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Aptean GenomeQuest: Searching for Variant Sequences with Pinpoint Accuracy

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Kimpton Marlowe Hotel

25 Edwin H. Land Boulevard

Alexis Gallery A

Cambridge, MA 02141

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Join Aptean GenomeQuest's Ellen Sherin at the PIUG 2019 Biotechnology Conference on February 19th to learn about the right tools for sequence variation searching.

Abstract:

Using existing tools to do variation searches is very difficult and labor-intensive, requiring multiple workarounds to get potentially incomplete results. Even writing the query sequence is very tedious and potentially error-prone. Since these tools don’t allow for variability elsewhere, nor do they highlight specific substitutions, a complete analysis requires extensive manual intervention. Not to mention, there’s no simple way to prepare a landscape report to provide the big picture of variations to a given sequence.

GenomeQuest addresses these issues with our Sequence Variation Discovery Module, designed to make variation searches a process that can be done routinely. Query sequences no longer need to be hand-written, and replacements and indels are specified with position, length, and residue-specific filters. By removing the 100% identity requirement for unmodified positions, mismatches at other positions won’t cause hits to be missed.

Take a look at just a couple of the features included in this module that we'll be diving into during this workshop:

  • Variation filters that may be combined with Boolean logic, and each position visualized with easy-to-understand graphics, either as a summary or as a detailed view; Filters may be applied to iteratively examine the effect of different combinations of variations
  • Variation Landscape Reports that can be created for an entire result set, with color-coding to indicate hotspots and conserved locations, and all variations at every position
  • Multiple levels of annotation that add layers of knowledge to search results

If you have any questions in the meantime, please contact us at info@aptean.com.

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Kimpton Marlowe Hotel

25 Edwin H. Land Boulevard

Alexis Gallery A

Cambridge, MA 02141

View Map

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