Boston Training: Get Started with Reaction Optimization and Scale-up using DynoChem
Tuesday, September 17, 2013 at 9:00 AM - Wednesday, September 18, 2013 at 4:30 PM (EDT)
Join the DynoChem training team for two days of hands-on training, using DynoChem to accelerate process development and scale-up projects.
Training will address DynoChem applications for scientists in API process development groups involved in tech transfer, troubleshooting and optimisation of API reaction, workup and isolation steps.
The agenda will cover topics such as:
- Modelling reactions using HPLC data, then using the models for reaction optimization
- Minimizing the number of experiments required
- Finding optimum temperature, equivalents and reaction time to maximize yield and minimize impurities
- Preventing problems when scaling up or transferring to/ from CMOs
- Reaction types including batch, irreversible, homogeneous through to fed batch, equilibrium, catalysed and heterogeneous
- Chemistries including halogenation, esterification with acid catalysis and Suzuki Coupling
- Phase equilibrium calculations for boiling point, identifying azeotropes and miscibility
Training times will be from 9:00 to 4:30 each day, with 6 hours of tuition. You will need a laptop computer with DynoChem installed and a wireless network capability. We will provide a temporary license of DynoChem for the duration of the training and the following week. Alternatively, computers with DynoChem installed may be provided for your convenience - let us know if you will be needing one and we will confirm the additional cost.
By the end of the course, trainees will be able to:
• Draw and understand process schemes and use them to help think about how to model or design experiments to understand a new or existing process
• Model chemical reactions, including kinetics, temperature-dependence, reaction orders
• Fit chemical kinetics to typical lab data
• Optimise reactions for yield and impurity levels
• Generate response surfaces to study process robustness and determine design space for QbD submissions
• Further develop initial models to include multi-phase, scale-up and interpretation of analytical data
• Look up physical properties for pure components and mixtures.
Refund / cancellation policy:
1. Substitutions can be made at any time before the training.
2. For cancellations made in writing up to one week before the training, a full refund will be made, less a financial charge of $100.
3. No refunds can be given for cancellations less than one week before the event.
4. Registration is open to DynoChem customers and prospective customers from industry, academia and government.