Computational Systems Biology (CSB), with its focus on mathematical and computational modeling of complex biological systems, provides new insights into the functioning of organisms at different scales. Properties and interactions of entities within cells, tissues and organs, together with associated biological networks, can now be studied in ever-increasing detail through multi-scale methods. Advances in CSB can offer many promises for life science. One of the most prominent of these is certainly in the field of biomedicine. Understanding the relationships between the entities studied in CSB and their impact on human health is a subject of great interest in medicine. Many methods in diagnostics, genetics, gene therapy, immunology and others are developed through the application of CSB. There is no doubt that many more will be developed in future.