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Drug Development II: Molecular Signaling in the Development and Discovery..

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Translational Research Building (TRB) Room 819

227 east 30th street

8th Floor

New York, NY 10016

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MOLECULAR SIGNALING IN THE DEVELOPMENT AND DISCOVERY OF THERAPEUTICS

No prerequisites required. Limit to 10 postdocs. Only for NYU School of Medicine

Drug Development II syllabus

Course Description

The cumulative cost of developing a new, “successful” drug is now well over a billion dollars, and the reward of improved health and quality of life is priceless. The major contributing cost to drug development is the number of failures that occur for each success. It has become clear that understanding the molecular signaling pathways that either cause or modify disease processes are key to identifying drug targets with high efficacy and low toxicity. The objective of the course is to develop entity specific paradigms that can help predict successful drug development trajectories. Experts in their respective fields will discuss disease specific signaling pathways with the goal of
identifying critical steps that could be targeted by drug therapy. Our highlighted public health disease is diabetes, arguably one of the most significant determinants of public health and a leading cause of mortality and morbidity in the US. In addition to diabetes drugs, we will discuss other drugs with challenging development paths that turned out to be successful therapies, and by contrast, we will discuss other drugs that failed in the late stages, some after reaching the market. By understanding these paths and failures, future researchers will be able to predict, design, and anticipate success in drug discovery and development, thus bridging the gap between healthcare need and return. Furthermore, this course will expose students to new technologies (hardware and software), developing receptor and pathway networks, prediction models, and challenges with designing animal models and clinical trials. By the end of the course, students will be capable of launching their own drug development project from target selection through experimental testing.


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Translational Research Building (TRB) Room 819

227 east 30th street

8th Floor

New York, NY 10016

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