EBTC Webinar: Mechanistic Evidence Pre Meeting (GRADE)

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Please access the webinar here: http://fhsmediasiteevp.mcmaster.ca/Mediasite/Play/7fe300d2c81d427ab915adb28c2ea8881d

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Sales Have Ended

Registrations are closed
Please access the webinar here: http://fhsmediasiteevp.mcmaster.ca/Mediasite/Play/7fe300d2c81d427ab915adb28c2ea8881d
Event description
Application of evidence-based methods to construct mechanistic frameworks for the development and use of non-animal toxicity tests

About this Event

Date: June 12, 2019

This is an online event and will start on June 12th at 9 am EST.

Please access the webinar here.

Abstract:

Systematic evidence synthesis methods and adverse outcome pathways are two relatively recent arrivals in the toxicologist's toolbox, which promise to bring toxicological research into the 21st Century.

The goal of this workshop is to explore, via discussion of four related themes, how systematic review methods and AOP concepts can be combined to develop and use non-animal test methods for predicting the toxicity of chemical substances in an evidence-based manner.

1. How do we distinguish high quality in vitro studies from low quality ones?

2. What does a systematic approach to AOP development look like?

3. How does one distinguish spurious AOPs from plausible ones?

4. How can one use AOP information to develop non-animal toxicity assays?

9:00 - Introduction (EBTC, GRADE - Katya Tsaioun, Holger Schünneman)

9:15 am - Keynote talks (20 minutes: 15 min. presentation + 5 min. clarifying questions):

1. Certainty in AOPs and AOP-based alternatives - Holger Schünemann, Chair and Professor, Department of Health Research Methods, Evidence, and Impact, Director, Cochrane Canada and McMaster GRADE Centre

2. Certainty in modelled data - Jan Brozek, McMaster University

3. Systematic maps and literature-driven AOP development- Michelle Angrish, US EPA, IRIS

10.15-10.45 am coffee break

4. Risk of bias appraisal of in vitro studies - Andrew Rooney, NIEHS, National Toxicology Program, OHAT

5. Using AOPs to develop non-animal alternatives and IATAs - Patience Browne, OECD

11.25 - 11.50 General discussion plenary talks

If you have any questions please contact Camila Januario cjanuar1@jhu.edu

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