, visitors in vehicles should enter campus via the Commercial Vehicle Inspection Facility (CVIF) - Building 67 (on Rockville Pike between North Drive and Wilson Drive)

  • After inspection, vehicles enter campus at Center Drive
  • Roadway at Center Drive is for entering campus only; visitors exiting campus may exit from other open locations. To see a list of exits, please visit the employee map.
  • All vehicles and their contents will be inspected upon entering the campus.

How can I contact the organizer with any questions?

dee.gamliel@nih.gov

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NIH Campus Natcher Bulding 45 Balcony B

45 Center Drive

Bethesda, MD 20892

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