Disease Modification in Sickle Cell Disease: Mechanisms, Advances, and Clin...

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Hilton Orlando

6001 Destination Parkway

Orlando Ballroom I; Lower Lobby Level

Orlando, Florida 32819

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Event description


This program is intended for 61st ASH Annual Meeting and Exposition attendees only.

Activity Chair

Gregory J. Kato, MD
Professor of Medicine and Clinical and Translational Science
University of Pittsburgh School of Medicine
Pittsburgh, PA


Laura M. De Castro, MD, MHSc
Associate Professor of Medicine
Department of Medicine, Division of Hematology and Oncology
University of Pittsburgh Medical Center
Pittsburgh, PA

Lakshmanan Krishnamurti, MD
Professor of Pediatrics, Emory University
Director of Atlanta Bone Marrow Transplantation Program/ Hematology, Oncology, BMT, Childrens Healthcare, Emory University
Atlanta, GA

Punam Malik, MD
Director, Cincinnati Comprehensive Sickle Cell Center
Director, Translational Core Laboratory
Marjory J. Johnson Chair, Gene and Cell Therapy
Professor, UC Department of Pediatrics
Cincinnati's Children
Cincinnati, OH


Join Dr. Gregory J. Kato and colleagues for a CME breakfast symposium on the underlying mechanisms of currently available or late-stage therapies for sickle cell disease (SCD) that may be disease modifying. Faculty will discuss the latest clinical evidence for new or emerging disease-modifying options, as well as the implications of these therapeutic advances for the treatment of patients with SCD.


7:00 AM
Registration and Breakfast
Gregory J. Kato, MD

7:30 AM
Introduction and Pretest

7:35 AM
A Closer Look at Disease Modification in Sickle Cell Disease
Gregory J. Kato, MD

7:50 AM
Advances in Disease Modification in SCD – A Look at the Risk and Benefits

  • Bone Marrow Transplant
    Lakshmanan Krishnamurti, MD

  • Hydroxyurea
    Laura De Castro, MD, MHSc

  • Chronic Transfusion
    Laura De Castro, MD, MHSc

8:25 AM
Emerging Methods for SCD Modification

  • Gene Therapy
    Punam Malik, MD

  • Inhibiting Polymerization
    Gregory J. Kato, MD

8:55 AM
Panel Discussion – What is the Future of Disease-Modifying Options in Sickle Cell Disease?
Moderated by Gregory J. Kato, MD

9:20 AM
Posttest and Question & Answer

9:30 AM

Learning Objectives

Upon successful completion of this activity, participants should be better able to:

  • Examine the mechanisms underlying available or late-stage treatments for patients with SCD that work upstream of HbS polymerization and may be disease-modifying.

  • Summarize the benefits and limitations of conventional disease-modifying options for patients with SCD.

  • Evaluate the latest clinical evidence regarding new or emerging disease-modifying options for patients with SCD and the implications for patients.

  • Select treatment for patients with SCD based on the latest clinical evidence.

Target Audience

The intended audience for this activity is hematologists and other health care professionals involved in the management of patients with SCD.

This continuing medical education activity is provided by Vindico Medical Education.

This activity is supported by an educational grant from Global Blood Therapeutics.

This activity is preceding the 61st ASH Annual Meeting and Exposition.

Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Vindico Medical Education designates this live activity for a maximum of 2.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all planners, teachers, and authors involved in the development of CME content are required to disclose to the accredited provider their relevant financial relationships. Relevant financial relationships will be disclosed to the activity audience.

Faculty, topics, program schedule, and credit hours are subject to change. Audiotaping or videotaping is prohibited without written permission from the program committee.

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Hilton Orlando

6001 Destination Parkway

Orlando Ballroom I; Lower Lobby Level

Orlando, Florida 32819

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