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Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions

WORKSHOP: March 28-29, Washington, DC

The National Academies of Sciences, Engineering, and Medicine will be holding a workshop on MARCH 28-29, 2019, in Washington, DC, on evidence integration, which is a summary step of the systematic review in human health assessments conducted by the US Environmental Protection Agency (EPA). Topic areas include:

  • Lessons learned from the Evidence integration Colloquium that was held in Lisbon, Portugal in October 2017,

  • Best Practices in Evidence Integration,

  • Approaches for Using Mechanistic Data to Integrate Evidence from Animal and Human Studies,

  • Case Studies of Systematic Review-Enabled Evidence Integration, and

  • Practical Approaches to Expedited Evidence Integration.

Evidence integration, also referred to as weight-of-evidence evaluation, is a summary step of the systematic review in human health assessments conducted by EPA’s National Center for Environmental Assessment. During this step, conclusions are drawn from each line of evidence that is relevant to the predefined PECO criteria. (PECO refers to population, exposure, comparators, and outcomes.) Evidence integration generally involves subjecting the relevant evidence to a causal analysis, which can be conducted using both qualitative and quantitative approaches. This is a structured process by which conclusions are drawn regarding the potential health effects in exposed humans, incorporating judgments about the strength of the human and animal evidence (both within and across lines of evidence) as well as information from mechanistic data necessary to answer key questions.

The overall objective of the workshop is to explore strategies for addressing challenges that arise for EPA during evidence integration in chemical assessments, with a primary focus on the use of mechanistic data. Poster sessions will accompany the workshop to address topics that are relevant to the workshop session topics.

Poster Session

Poster presentations considered for acceptance will focus on at least one of these topics, with a focus on the use of mechanistic data:

  • Best Practices in Evidence Integration,

  • Approaches for Using Mechanistic Data to Integrate Evidence from Animal and Human Studies,

  • Case Studies of Systematic Review-Enabled Evidence Integration, and

  • Practical Approaches to Expedited Evidence Integration.

Submission and Selection Process

  • Deadline for submission is February 1, 2019.

  • Poster abstract submission is open to the public.

  • Abstracts will be reviewed and selected by the workshop organizing committee.

  • All travel costs are the responsibility of the presenters.

Submit a Poster Application Here


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