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Improving CRISPR Genome Editing using High-Fidelity Cas9 protein and chemic...

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St. Michael's Hospital

2nd Floor Auditorium

Toronto, Ontario

Canada

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We will review how IDT developed the most potent set of genome editing tools on the market by combining the precision of chemically synthesized crRNA and tracrRNA with a high performance Cas9 protein. The Alt-R CRISPR system offers powerful, on-target editing; reduced off-target effects compared to traditional systems; is non-toxic; and easy to deliver into a wide array of cells by lipofection or electroporation. This presentation will review applications, including gene disruption and HDR. In addition, we will present a novel high-fidelity Cas9 mutant that has been optimized to further reduce off-target gene editing while maintaining on-target potency.

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Date and Time

Location

St. Michael's Hospital

2nd Floor Auditorium

Toronto, Ontario

Canada

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