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Conference on Pharmaceutics & Novel Drug Delivery Systems (cse) AS

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18th International Conference on Pharmaceutics & Novel Drug Delivery Systems


About Pharmaceutica Meet

We cordially welcome all the participants around the globe to attend our event Pharmaceutica Meet 2019 entitled “18th International Conference on Pharmaceutics & Novel Drug Delivery Systems” scheduled during April 25-26, 2019 in Istanbul, Turkey which includes a wide range of prompt keynote presentations, Poster presentations, Oral presentation, Exhibitions, Symposiums & Workshops. It is a proper platform for researchers, scientists and delegates to share their experience, Poster collaborations across industry and academia, and evaluate emerging technologies across the world.

This NDDS Conference is one of the well-established & important conferences among Pharmaceutical Conferences. Pharmaceutica 2019 is a specially organized two-day event which mainly deals with the importance and approaches of NDDS including pharmacokinetics, pharmacodynamics, non-specific toxicity, immunogenicity, biorecognition, and efficacy of drugs, Pre-Formulation & Formulation Aspects, Drug Targeting, and Designing etc. In the 21st century, NDDS used to treat a wide range of severe disease by enhancing its performance in terms of patient compliance, safety, and efficacy.

Scope & Importance:

Pharmaceutica Meet 2019 promises to revolutionize our lives through the approaches of discussion & research work about the new medicine, various dosage form, their formulation, route of administration, Efficacy, interaction, mechanism of action within body & their pharmacological, therapeutic effect & some post marketed study like adverse drug effect, patient acceptance. The conference organizers aim is to gather the doctors, professors, researchers, students, other faculty members, academicians, pharmacists, experts and scientists from the pharmaceutical field and Novel drug delivery community to create an opportunity of global exchange of information on technological advances, new scientific innovations, patient comfort, therapeutic effect of drug and the effectiveness of regulatory programs, application, future prospects, importance of the novel drug delivery system.

Why Attend:

Pharmaceutica Meet 2019 is a two-day scientific program held in Istanbul, Turkey which will give you an international communication platform in the pharmaceutical sector and will give you a vast opportunity to meet a lot of eminent people such as scientist, researchers, professors, head of companies etc. This conference will definitely help you to gather a lot of knowledge through the research talks, exhibitions, workshops, and presentations & a lifetime experience also. Thus, it’s a great opportunity to concrete your ideas and meet the experts from across the world. Our past conferences on the same topics were highly successful, so this year we expect for the same & that’s why your valuable presence really means a lot to us.

So, we welcome all interested participants to join us for our conference on Pharmaceutics & Novel Drug Delivery Systems in 2019 at the exquisite & heavenly beautiful destination of Istanbul, Turkey.

Why Istanbul:

Istanbul becomes one of the world’s best places for any international event or conferences & a growing knowledge hub. Not only that Istanbul is the best place to be when it comes to any international events or any type of business with easy accessibility, top-notch infrastructure, and modern venues. Istanbul is additionally very positioned on the International Congress and Convention Center's city rankings for gatherings in every ongoing year. This merited prevalence without a doubt originates from Istanbul's particular capacity to mix its notable social fortunes with present-day foundation, enchanting cordiality, and quality lodging.

All types of the hotel according to budgets are available in Istanbul & this cosmopolitan city is safe and secure for all. The weather in Istanbul during April-May is an absolute pleasure for all type of people due to the temperate spring & autumn weather. The city is also rich in adventures and experience due to a wide range visiting the place, exquisite natural beauty of UNESCO world heritage site & sea. Istanbul also provides a world-class transportation system. This Turkish city also famous for the delicious multi-cuisine food & world class restaurant. Istanbul has top-notch business event facilities, from a meeting room for a few people to a conference for a large no. of people. At last the main thing is that the Istanbul has the supply of a sufficient amount of money & top-notch infrastructure for research work & production and development of the new product.

Target Audience:

  • Students, Scientists, and Faculty of Pharmaceutical Universities

  • Medical Colleges, Eminent Researchers from Pharmaceutical Companies

  • Business Entrepreneurs, Software developing companies

  • Medical devices Manufacturing Companies, CRO

  • Clinical Data Management Companies.

  • Ph.D. Scholars & Researchers

  • Manufacturers, Distributors, and Suppliers of Drug Delivery Technologies

  • President, Directors, CEO’s of Organizations

  • Health professionals & Pharmacists

  • Graduates and postgraduates in pharmacy

  • Noble laureates in Health Care and Medicine

  • Members Research Institutes & Training Institute

  • Pharmacy Associations and Societies

  • Drug Control Officer & Head Of Drug Laboratories.

  • Quality control specialist


Sessions/Tracks

Track 01: Novel Drug Delivery System

It is defined as the method by which a drug is delivered can have a significant effect on its efficacy i.e. the drug become more efficacious in order to minimize drug degradation, drug adverse effect, and in order to increase the drug bioavailability to produce the better therapeutic effect. NDDS covers various aspects like pharmacokinetics & pharmacodynamics, non-specific toxicity, immunogenicity, biorecognition, and drug’s efficacy based on preferable approaches that include polymer science, pharmaceutical technology, dispensing pharmacy, packaging technology, bioconjugate chemistry, and molecular biology. NDDS based on two mechanisms i.e. physical and biochemical. The physical mechanism is like dissolution, osmosis, absorption, distribution, bioavailability, excretion and diffusion. The biochemical mechanism is like gene-protein therapy, liposomes-niosomes, Nano-micro particles, Monoclonal antibodies.

NDDS used to treat a wide range of severe disease by enhancing its performance in terms of patient compliance, safety, and efficacy. Various drug delivery carriers & medical devices are used to enhance the NDDS through their target-specific controlled action. Like – nanoparticles, Nanoshell, Nanotube, microbubbles, microsponges etc. They are administered to the body through a specific way to reach the target site & release the medicaments incorporated in it after binding with the receptors in a controlled manner to show the better therapeutic effect.


Track 02: Pre-formulation Study

Pre-formulation studies are an important aspect for various stages of clinical trials & it is the 1st stem in the formation of the dosage form. Before the formulation of the pharmaceutical product, the pre-formulation studies are necessary. The main objective is to generate information useful to the formulation in developing physicochemically & biochemically stable & bioavailable dosage form. The various pre-formulation study is – 1. Bulk Properties; 2. Polymorphism & Particle Size; 3. Hygroscopicity; 4. Aqueous Solubility; 4. Ionization Constant; 5. Partition Coefficient; 6. Drug Dissolution; 7. Drug Stability; 8. Drug Compatibility; 9. Half-Life of the drug; 10. Drug Absorption.

Through the determination of physicochemical properties of inventing molecule, It states the steps of preparing drug delivery that enhance the drug performance & development of an efficacious, stable and safe dosage form. Nowadays the pre-formulation studies have become more accurate & comfortable with the help of the statistical software based on artificial neural networking. These approaches accumulate the data regarding the degradation process, toxicological effects, and adverse reaction. So Pre-formulation is a necessity in drug development & discovery.


Track 03: Pharmacokinetic & Pharmacodynamics Study

In a simple word Pharmacokinetic is that what the body does with the drugs and reciprocally Pharmacodynamics is that what the drugs do with the body. Both are a very common term of pharmacology. Pharmacokinetics consist of – 1. Absorption of the drug molecule by the body membrane; 2. Distribution of the drug to the organ and systemic circulation; 3. Metabolism of the drug molecule and attachment to the plasma membrane; 4. Excretion of the unused or excess drug or residue through urine or stool. The above 4 processes collectively called as ADME. Apart from that, another one term is there that’s called bioavailability which is defined as the amount of drug available after absorption to work in the body and introduce into the systemic circulation.

Now the pharmacodynamics is included – 1. Mechanism of Action – Specific biochemical interaction and reaction which the done with the body to produce a specific therapeutic effect; 2. Pharmacological Action – The therapeutic changes in the body due to the drug action; 3. Adverse Effect – The unusual effect of the drug differs from the desired pharmacological effect, which is a threat to the patient.


Track 04: Medical Drug Delivery Devices

Drug delivery devices are mainly used to reach the drug or medicaments to the site of action in a particular way. They are also employed to inject the drug through a particular route on the basis of disease type, dosage form, target site etc. Those devices increase the activity of the drug delivery system by controlling time, dosage form, dose, and releasing site of the drugs & action site in the body. Target specificity, specific therapeutic effect, dose-optimization and a high degree of safety and efficiency are the distinctive features of these devices. Medical devices can be conventional or implantable.

Global drug delivery devices market is growing gradually due to increasing demand, advanced manufacturing technology, rising geriatric population and cancer patient. Some of the devices are Computed tomography scanning(CT), Magnetic resonance imaging(MRI), Ocular insert & Insulin jet, Implantable devices & Nebulizers. Medical devices prepared for the pulmonary and nasal route are quite popular nowadays. These routes are intended for local delivery, as in asthma, but also for fast and accurate delivery of drugs to the systemic circulation and direct delivery to the CNS.


Track 05: Route of Drug Administration

Route of administration is the path through which the drugs or any dosage form are administered into the body. The route of an administration divided into – 1. The location at which the dosage form is applied, 2. The Target action. The routes of administration are very much important for the proper mechanism of action and therapeutic action of the drug. Selection of route mainly depends upon three factors – 1. The mechanism of action of the drug within the body, 2. The formula of the drug, 3. The treated part of the body.

Most of the novel formulation generally administered through the parenteral route like intravenous, intramuscular, subcutaneous, oral etc. to avoid the contamination and the drug degradation. If the drug is given through intravenous path then bioavailability should be 100 % & the therapeutic action will be a lot better. Some drugs or formulation requires a specific route for their administration to work perfectly in the body by triggering the specific receptor or site. Sometimes also the route of administration is determined on the basis of site of action.


Track 06: Targeted Drug Delivery System

Targeted drug delivery is a type of intelligent drug delivery system. Mainly it is a mixture of sustained & controlled drug delivery system. This is a method of administering medication to a patient in a way that higher the level of concentration of the drug only in a particular portion of the body. The drug after administration reaches the specific site of action, then they attach with the diseased tissue. The key driver of this drug delivery system is prolonged, slow, controlled but protected action of the drug towards the tissue for a longer period of time to exhibit the proper & exact therapeutic effect & promote the treatment.

The supremacy of the targeted drug delivery is 1. Dosage frequency or dosage count reduction by the patient to avoid error. 2. Prolonged & uniform effect of the drug. 3. The decrease in side effect or adverse drug reaction. 4. Drug level fluctuation reduction i.e. uniform drug concentration. 5. Maintenance of the uniform plasma drug level due to controlled release. There are two types of targeted drug delivery- 1. Actively targeted drug delivery that is antibody medications and 2. Passive targeted drug delivery such as the enhanced permeability and retention effect.


Track 07: Nanotechnology in Drug Delivery

Nanotechnology drug delivery system mainly improves and elevates the efficacy & action of any medicaments, creating new and better product. Nanoparticle brings revolutionary changes by simplifying the complex tissue culture through reconstruction. Hence the nanoparticle used to deliver the drugs particle or medicament to the specific site, receptors or disease cell. Then the drug particle attached to the specific receptors & attracted by the diseased cell. After that, they started working & provide treatment. The main advantage of nanotechnology is proper & specific action and less damage to the healthy tissue.

There are many types of nanotechnology dependent detectors and devices are available like nanotubes, nanowires, Nanoprobes Nanoarrays, polymer nanoparticle, gold nanoparticle, the magnetic nanoparticle, Nanocapsule, Nanoshell etc. Nanotechnology is the engineering of functional systems at the molecular level & manipulating matter at the Nanoscale. Nanomedicines are widely used in the cancer therapy. There are four types of nanotechnology-based drug delivery systems – 1. Smart drug delivery systems, 2. Polymer-drug conjugates, 3. Multifunctional drug carriers, 4. Organic/inorganic composites.


Track 08: Herbal Novel Drug Delivery

Nowadays, considerable attention has been focused on the development of novel drug delivery system for herbal drugs. There are various advantages of using herbal drugs like – No side effects, More Effectiveness, Lower cost & sufficient availability. Novel drug delivery overcomes the limitation of traditional drug delivery systems. We have a vast knowledge of Ayurveda but the techniques of administration we follow are outdated now. Combination of novel drug delivery technology & herbal medicine may help in increasing the therapeutic effect and decreasing the adverse effects of various herbal formulations. So it is important to integrate a novel delivery system and Indian herbal medicines to combat many diseases.

Various types of formulation are used in the herbal novel drug delivery like- Liposomes, Niosomes, Phytosomes, Transferosomes, ethosomes & dendrimers. Reasons for using herbal medicines are - 1. Increasing concern over the efficacy and safety of drugs 2. Failure of modern medicine to treat most common disease. 3. Herbal medicines are giving better results without less or no side effects.


Track 09: Vaccine Delivery System

A vaccine is a biological preparation that provides active adaptive immunity to a particular disease. Vaccine generally contains a component that is usually a disease-creating microorganism and is often made from weakened or killed forms of the microbe, pathogen, its toxins, or one of its surface proteins. There are many types of vaccine like – 1.Inactivated, 2.Attenuated, 3.Toxoid, 4.Subunit, 5.Conjugate, 6.Experimental, 7.Valance, 8.Heterotypic. The administration of the vaccine into the body is called vaccination which is the most effective method of preventing infectious disease.

Immunization system contains two types of doses That is – Prime dose & Booster dose. Immunization failed if the patient ignores the booster dose. Booster doses are required to induce an effective immunity. For that reason to skip the booster dose, invention of new generation prophylactic and therapeutic vaccine are required to initiate more effective immunization. Nowadays vaccine allows the incorporation of doses of antigen, that’s why antigen released in a very controlled way. Here the transportation of vaccine to the specific site is done by the carriers in a sustained release and accurate targeting manner.


Track 10: Innovative Technologies of Drug Delivery

Drug delivery is the procedure of administration of a pharmaceutical drug component into the body through various ways to get the pharmacological action of the drug. Drug delivery technologies transform the drug release profiles, pharmacokinetic and pharmacodynamics parameters to improve product efficacy and safety, as well as patient convenience and compliance. In the recent days, the innovative & smart drug delivery technologies are very much important to reach the medicaments to the proper site through proper way. Traditional & conventional drug delivery system failed in most cases in this scenario. So to deliver the protein, peptide, gene, vaccine, nanoparticles, antigen and some special form of drug – the innovative drug delivery technologies are essential to avoid the enzymatic degradation, acid degradation & some absorption and bioavailability related problems.

There are many technologies are involved like - needle-free drug delivery, transdermal drug delivery, fiber-based delivery for implantable devices, targeted penetration drug matrix technology for non-invasive drug delivery and location-specific Nanodevices for chemotherapeutic medicine delivery. Not only that many other innovative technologies of novel drug delivery have been developed like- implantable devices, Nanotubular drug delivery, protein peptide encapsulation, microfabrication & chemical transformation.


Track 11: Nanoparticles

Nanoparticles are particulate dispersion with a size range of 10-1000 mm and consist of perishable materials like natural or synthetic polymer. The drugs are dissolved, dispersed & attached to the nanoparticle matrix. The nanoparticles are solid in nature & available in crystalline or amorphous form. Generally, polymeric materials are used for the preparation of nanoparticles. In Nanocapsule drugs are incorporated in a cavity surrounded by the polymeric membrane but in Nanosphere drug is uniformly shielded in polymer matrix system. Active targeting of the drugs at the specific site can be fulfilled by attachment of drug molecule with tissue or cell-specific ligand but the passive targeting happened by the dispersion of the drugs in the polymer of Nano or Microparticle.

The key characteristics of the nanoparticles are - 1. improve the therapeutic activity and minimize adverse drug reactions associated with available drugs; 2. activate new classes of therapeutics; 3. Accelerate the re-invention of pharmaceutically ignored but biologically active new molecular substances that were previously underestimated. They are used in a targeted drug delivery system to enhance the solubility of the poorly soluble drug and also help in gene-drug delivery.


Track 12: Drug Targeting & Drug Designing

Drug designing also was known as rational drug design. It is the research process of exploring new drugs or medications based on the study of a biological receptor target. The drug is an organic small molecule that accelerates or retardate the activity of a biomolecule such as a protein, peptide, gene etc. which results in the better therapeutic activity for the patient. Drug design discusses the design & shape of drug molecules for perfect attachment to the targeting receptor or site to give the proper pharmacological effect. Drug designing often depends on the computer modeling technique which is called the computer-aided drug designing (CADD). If the drug design depends upon the 3D biomolecular structural target i.e. called structure-based drug designing. To a broad sense, drug design is called ligand design because of tightly binding of the drug molecule to its target.

Drug designing also improve the targeting of the drug molecule to the specific site or receptor and also tightening the binding of the molecule at the receptor binding site. Hence the therapeutic activity increases heavily.


Track 13: Controlled & Sustained Release Drug Delivery

Controlled drug delivery is that type of system which releases the medicaments from the dosage form at a predetermined specified rate for locally or systemically for a specified period of time. The main advantages of controlled drug delivery are – 1. Low amount of administered doses; 2. Less gastrointestinal side effects; 3. Less dosing frequency; 4. Improved patient acceptance & compliance; 5. Fewer ups & downs in plasma drug concentration; 6. Highly uniform drug action & effect; 7. Enhanced efficacy & drug safety.

The sustained release formulation is those which give slow but prolonged action. I.e. giving an action for a long period of action without hampering the drug concentration. Sustained release formulation maintains uniform drug plasma concentration. But all type of medicaments cannot be administered through the sustained release drug delivery. Enteric coated tablet and capsule, the implantable tablet is the example of this type of system. Reservoir type of mechanism is associated with this type of system.


Track 14: Recent Research & Advances

The aim of drug delivery systems is to deliver medications to specific site & receptors of the body through a medium using the carrier, vehicle or medical devices that can control the therapy’s administration. To fulfill this aim, researchers are turning to advances in the worlds of microtechnology and nanotechnology. Biological experts may be re-invented for blood bone barrier transport with the activity of molecular Trojan horse technology. Needle-free drug delivery technology is novel delivery ways to administered various medicines to the body for injecting powdered drugs into the skin.

Transdermal patches are user-friendly, convenient, cheap and painless and offer better patient compliance. Some Anti-cancer drugs such as loperamide and doxorubicin attached & dispersed to the polymer matrix of nanomaterial have been shown to cross the blood-brain barrier. The recent advances in the protein & gene peptide drug delivery systems are PEGylation and Depo-foam technology. The cell penetrating peptide shows their biological action through the transportation of hydrophilic macromolecules to the cell. New drug delivery technology includes lipid, protein, gene, & polymeric technologies to produce new targeted drug delivery with better body distribution, drug protection, drug safety, better efficacy, patient compliance & therapeutic effect from harsh external environment and avoidance of drug clearance.



Track 15: Global Market & Pharmaceutical Formulation

Currently, North America has surpassed the entire continent in terms of novel drug delivery market in cancer research with a market share of around 38%. Due to excellent research & development in the field of drug delivery system, the exceptional adoption rate of new technologies, helpful reimbursement policy – North America has surpassed all the continents in terms of market share. Europe also holds the 2nd position with a very respective market share of around 29% due to a large number of the cancer patient, development of clinical research facilities, awareness & the novel therapy to the cancer patient.

But Asia is the fastest growing novel delivery market & it shows a huge elevation in growth curve during recent times due to vast research activities, awareness, new therapy procedure, increased no. of the cancer patient in China & Japan. Currently, it holds the 3rd position in the global market with a share of around 20% but in future, it is expected to boost the market growth. The total value of global NDDS market in 2016 was $4.31 Billion. The growth is boosted at a rate of 22.9% during the recent period according to CGAR report.

Various novel pharmaceutical formulations are including the Nano medicine, transdermal patches, enteric coated tablets & capsule, implantable tablet, injectable intravenous & intramuscular preparation, microbubbles & microsponges, various Nanoparticles, microsphere etc.



Track 16: Obstacles in Drug Development & Discovery

In spite of invention of various new drugs, several challenges & problems are untouched and i.e. why compensation of our resources is necessary for the solving of the problem, development of new drugs, and new methods of treatment. Regulatory requirements and commitments have elevated heavily day by day and this lead to a rise in both the trial size and the length and hence the overall cost of the development process becomes very high. The selection of the novel drug from a variety of solution is also a challenge and the development procedure is also very hectic. But the current effort of development of drugs using innovative technologies becomes ineffective due to expensive clinical and preclinical data studies.

To overcome the challenges some steps can be taken like – 1. Cost efficient alternative development model can be prepared; 2. Innovation in the development procedure; 3. Employment of more educated, experienced & technically abled specialist. Postmarketing adverse drug reaction is also a major problem in this field i.e. why proper clinical research is required. The drug development model today is under a big threatening situation as the number of drugs approved for marketing has decreased to an all-time low. The developers are aware of this trend & try their best to overcome that.


Track 17: Limitations of Novel Drug Delivery System

In spite of having a huge freedom and advantages of NDDS, it also has some drawbacks and limitation. The administration and implementation cost of Nanomedicine is much more expensive. Cytotoxicity of the nanoparticles also becomes a threat for the future. Nano product facing greater problem due to their much higher cost and complexity. The limited availability and lower production rate of personalized medicine & device are problematic for a large amount of user. Some innovative & noninvasive delivery improve the patient acceptance by lowering the marketed price & production cost. I.e. Why these results in the product degradation & quality issue.

Novel drugs which are administered through the oral cavity should possess the risk of undergoing acid or enzymatic degradation or hydrolysis. Some medical devices like Nanoshell, Nanotube, Nanopores are difficult to administer into the body of some patient, baby, or old people. All type of drugs or medicine cannot be administered through the nanoparticles, carriers or devices because they cannot be incorporated in the polymer matrix or they can be degraded. But the scientist and researchers are continuously trying to overcome the drawbacks through their invention.


Track 18: Application & Future Prospects

There is a wide range of application of the novel drug delivery system to the mankind includes - 1. Targeted & controlled drug delivery; 2. Faster action; 3. Used in the treatment of many severe diseases like cancer; 4. Administration of those drugs which cannot be administered through the conventional drug delivery system; 5. Triggering of the target site, receptors or affected cell through the Nanoparticulate drug delivery; 6. Higher success rate; 7. Comparatively cheap but costly administration cost; 8. Delivery of protein-peptide drugs; 9. Immune response study; 10. Transdermal drug delivery; 11. Fewer side effects.

Pharmaceutical innovations like the Novel Drug Delivery Systems present health professionals with a broad range of arsenals to treat diseases with never before efficacy, safety, and precision. Clinically the NDDS not only smoothens the saw-tooth pattern of drug levels in the blood but also affords to target the drugs to their site of action and thus reduces dose-related side effects. The smaller quantity of drug and fewer numbers of dosing could be used to treat a disease with increased success. It is hoped that with more and more research endeavors being focused into this arena, in near future, a large portion of the conventional dosage forms would be replaced by these NDDS and an overall betterment of health care delivery is expected with that changeover. Pharmaceutical companies are interested to conduct research on NDDS to get an edge over the big pharmaceutical companies to capture the regulated market through ANDA in the regulated market. Moreover, the development and implementation of new branches like Pharmacovigilance will ensure availability of safer medicines to our people. Pharmacoeconomics will provide cost-effective health care, which may help to extend the health care to the underprivileged.


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