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CTAF: Janus Kinase Inhibitors for Rheumatoid Arthritis

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Oakland Marriott City Center

1001 Broadway

Oakland, CA 94607

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The California Technology Assessment Forum will convene to review ICER's assessment of JAK inhibitors for rheumatoid arthritis.

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The California Technology Assessment Forum (CTAF), a core program of the Institute for Clinical and Economic Review (ICER), will hold a public meeting on December 9, 2019 to consider the comparative clinical effectiveness and value of JAK inhibitors for rheumatoid arthritis.

Rheumatoid arthritis is the most common autoimmune inflammatory arthritis in adults, affecting between 1.3 and 1.8 million Americans. The disease is more common in women and may occur at any age. Rheumatoid arthritis is typically characterized by morning stiffness and symmetrical joint swelling of the feet, hands, and knees, although any joint (and in some cases, internal organs and skin) may be involved.

Over the past 18 years, the introduction of targeted immune modulators, including JAK inhibitors, has greatly improved prognosis for many patients. There are currently three JAK inhibitors approved by the FDA for RA: tofacitinib (Xeljanz®, Pfizer), baricitinib (Olumiant®, Eli Lilly), and upadacitinib (Rinvoq®, AbbVie). JAK inhibitors are small molecules taken orally that work by inhibiting the JAK enzymes, which mediate intracellular signaling pathways involved in the production of inflammatory cytokines.

A presentation of the evidence will be followed by a public comment period and deliberations and votes by CTAF. The votes will be followed by a policy roundtable discussion. This is ICER's second review of treatments for rheumatoid arthritis, the first of which took place in 2017.

A list of key dates for stakeholder engagement opportunities and other important information associated with the review of JAK inhibitors for rheumatoid arthritis can be found on ICER's website at https://icer-review.org/topic/arthritis/.

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Oakland Marriott City Center

1001 Broadway

Oakland, CA 94607

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