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9th International Conference on Emerging Trends in Liquid Chromatography-Ma...

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9th International Conference on Emerging Trends in Liquid Chromatography-Mass Spectrometry


About Conference

ConferenceSeries Ltd invites all the participants from all over the world to partake and attend World Devout Congress on Liquid Chromatography-Mass Spectrometry on September 21-22, 2018 in Tin Shui Wai, Hong Kong which would replicate the plethora of LC-MS from highly eminent professionals and exhibitors .

LCMS 2018 is a best platform to meet and share the knowledge with eminency related to academy and towards the industrial knowledge to furnish with the most curiosity deals in aspects of Mass Spectrometry and Chromatography. LCMS 2018 conference covers all the fields related to Mass Spectrometry and Chromatography. There will be many workshops and technical sessions to limelight the depth of LCMS that would be enormously enriched with the prospects of broadening the current scenario of the Mass Spectrometric Principles and Chromatographic views . The experts can withstand an excellent opportunity to bestow their best in expertise through presentations and lectures on different topics.

The main objective of this conference is to enlighten the innovations and current trends of Mass Spectrometry and Liquid Chromatography. This conference would bring together the personals who are interested in fields of mass spectrometry, chromatography and analytical chemistry to explore the ideas and replica concerned to relevant topics and generates solutions to decipher and deliver the huge shade of Mass Spectrometric and Chromatographic schemes of development.

ConferenceSeries Ltd organizes 1000+Conferences Every Year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 900+Open access Journals which contains over 60000 eminent personalities, reputed scientists as editorial board members.

Why Hong Kong:

The capital city of Hong Kong is Hong Kong. Hong Kong is one of the magnificent cities in the world. The official languages of Hong Kong are Chinese and English. Hong Kong is the Asia’s best shopping destination and it is one of the world’s expensive cities. Hong Kong has developed from a small fishing village in the 1800s into a dynamic and thrilling 21st century cosmopolitan metropolis. It is a bustling coastal city full of impressive high rises, and a fusion of eastern and western cultures. It proudly proclaims itself to be 'Asia's World City' and remains a key gateway to China. Hong Kong is home of both the highest-ranked Asian university in the QS World University Rankings (Hong Kong University at 23) and the number one university in the 2012 QS University Rankings: Asia (the Hong Kong University of Science and Technology), Hong Kong is truly a higher educational powerhouse. Hong Kong boasts a highly developed transportation network. It is very convenient to travel to and from Hong Kong. Hong Kong is a fusion of East and West. There is no better place to experience both eastern and western cultures, and experience traditional and modern life. Hong Kong is the ideal springboard for trips to the rest of China as well to other parts of East Asia. A visit to Hong Kong can include sweeping views of land, sea, and architecture, wonderful beaches, great hikes, and traditional fishing villages with a slower pace of life. Hong Kong is one of the most impressive cities in the world, certainly, but there's much more to the country than meets the eye. A visit to Hong Kong can give visitors views of wide–ranging lands, alluring architecture, pleasing sea, wonderful beaches, traditional fishing villages and adventure activities. Popular Hong Kong tourist attractions like Hong Kong Disneyland, Big Buddha, Tai o Fishing Village, Temple Street Night Market, Dai Pai Dongs, Wong Tai Sin Temple, Dragon's Back Hike, Avenue of Stars, Tsim Sha Tsui and Victoria Peak.

Who to attend?

· Directors of analytical chemistry department in Universities

· Research laboratories Scientist

· Professor and Associate professor of analytical chemistry

· Research scholars

· Analytical instrument manufacturing company

· Research and Development Department

Why to attend???

  • To learn about key issues in the industry (and your area of interest in particular) as articulated by practitioners.
  • To meet people and organizations addressing these same key issues.
  • To meet people with whom you’ve established a relationship on social media.
  • To initiate relationships with others that you can continue by social media and/or meetings in person.
  • To learn about job, internship, project and other work-based possibilities.
  • To learn about fellowship and grant opportunities relevant to your area(s) of interest.
  • To gain insight into the experiences of others who face challenges like yours.
  • To learn about publications and other resources relevant to your area(s) of interest.

Target Audience:

· Industry 30%

· Academia 60%

· Others 10%

Conference Keywords

  • Liquid Chromatography
  • Gas liquid chromatography
  • Mass Spectroscopy
  • Ionization
  • Biomolecules
  • Genetic Disorders
  • Combinatorial Chemistry
  • Agro-Chemistry
  • Bioanalysis
  • Forensic Chemistry
  • Food technology
  • Electrospray Ionization
  • Atmospheric pressure chemical ionization
  • Hyphenation
  • Pharmaceutical Research
  • Biomedical Research
  • Post-translational modification
  • Liquid–liquid extraction
  • Chromatography and High-Performance Liquid Chromatography (HPLC)
  • Therapeutics

1. Liquid Chromatography is a different method of analytical chemistry which is mainly used to separate and identify each element in a mixture. Now a days highly used technique is HPLC (High Pressure Liquid Chromatography) which has been used for production of Pharmaceutical and biological products. Is has different phase like stationary phase that is the type of absorbent material used as the stationary phase is vital for efficient separation of components in mixture and mobile phase which is chosen for the best separation of components in an unknown mixture.

2. Gas liquid chromatography is an analytical machine that measures the content of various components in a sample. The principle of gas chromatography is to inject the solution into the instrument and enter gas stream which take the sample up to the separation tube or column where helium or nitrogen gas is used. The work of detector is to measure the quantity of the components that exit the column and compared with the known sample to check results.

3. Mass Spectroscopy is a technique which is used for ionizes chemical compounds. This process is highly used in separation technique. Gas chromatography is used to separate different compounds. MS is highly common use in analytical laboratories that studied in physical although in chemical properties. MS generates different ions from the sample then separates them according to their mass-to-charge ratio. The MS instrument consists three major components like Ion Source, Analyzer, Detector System. This mass spectroscopy technique is basically studied the effect of ionizing energy on molecules.

4. Ionization is a process by which atoms and molecules exchange their positive and negative charge to form an ion by changing the chemical composition also. Ionization is highly used in fundamental science mainly in Analytical chemistry, Mass spectroscopy. In chemistry ionization often occurs in a liquid solution. In general, it occurs whenever sufficiently energetic charged particles or rediant energy travel through gases, liquids or solids. It is used in Ionizing radiation , Ionized water filter, Alkaline water ionizer and in others.

5. Biomolecules are biological molecule, that are produced by cells organic molecules especially macromolecules like carbohydrates, proteins in living organisms. All living things like bacteria, algae, plant and animals are made of similar macromolecules that are biomolecules. There are different types of biomolecules like small molecules include Lipids, fatty acid, Vitamins, Monomers etc. MS becoming an necessary field to analyze biomolecules. The desorption ionization based on the emission of pre-existing ions such as plasma desorption (PD), fast atom bombardment (FAB) or laser desorption (LD), allowed mass spectrometry for analyzing complex biomolecules. It includes Nucleic acid biomolecule, DNA biomolecules etc.

6.Genetic Disorders: it is caused because of abnormality in an individual's genome also caused by heredity. The abnormality range can be from minor to major. It causes by new changes in DNA. This create Single-gene problem. This also cause multifactorial and polygenic which cause heart disease or diabetes.

7. Combinatorial Chemistry includes large group of structural diverse compounds. This technique contain chemical synthetic method to prepare large number of compounds in a single process. It is used to synthesis small molecules and peptides. The methods of combinational chemistry are used outside chemistry too. It includes in drug discovery, dynamic chemistry and screening impact factor also.

8. Agro-Chemistry is the part of Chemistry and Biochemistry that is important in agricultural production. The aim of this chemistry is to relate plant and animal growth. Its another aim is to increase the fertility of soil. The important branch of this agro-chemistry is Chemurgy which is concerned chiefly with agricultural product as raw materials.

9. Bioanalysis covers the quantitative measurement of drug and their metabolites, concentrations etc. It measures the small molecule. Bioanalysis technique includes liquid chromatography–mass spectrometry, capillary electrophoresis–mass spectrometry, ultra-performance liquid chromatography etc. it is mainly focused on measuring small molecules of drugs. There are several international organizations are doing research on bioanalysis like European Bioanalysis Forum, Royal Netherlands Chemical Society.

10. Therapeutics is the response which is happen after treatment of any kind of therapy. It is the part of medicine concerned with the treatment of disease and the action of remedial agents.

11. Forensic Chemistry is the part of chemistry and it is a legal setting. This field involves the identification and quantitative analysis if scientific evidence. The forensic chemistry assists the identification of crime. The methods mainly used for forensic chemistry include HPLC, GCMS, Atomic absorption spectroscopy etc. Forensic toxicology is a part of Forensic chemistry which study on pharmacodynamics that what a substance does to a body.

12. Food technology is a scientific research for preservation of food. It is very helpful for food supply and that change the world. Developments in food technology is a big contribution for the whole world. Different process is including for this developments like Freeze-Drying, High temperature short time processing, Process optimization, Decaffeination etc. The food processing industries are involved in processes such as primary, secondary, processing, preservation, quality management, packaging, labeling.

13. Electrospray Ionization is the process which is used in mass spectroscopy to produce ion in electrospray. High voltage to apply in liquid to create an aerosol. It is used to produce ions from macromolecules. Mass spectroscopy using ESI is called electrospray ionization mass spectroscopy. It is a soft ionization technique. ESI is used to study protein folding and to test presence of nanoclusters.

14. Atmospheric pressure chemical ionization is an ionization process which is used in mass spectroscopy and in HPLC. The main uses of APCI is thermal stable samples with low to medium molecular weight, medium and high polarity.

15. Hyphenation is a separation technique which refer to combination of two or more techniques to separate chemicals from solutions. The main thing related to Hyphenation is Mass spectrometry, Electrochemical analysis, Hybrid techniques , etc.

16. Pharmaceutical Research is a relating to medicinal drugs and industries which discovers develops and produces drugs for uses. For making this it need variety of laws and regulation. Drug discovery, Drug development, pharmaceutical drugs is the part of Pharmaceutical research. Each Pharmaceutical companies are doing their research on different drugs to create something new.

17. Biomedical Research is the application of engineering principles and concepts of medicine and healthcare. It is a field that develops methods, tools. It is related to medical biological science. It has a different part like Tissue Engineering, Genetic Engineering, Pharmaceutical Engineering, Clinical Engineering. Clinical and Pre-clinical both research phase exists in Biomedical Research and is oriented towards a specific pharmaceutical purpose.

18. Post-translational modification is the enzymatic modification of proteins. This mainly happen in amino acid side chains. Some of them are consists of cleaving peptide bonds and some types are consequences of oxidative stress. PTM can be detected by different techniques like MS, Eastern blotting and Western blotting. It includes Post translational modification prediction, Post translational modification in eukaryotes etc.

19. Liquid–liquid extraction is a method to separate two different immiscible liquids based on their relative solubilities. LLE is possible in non-aqueous systems also as a system consisting of a molten metal in contact with molten salts. The solution which is to be extracted is called the feed, and the liquid with which feed is contacted is the solvent. In petroleum industry Extraction process is well used. Other application is in biochemical, pharmaceutical industries for antibiotics and protein recovery.

20. Chromatography and High Performance Liquid Chromatography (HPLC): Liquid chromatography-mass spectrometry analysis of small molecules from biofluids requires sensitive and robust assays. Because of the very complex nature of many biological samples, efficient sample preparation protocols to remove unwanted components and to selectively extract the compounds of interest are an essential part of almost every bioanalytical workflow. High-performance liquid chromatography (HPLC) is a separation technique that can be used for the analysis of organic molecules and ions. HPLC is based on mechanisms of adsorption, partition and ion exchange, depending on the type of stationary phase used. HPLC involves a solid stationary phase, normally packed inside a stainless-steel column, and a liquid mobile phase. Separation of the components of a solution results from the difference in the relative distribution ratios of the solutes between the two phases. HPLC can be used to assess the purity and/or determine the content of many pharmaceutical bioprocessing substances.

Sessions/Tracks

Track 1: Mass Spectrometry Significances

Mass spectrometry (MS) is feasibly regarded as the most important analytical spectroscopic tool of modern times. MS is a technique used to measure the mass of ions that are electrically charged species, derived from atoms or molecules. The fundamental atomic and molecular processes can be understood well by this technique and helps to control processes in chemical and biological industries, in diagnosing diseases, discovery of new drugs, protecting the environment and explore mysteries of nature. This particular track would evolve the significances of analysis of biomolecules and certain ionization techniques. This would also focus on the data analysis through softwares engaged in MS.

  • Analysis of Biomolecules
  • Data Analysis through Software
  • Ionization Techniques

Track 2: Recent Innovations in MS Application

MS technique has a blended feature in industrial and academic fields for routine and research purposes. Mass spectrometry has become an indispensable technique with a myriad of different applications in biology, chemistry, and physics and in clinical science and even in space exploration observing air quality manning space mission and then to examine the composition of planetary atmospheres. Due to its accuracy in speed and stupendous sensitivity, mass spectrometry has also been regarded as a paramount in many phases of drug discovery. The technique finds its applications in testing water quality or potential food contamination. Therefore, MS is becoming a very prominent figure in the wings of clinical and other research endeavors such as biomedical, petro products, space research, astrochemistry and geological ground.

  • Techniques in Petro Products
  • Methods for Space Research
  • Astrochemistry
  • Geological Research
  • Biomedical Research Analysis

Track 3: MS Opportunities in Life Sciences

MS on the basis of proteomics has become an epitome in the cellular and molecular life sciences which has been enabled by the 'soft ionization' techniques of electrospray and matrix-assisted laser desorption-ionization that allows the ionization and vaporization of thermally labile biomolecules. The instrumentation directed for proteomics research have led to innovative instrumentation designs and biochemical strategies in the large-scale identification and quantification of proteins, as well as in the characterization of their complexes and post-translational modifications. These comprehensive proceedings can decipher the pathophysiology of development in diseases at a molecular level and to monitor the individual response of lifestyle intervention through pharmacology. This technique evolves indispensable implications in several areas of research such as structural proteomics, metabolomics and lipids, post-translational modifications

  • Metabolomics and Lipids
  • Post-Translational Modifications
  • Structural Proteomics

Track 4: Recent Advances in LC-MS Principles and Applications

The LC-MS technology is a protocol replicating the use of HPLC where the components in a mixture are first separated individually followed by the procedure of ionization and then separating the ions on the basis of their mass/charge ratio by feeding those into an electron multiplier tube detector which eventually identifies and quantifies each ion. The ion is the potent source in MS analysis aiding efficiency in generation of ions for analysis. LC-MS has now became a routine technique for providing a simple and robust interface applying to a wide range of biological molecules by using of tandem MS and stabling isotope that allows highly sensitive and accurate assays. The major significance of this technology projects sensitivity, specificity and precision analysis done at molecular level. Some of these applications may be biochemical screening for genetic disorders and preluding the ideas of combinational chemistry and agro-chemistry.

  • Principles of LC-MS
  • Biochemical Screening for Genetic Disorders
  • Combinatorial Chemistry
  • Agro-Chemistry

Track 5: Recent Trends and Development in LC-MS

The use of LCMS has become a paramount in two dimensional hyphenated technology to be useful in a wide assortment of analytical and bioanalytical techniques of nucleic acids, amino acids, peptides, proteins, carbohydrates, lipids, and etcetera and in categorizing the field of genomics, proteomics, metabolomics, lipidomics. Current trends are may be gripped of mass analyzers, ionization protocols, fast LC–MS, LC–MALDI-MS, ion mobility spectrometry used in LC–MS, quantitation issues specific to MS and emerging mass spectrometric approaches which are complementary base in LC–MS are also discussed to focus on the recent innovations in LC–MS especially from the last decade and then to enlist mass spectrometers offered currently by main manufacturers for LC–MS and MALDI-MS configurations together with the technical specifications. The forthcoming supplements in LC-MS could be emphasized on Bioanalysis, Aspects in Clinical Chemistry, Qualitative and Quantitative Analysis of Compounds

  • Bioanalysis
  • New Aspects in Clinical Chemistry
  • Qualitative and Quantitative Analysis of Compounds

Track 6: Major challenges of LC-MS in Pharmacology and Drug Discovery

It is noticed that LC/MS system during the past 2 years has been used to quantify natural small molecules biologically.Numerous developments have been made in LCMS analysis such as phospholipids and drugs with respect to pharmacokinetics and pharmacodynamics studies interfering with the metabolism of sphingolipids. Simultaneous measurements of drugs with the levels of natural metabolites are designed to modify. The processes incorporated inLC-MS method development for the pharmacological studies includes three anti-cancer drugs (i.e., methoxyamine, fludarabine, and 6-benzylthioinosine). Some others being specific are tetra-enzyme cocktail utilizing for release of DNA adducts All these methods are applied to study the drug effect and drug mechanism through other integrated prospects like therapeutics and detection & determination of impurities

  • Therapeutics
  • Detection & Determination of Impurities

Track 7: LC-MS in Forensics and Toxicology

Liquid chromatography-mass spectrometry (LC-MS) after a prolong development has led to the introduction of some major interfacing techniques in the field of analytical toxicology and forensics Chemistry. Some of these LC-MS interfaces are legible in handling fragile species. This review is intended to present LC-MS on the applications of Forensics Chemistry and Toxicology by coupling with the techniques supplementing the evaluation of doping agents, drugs, forensic analysis, toxicity of compounds .Liquid chromatography-mass spectrometry (LC-MS) to forensic or clinical toxicology, or analytical methods are fostering technical improvements and to a decrease in the price of instruments. Most recent applications in forensic or clinical toxicology are proposed for typical applications in human toxicology for the determination of morphine metabolites with the perspectives concerning technical improvements in ionisation interfaces/sources or mass spectrometers, as well as in sample preparation and liquid chromatography techniques like Doping and Screening.

  • Applications in Forensics Chemistry
  • Toxicology and its evaluation in LCMS
  • Doping and Screening

Track 8: Development in Environmental and Food Sciences

The cruelest track of ecological problems is mutagenic pollution in the environment, and thereby the determination of mutagenic compounds in environmental samples is a crucial part. Mutagens found are polycyclic aromatic compounds, heterocyclic aromatic amine compounds, azo dyes, aldehydes and pesticides. Other advanced aspects for the current analysis in LC/MS are urinary metabolites of mutagens and DNA modification. The analysis made on the residues of pesticides in food has increasingly become an important task where the screening and controlling of the quality has to be very strict in order to safeguard the consumers’ health. One of the potent goals of food quality assurance is testing food for the residues and contaminants. Among chemical hazards the contaminants found in food with pesticides has been characterized as a source of many serious diseases. Consumption of food containing pesticide residues may cause cancer, malformations, and damage to the endocrine, nervous, and immune system. Liquid chromatography-mass spectrometry methods (LC-MS) are widely recognized as an ideal, highly specific, and extremely sensitive technique for testing these contaminated food products. This track would encounter the analysis and subsidiaries supplementing an enormous breakthrough in eradicating the loss of bad health by the following- analysis of natural substances, authenticity in food technology, detection of contaminants and prosperity of benign components.

  • Analysis of Natural Substances
  • Authenticity in food technology
  • Detection of Contaminants
  • Prosperity of Benign Components

Track 9: Opportunities and Advancements in LC-MS

LC-MS systems usually comprise of devices for the introduction of samples that require an interface for connecting the devices where an ion source would ionize samples. Electrostatic lens used for the implication of the generated ions, mass analyzer unit which separates the ions based on their mass-charge ratio and a detector unit for detecting the separated ions. LC–MS is also has a room in proteomics where components of a complex blend must be detected and identified. This approach to proteomics generally involves protease digestion and denaturation followed by LC–MS techniques with peptide mass fingerprinting or LC–MS/MS (tandem MS) to derive sequence of individual peptides. LC–MS/MS is the paramount for proteomic analysis of complex samples where peptide masses may overlap even with a high-resolution mass spectrometer. This particular session would emphasize on Electrospray Ionization (ESI), Atmospheric Pressure Chemical Ionization (APCI), Quantitative Analysis and Hyphenation

  • Developments in Electrospray Ionization(ESI)
  • Atmospheric Pressure Chemical Ionization(APCI)
  • Trace Quantitative Analysis
  • Hyphenation

Track 10: Scopes and Advancements in LC-MS

This hyphenated technique LC-MS plays a stupendous role in the environmental field for the determination of micro-pollutants. High performance liquid chromatography coupled to tandem mass spectrometry has implied that many environmental contaminants which are highly polar or nonvolatile or have a high molecular weight need to be analyzed or identified. In this track an overview is focused on the developments of liquid chromatography mass spectrometry applied to the analysis of the main classes of micro-pollutants in aqueous and solid environmental samples and other supplements in LC-MS system. In addition to these, certain amendments are also carried forward to pharmacological activity taking into consideration of consumption deriving from their use in human and veterinary medicine. Some of these developments may impact through the following- advancements in clinical research, enhanced protocols in principles of LC-MS, informatics tools

  • Advancements in Clinical Research
  • Enhanced Protocols in Principles of LC-MS
  • Informatics Tools

Track 11: Advanced Nanotechnology Implications in LC-MS

Nanoscale liquid chromatography coupled to tandem mass spectrometry has become an indispensable tool in the field of proteomics now-a-days. The advantages are grabbed with the sensitivity of nanotechnology over conventional LC-MS that allow the analysis of various peptide mixtures in limited situations. This approach gives a strong cation-exchange, sample enrichment, reversed-phase chromatography and nanospray ion trap mass spectroscopy with data dependent tandem mass spectrometry spectra acquisition. Nanocolumn liquid chromatography and largely synonymous capillary liquid chromatography (capillary LC) are the most recent results of this process where miniaturization of column dimensions and sorbent particle size play crucial role along with the advances in mass spectrometry that has really brought a breakthrough. Configuration of Nano LC-electrospray ionization mass spectrometry (LC-ESI-MS) has become a essential tool in bioanalytical chemistry that basically indulges in proteomics. This particular session includes the brief account on pharmaceutical and biomedical research, Nano-proteomic analysis and Nano-proteomic analysis.

  • Pharmaceutical and Biomedical Research
  • Nano-Proteomic Analysis
  • Amendments of Nanomaterials in LC-MS

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Date and Time

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Tin Shui Wai, New Territories

Hong Kong

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