The Johns Hopkins Institute for Clinical and Translational Research (ICTR) is sponsoring a lunch and learn lecture series to disseminate new methodologies related to clinical trials.

The initial lecture, “Improving Precision by Adjusting for Prognostic Baseline Variables in Randomized Trials, Without Regression Model Assumptions,” will be Thursday, May 25 from 11:30 a.m.- 1:00 p.m. at Tilghman Auditorium in the Miller Research Building. Speaker Michael Rosenblum, PhD, associate professor of Biostatistics at the Johns Hopkins Bloomberg School of Public Health, will share how his research develops improved methods for the design and analysis of randomized trials.

He will discuss:

• The potential to improve precision and reduce sample size by appropriately adjusting for baseline variables that are correlated with the primary outcome.
• Practical guidance on how to avoid uninterpretable estimates, while retaining the advantages of covariate adjustment.
• Using simple (but less well-known) standardization methods from the recent statistics literature.
• Software in R and Stata for implementing these methods.

Lunch will be provided.

For more information, contact Daniel Scharfstein at dscharf@jhu.edu