£853.39 – £1,333.09

European Fiber-Optic Advanced Training Course 2019

Event Information

Share this event

Date and Time

Location

Location

Lingfield Park Marriott Hotel & Country Club

Racecourse Road

Lingfield

RH7 6PQ

United Kingdom

View Map

Event description
Advanced Fiber Optic Training - Learn more about how to use your Pion Rainbow

About this Event

Join us for our Advanced Fiber Optic Training.

Note: Please bring your own laptop for the training course. The AuPRO software version 5.5 will be installed for the group discussions.

AGENDA

Thursday, June 20th

8:15 – 8:45 Attendee Arrival

8:45 – 9:00 Introduction to Pion and personnel

9:00 – 10:15 Method Development Part 1: Getting started with the technology and basic considerations

• Introduction to Pion Fiber Optic instruments

• Principles and challenges of in situ concentration measurements

• Pathlength selections

• Generating good standard curve, “Blue Standards”

• Baseline correction algorithms

• 2nd derivative spectroscopy

• Calculation settings

• Sample Blank

10:15– 10:40 Break

10:40 – 11:25 Method Development Part 2: Advanced considerations

• Spectral shape analysis

• Blank and Reference Channel

• Can standard curve be prepared in different media

• Supersaturation considerations

• Media conversion experiments

11:25 – 12:10 Interactive Group Discussion #1: Fiber Optic Method Development. Working with changing background and molar absorptivity

12:10 – 1:10 Lunch (provided)

1:10 – 1:40 User Case Study #1 (TBD)

1:40 – 2:10 Zero intercept Method: Principles and Applications of ZIM

• Dual-component dissolution

• Monitoring for spectral consistency

• Solubility of nanoparticles

• Amorphous solubility vs. new phase formation

2:10 – 2:40 Group Discussion #2: Practical aspects of ZIM method implementation

2:40 – 3:00 Break

3:00 – 3:30 Advanced Tools: Dissolution Curve Analysis

• Relations between dissolution, solubility, particle size and hydrodynamics

• Intrinsic dissolution rate (IDR) measurements

• Predicting disk IDR from powder dissolution experiments

• Effective particle size estimation from the powder dissolution profile, prediction of Dissolution Number

3:30 – 4:00 Group Discussion #3: Dissolution Curve Analysis hands on practice

4:00 – 4:30 Behind the scenes tour at Lingfield Park (included with registration)

5:00 – 8:00 3-Course Group Dinner (included with registration)

Friday, June 21st

8:15 – 8:45 Attendee Arrival

8:45 – 9:30 Tools for understanding drug behavior – overview of Pion technology

9:30 – 10:00 DissoPRO software: streamlining fiber optic operations while meeting GMP requirements

• Relations between AuPRO and DissoPRO software packages

• Streamlining the workflow—saving fiber optic methods

• Flexibility of suitability criteria

• Secure data location, audit trails, user roles

10:00 – 10:45 Towards in vivo predictive dissolution – flux measurements

• Understanding the principles and driving forces of the flux

• Flux considerations

• Calculation and interpretation of flux data

• In vivo predictions using flux data

10:45 – 11:05 Break

11:05 – 11:35 User Case Study #2 (TBD)

11:35 – 12:35 Flux measurements: Analytical work behind the scene

• Detecting artifacts

• Membrane-excipient compatibility

• Ensuring membrane integrity

• Dual component flux

• Potential limitation of the flux measurement

12:35 – 1:35 Lunch (provided)

1:35 – 2:15 Group Discussion #4 Data Review and Basic Troubleshooting

2:15 – 3:00 Introduction to AuPRO Version 6: Recent Advances in Pion

• Dealing with more than 2 components—multicomponent regression analysis

• Scatter modelling—can we estimate particle size from the shape of baseline?

• Creating Reports

• Standards for nanoparticles and colloids

• Automating flux calculations

3:00 – 3:30 Q&A and Roundtable

CLOSE

Share with friends

Date and Time

Location

Lingfield Park Marriott Hotel & Country Club

Racecourse Road

Lingfield

RH7 6PQ

United Kingdom

View Map

Save This Event

Event Saved