Developing Questions: The Prostate Cancer Surveillance Research Initiative

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A conference to develop a list of research questions related to the clinical use of active surveillance in management of prostate cancer.

About this event

Registration for the 13th automatically enrolls you in day 2 on December 16th from noon- 4 p.m. A calendar hold will be sent out once you are registered.

The Developing Provocative Questions: The Prostate Cancer Active Surveillance Research Initiative is a 2-day virtual conference brought to you by the University of Maryland and others, with funding support from Patient-Centered Outcomes Research Institute (PCORI). It is designed as a consensus-building initiative across multiple stakeholder groups (patients, clinicians, and academic researchers) to bring the communities together and discuss - in a structured way - challenges associated with the clinical use of active surveillance (AS) in management of favorable-risk forms of prostate cancer, and to identify a prioritized list of unanswered questions in the so-called PICOT (Population, Intervention, Comparison, Outcome, and Time) format.

The core objectives are to identify well-formatted questions amenable to well-structured research projects AND to bring together interested parties to work in a collaborative manner to address those questions, while continuing to think about the longer-term needs for research into AS.

Key participants in this conference will include:

Urologic oncologists, urologists, and other physicians experienced in the management of early-stage prostate cancer

Prostate cancer patients who are on, have been on, or have considered initial management on AS

Prostate cancer patients who received first-line invasive treatment for early stage prostate cancer but who, in retrospect, believe that AS might have been a better option

Non-medical caregivers or supporters of men with favorable-risk forms of prostate cancer (e.g., spouses, partners, children of patients, etc.)

Other researchers with an interest in development and management of prostate cancer (including biological, psychosocial, and other factors)

Opening session: Background to the conference

Working Session 1: Improving methods to increase access to and acceptance of AS among different populations

  • Men with favorable intermediate-risk prostate cancer (Gleason 3+4 or Grade Group 2)
  • Men younger than 60 years of age
  • Men with a family history of relatively high-risk prostate cancer
  • African American men

Working Session 2: AS interventions: Does the method matter? Identifying the methods of AS in greatest need of further study to improve access and acceptance of AS

  • Optimal integration of imaging in AS
  • Optimal integration of PSA testing and biopsies (frequency of checks, type of biopsy)
  • What can I do (if anything) to prevent or delay disease progression (lifestyle, supplements, Rx)?

Optimal integration of additional biomarkers (current and future)

Working Session 3: Which outcomes matter most? Proposed improvements to AS in future studies

  • Progression of cancer to a higher-grade cancer and potential to delay such progression
  • Loss of opportunity to get curative treatment (spread of cancer as metastatic disease)
  • Cancer-specific survival from prostate cancer as a cause of death
  • Continued compliance with AS (lowering frequency of premature discontinuation)?

Working Session 4: How setting impacts access and acceptance of AS

  • Presence of settings where physicians are incentivized financially to offer specific forms of treatment
  • Presence of cultural bias that may influence a patient’s receptiveness to different forms of management
  • Differences (or lack of differences) in care in community practices vs. academic medical center practices
  • Variation of practice patterns in different parts of the US (and as compared to other countries)

Other considerations for attendees

The “Developing Provocative Questions: The Prostate Cancer Active Surveillance Research Initiative” is a collaborative effort between the University of Maryland School of Medicine and the PATIENTS Program at the University of Maryland Baltimore School of Pharmacy (This conference was funded through a Patient-Centered Outcomes Research Institute (PCORI) Eugene Washington PCORI Engagement Award EAIN-19842)

Videography statement: This meeting will be recorded. Information in this conference should not be taken as medical advice. Any information a patient willingly shares about a personal experience is completely voluntary and waives HIPAA rights.

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A special thank you to all of our presenters!

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Organizer The PATIENTS Program

Organizer of Developing Questions: The Prostate Cancer Surveillance Research Initiative

The PATIENTS Program is an interdisciplinary research team of community partners and researchers housed at the University of Maryland School of Pharmacy that works to change the way we think about research by creating a path for health equity in West Baltimore.

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