The human race, like all macrobiological life, evolved in a sea of microbes. There was no way to keep the bacterial and archaeal hoards at bay, so instead life evolved mechanisms to live with these invaders. The immune system was refined over millions of years to control our interaction with the microbial world, and even to use it as a mechanism of defense, food processing, and vitamin production. The immune system and the microbiome have shaped each other in extraordinarily elaborate and intricate ways. Here we will discuss some of the recent evidence highlighting these mechanisms of interaction. We will also discuss how the last 150 years, have started to disturb the delicate balance of the immune-microbe equilibrium. As our natural ecosystem has been restricted to the built environment, especially in the developed world, where an average of 90% of our lives take place indoors, our exposure to the microbial world has been corrupted. Modern buildings are equipped with surfaces and environmental systems designed to reduce the potential for microbial life to flourish. This fundamental shift in our lifestyle is likely impacting the development and function of our immune systems in ways that we are only beginning to understand.
We are now starting to experiment with adding bacteria back in to our overly sterile existence. In one such study we were able to significantly reduce cows milk allergy in infants through active manipulation of the gastrointestinal microbiota. Exploring the dynamic interactions that humans share with our indoor space, and mapping the interactions that lead to alterations in our own microbiome will be extremely important for determining the best way to augment our environment with a beneficial microbiome.
Jack A. Gilbert, Ph.D., is the Director of the Microbiome Center and a Professor of Surgery at the University of Chicago. He is also Group Leader for Microbial Ecology at Argonne National Laboratory, Associate Director of the Institute of Genomic and Systems Biology, Research Associate at the Field Museum of Natural History, and Senior Scientist at the Marine Biological Laboratory. Dr. Gilbert uses molecular analysis to test fundamental hypotheses in microbial ecology. He has authored more than 200 peer reviewed publications and book chapters on metagenomics and approaches to ecosystem ecology. He is currently working on generating observational and mechanistic models of microbial communities in natural, urban, built and human ecosystems. He is on the advisory board of the Genomic Standards Consortium (www.gensc.org), and is the founding Editor in Chief of mSystems journal. In 2014 he was recognized on Crain’s Business Chicago’s 40 Under 40 List, and in 2015 he was listed as one of the 50 most influential scientists by Business Insider, and in the Brilliant Ten by Popular Scientist.
Reception at 5:30, program at 6:00 p.m. The British International School is located near the North/Clybourn CTA Red Line stop, and off the North Avenue and Halsted Street busses. Parking is also available adjacent to the school for a discounted rate of $6 for three hours or less with validation at the front desk of the school.
This program will be presented in partnership with the British International School of Chicago, Lincoln Park. the school is a private school for students ages 2 – 11 years old offering a values-based, academically rigorous education through social, global, and innovative hands-on learning experiences -- all under the roof of a newly renovated, 75,000 square foot, state-of-the-art, five-story campus. It is part of a network of 42 schools across the globe, and its students and faculty represent an international community of thinkers focused on inquiry based learning and developing 21st century skills. www.bischicaglp.org