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EBTC Mechanistic Evidence Pre Meeting (GRADE)

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McMaster University

1280 Main St. W.

Room HSC 1A1

Hamilton, ON L8S 4K1

Canada

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Application of evidence-based methods to construct mechanistic frameworks for the development and use of non-animal toxicity tests

About this Event

Full title: Application of evidence-based methods to construct mechanistic frameworks for the development and use of non-animal toxicity tests.

Date: June 12, 2019

Place: McMaster University, Hamilton, Ontario, Canada

IMPORTANT - READ THIS FIRST: Registration for this meeting is free and open to everyone, but does not guarantee participation. Due to limited seating and narrow scope of the workshop, the organizing committee will have to make the final decision based on the background of attendees. Please do not make any travel arrangements until you get an official email confirming your attendance.

Abstract:

Systematic evidence synthesis methods and adverse outcome pathways are two relatively recent arrivals in the toxicologist's toolbox, which promise to bring toxicological research into the 21st Century.

The goal of this workshop is to explore, via discussion of four related themes, how systematic review methods and AOP concepts can be combined to develop and use non-animal test methods for predicting the toxicity of chemical substances in an evidence-based manner.

1. How do we distinguish high quality in vitro studies from low quality ones?

2. What does a systematic approach to AOP development look like?

3. How does one distinguish spurious AOPs from plausible ones?

4. How can one use AOP information to develop non-animal toxicity assays?

9:00 - Introduction (EBTC, GRADE - Katya Tsaioun, Holger Schünneman)

9:15 am - Keynote talks (20 minutes: 15 min. presentation + 5 min. clarifying questions):

1. Certainty in AOPs and AOP-based alternatives - Holger Schünemann, Chair and Professor, Department of Health Research Methods, Evidence, and Impact, Director, Cochrane Canada and McMaster GRADE Centre

2. Certainty in modelled data - Jan Brozek, McMaster University

3. Systematic maps and literature-driven AOP development- Michelle Angrish, US EPA, IRIS

10.15-10.45 am coffee break

4. Risk of bias appraisal of in vitro studies - Andrew Rooney, NIEHS, National Toxicology Program, OHAT

5. Using AOPs to develop non-animal alternatives and IATAs - Patience Browne, OECD

11.25 - 11.50 General discussion plenary talks

11.50-12.00 Explanation break-out sessions

12.00 - 1 pm LUNCH

Afternoon: Break-out sessions (2 hours):

1.Quality appraisal of individual in vitro studies (RoB domains, impact of role within risk assessment etc) - Moderators: Andrew Rooney, NIEHS / Elisa Aiassa, EFSA / Rapporteur - Daniele Wikoff

2.Systematic maps and literature-driven AOP development- Moderators: Michelle Angrish, US EPA/Steve Edwards, RTI /Rapporteur - Paul Whaley

3.Certainty in AOPs and AOP-based alternatives - Rebecca Morgan GRADE-McMaster University/ Ingrid Druwe, OECD/ Rapporteur - Sebastian Hoffmann

4.Using AOPs to develop alternatives and IATAs for guidelines development - Patience Browne, OECD / Rapporteur - Katya Tsaioun, EBTC

Late afternoon:

3 pm Tea break

3.15 pm - 4.00 pm Report from the break-out groups (Short presentations of the main conclusions per break-out as well as the main challenges identified)

4.00 pm - 4.15 pm General discussion of potential approaches to tackle the challenges identified

4.15 - 5.15 pm Translation of general discussion into concrete actions (Which topics can/need to be addressed? Which examples/case studies would be useful? Who is willing to lead or participate in a work group to take on a certain topic? What would be the next occasion to meet?)

5.15 - 5.30 pm Closure

The meeting will happen at the McMaster Health Sciences Center Room HSC 1A1 which is located at 1280 Main St West, Hamilton, ON L8S 4K1

Breakfast and lunch will be served. If you have any dietary restrictions please contact cjanuar1@jhu.edu.

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Date and Time

Location

McMaster University

1280 Main St. W.

Room HSC 1A1

Hamilton, ON L8S 4K1

Canada

View Map

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