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Chronic Inflammation Biomarkers in Disease Development and Prevention

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Trans-NIH Workshop on Chronic Inflammation

5635 Fishers Lane

Rm 508/509

Rockville, Maryland 20852

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ABOUT THE MEETING

Chronic inflammation is commonly accepted as an initiator of different human diseases. Several studies have demonstrated a strong correlation between chronic pro-inflammatory state and the development of a disease including malignant transformations, blood vessel and brain disorders, and degenerative diseases. Despite continued studies on causes of inflammation and inflammation-associated biomarker discovery and the association between inflammation and diseases, further inquiry is needed to develop further understanding of this condition and its progression to the disease state.

This workshop brings together experts from multiple research disciplines in different disease areas who are investigating chronic inflammation and its role in disease development. The goal of this workshop is to assess current findings, state-of-the-art techniques and enabling technologies for deeper insight into disease-promoting inflammation. Specific discussion topics include:

(1) Molecular mechanisms of inflammation: overview of current knowledge on the role of chronic inflammation in disease development

(2) Biomarkers of inflammation: tools and techniques for biomarker discoveries and epidemiological studies in disease-focused inflammation

(3) Imaging/sensing inflammation: in vivo imaging technologies to detect impending or localized inflammation

(4) Big Data of inflammation: data analysis and integration strategies for complex data derived from inflammation research, and

(5) Clinical implications of inflammation: early detection of disease and disease prevention, treatment and management.

Participants will examine needs, challenges and assess approaches that can improve accuracy in gauging an individual’s inflammation status associated with impending diseases or disease resolution through comprehensive multidisciplinary strategies.

AGENDA

Day 1, May 31, 2017

7:45 am Registration

8:15 am Welcome and Introduction

8:25 am Inflammation of Age Vishwa Deep Dixit, DVM, Ph.D., Yale School of Medicine

8:55 am Mechanisms of Chronic Inflammation in Disease Initiation & Resolution

  • Molecular Mechanisms in Chronic Inflammatory Disease: Novel Concepts from the Study of Periodontitis George Hajishengallis, DDS, Ph.D., University of Pennsylvania

  • Genetic and Epigenetic Modification of Chronic Inflammatory Diseases-a Periodontal Disease Perspective Rogerio Castilho, DDS, Ph.D., University of Michigan

9:45 am Coffee break

10:05 am Mechanisms of Chronic Inflammation in Aging, Cancer, and Neurological Diseases

  • Bridging the Gap between Cancer and Chronic Disease of Aging Judith Campisi, Ph.D., Buck Institute for Research on Aging

  • Cancer as a Disease of the Symbiont/Metaorganism Giorgio Trinchieri, MD, National Cancer Institute

  • Systemic, Targeted Nanotherapies for the Diagnosis and Treatment of Neuroinflammation Kannan Rangaramanujam, Ph.D., Johns Hopkins School of Medicine

11:20 am Panel Discussion

12:20 pm Lunch

1:20 pm Development/Discovery of Disease-promoting Inflammatory Biomarkers

  • Elucidating the Associations of Inflammatory Biomarkers with Cancer Risk Adetunji T Toriola, MD, Ph.D., Washington University School of Medicine, St. Louis

  • Development of Chronic Disease Biomarkers Based on Inflammation and Adaptive Immunity Russell P Tracy, Ph.D., University of Vermont

  • Biomarkers and Endpoints in Inflammatory Ocular Diseases: Challenges and Limitations Penny Asbell, MD, Mount Sinai School of Medicine

2:35 pm Coffee break

2:50 pm Imaging/sensing Inflammation

  • Photoacoutic Tomography: Omniscale Imaging from Organelles to Patients Lihong Wang, Ph.D., California Institute of Technology

  • Positron Emission Tomography of Human Brain Can Monitor Neuroinflammation Robert Innis, MD Ph.D., National Institute of Mental Health

  • High Content Single Cell Based Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles John T McDevitt, Ph.D., New York University

  • MR Imaging of Inflammation: Can We Go Beyond the Macrophage as Primary Target? Jeff W.M. Bulte, Ph.D., Johns Hopkins University

4:30 pm Panel Discussion

5:30 pm Wrap-up

________________

Day 2, Jun 1, 2017

7:30 am Registration

8:00 am Goals and Objectives

8:10 am Connecting the Dots - from Big Data to Healthy Heart Peipei Ping, Ph.D., University of California Los Angeles

8:40 am Big Data/Multi-omics Approaches in Identifying Inflammation Biomarkers

  • Using Population Study Resources to Study Chronic Inflammation and Move Towards Diagnostic Tools Jeremy D Walston, MD, Johns Hopkins School of Medicine

  • Connectivity Map Todd R Golub, MD, Dana-Farber Cancer Institute

  • Molecular Interdependencies in Inflammation and Aging: What Can We Learn from Hypothesis-free Integration of Multi-omics Data Using Graphical Modeling, Gabi Kastenmuller, Ph.D., Helmholtz Center Munich, Germany

9:55 am Coffee Break

10:15 am Clinical implications of Disease-promoting Chronic Inflammation and Prevention Strategies

  • Is there a Role for Immune Markers in Irritable Bowel Syndrome? Margaret Heitkemper, Ph.D., RN, University of Washington

  • Aging, Inflammation and Function: Potential to Change the Trajectory of Decline Anne Newman, MD MPH, University of Pittsburgh

  • Resolution of Inflammation by SPM: Potential Biomarkers and Therapeutics in Chronic Inflammatory Diseases Thomas E. Van Dyke, DDS Ph.D., The Forsyth Institute

11:30 am Panel Discussion

12:30 am Wrap-up


DIRECTIONS

AIRPORTS/METRO/PARKING

Reagan National Airport (DCA) is the closest airport connected to the Washington Metro. Dulles International Airport (IAD) and Baltimore-Washington International Airport (BWI) are approximately 45 minutes from the meeting location.

The meeting location is closed to Twinbrook Metro Station on the Red Line of the Washington Metro.

There is a parking garage behind the meeting site which charges $7 per day (rate is subjected to change).

LODGING INFORMATION

We have reserved a 50-room block at the EVEN Hotel Rockville for this workshop over the dates May 30 and June 1, 2017, at a special rate of $152.00 plus tax for a single room. This hotel is about 0.6 miles (about a 15-min walk) from the meeting site. The cut-off date is May 9, 2017. You can make your room reservation through one of the following:

  • Phone at 855.TRY.EVEN (855.879.3836) or 301.881.3836 for Reservations Department and refer Group Name Chronic Inflammation Biomarkers in Disease Development and Prevention (E10)

  • Online at www.evenhotels.com for reservations and enter group code: E10

CONTACT

For additional information about this workshop, please contact christina.liu@nih.gov.

NIH VIDEOCAST

This meeting will be live on NIH VideoCast on both meeting dates. Please register to attend the VideoCast.

Link for Day 1: https://videocast.nih.gov/summary.asp?live=22056&bhcp=1

Link for Day 2: https://videocast.nih.gov/summary.asp?live=22060&bhcp=1

NOTE

Events listed below the "TAGS" are not associated with or endorsed by the National Institutes of Health

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Trans-NIH Workshop on Chronic Inflammation

5635 Fishers Lane

Rm 508/509

Rockville, Maryland 20852

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