The gene therapy field has progressed significantly since the first successes in treating monogenic immunodeficiency diseases. Insertional mutagenesis of integrating vectors led to development and utilization of rapid throughput identification of genomic insertion sites in clinical usage. Evolving use of expandable, clonable and transplantable sources of stem cells and identification of genomic 'safe harbors', site-sirected integration and homologous recombination clearly may impact future clinical applications.
This meeting brings together international experts discussing state-of-the-art gene transfer and gene therapy clinical applications, new vector approaches and insertional & genome biology. The meeting is limited in size.