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Mitigating risk of off-target effects when using CRISPR [SS1-0318]

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ACHUCARRO BASQUE CENTER FOR NEUROSCIENCE

Leioa

Spain

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Mitigating risk of off-target effects when using CRISPR genome editing


During this presentation you will learn about:

• Optimized strategies for CRISPR-Cas9 mediated genome editing, with emphasis on methods commonly used for delivery of guide RNAs and Cas9 as a ribonucleoprotein complex

• The risk of off-target effects (OTEs): how to find and measure the frequency of off-target effects (OTEs) including discussion of bioinformatic screening for OTEs and methods for unbiased CRISPR OTE detection

• Recent developments in CRISPR research, including a novel mutant Cas9 protein that has been evolved to reduce off-target gene editing while maintaining on-target potency


Speaker: Mirko Vanetti, PhD

European Application Manager - Functional Genomics

Date and Time

Location

ACHUCARRO BASQUE CENTER FOR NEUROSCIENCE

Leioa

Spain

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