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4th International Conference on Synthetic Biology and Tissue Engineering (...

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Holiday Inn Rome - Aurelia

Via Aurelia, Km 8,400

00165 Roma

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4th International Conference on Synthetic Biology and Tissue Engineering


About Conference

Conferenceseries Ltd International Conferences invites all the participants from all over the world to attend "4th International Conference on Synthetic Biology and Tissue Engineering" during June 11-12, 2018 at Rome, Italy, which includes prompt keynote presentations, Oral talks, Poster presentations and Exhibitions.

Tissue engineering is aimed mainly at producing anatomically and physiologically realistic replacements for normal human tissues. It is done either by encouraging cellular colonization of manufactured matrices or cellular recolonization of decellularized natural extracellular matrices from donor organs, or by allowing cells to self-organize into organs as they do during fetal life. For repair of normal bodies, this will be adequate but there are reasons for making unusual, non-evolved tissues (repair of unusual bodies, interface to electromechanical prostheses, and incorporating living cells into life-support machines).

Synthetic biology is aimed mainly at engineering cells so that they can perform custom functions: applying synthetic biological approaches to tissue engineering may be one way of engineering custom structures. The embryological cycle of patterning, differentiation and morphogenesis and review progress that has been made in constructing synthetic biological systems to reproduce these processes in new ways. The state-of-the-art remains a long way from making truly synthetic tissues, but there are now at least foundations for future work. Scientifically, the success of these endeavors is the ultimate proof that we know enough about cellular signaling pathways to harness them for our purposes. From a practical standpoint, targeted regulation of cell signaling paves the way to real cures of many disorders, genetic and acquired, where before we could only manage the symptoms using small molecules.

Objective:

Synthetic Biology and Tissue Engineering 2018 has the goal to fulfill the prevailing gaps in the transformation of this science of hope, to serve promptly with solutions to all in the need. International Conference on Synthetic Biology and Tissue Engineering 2018 will have an anticipated participation of 150+ delegates across the world to discuss the conference goal.

About Organizers

Conferenceseries Ltd International is one of the leading Open Access publishers and organizers of international scientific conferences and events every year across USA, Europe & Asia Conferenceseries Ltd has so far organized 300+ International Conferences across the World with 500+ peer-reviewed open access journals in basic science, health, and technology. Conferenceseries Ltd International is also in association with more than 1000 International scientific and technological societies and associations and a team of 30,000 eminent scholars, reputed scientists as editorial board members.

Scientific Sessions:
Synthetic Biology and Tissue Engineering-2018 to describe the use of engineered tissues to form biological systems with metazoan-like complexity. The increasing maturity of tissue engineering is beginning to render this goal attainable. As in other synthetic biology approaches, the perspective is bottom-up; here, the premise is that complex functional phenotypes (on par with those in whole metazoan organisms) can be affected by engineering biology at the tissue level. To be successful, current efforts to understand and engineer multicellular systems must continue, and new efforts to integrate different tissues into a coherent structure will need to emerge. The fruits of this research may include improved understanding of how tissue systems can be integrated, as well as useful biomedical technologies not traditionally considered in tissue engineering, such as autonomous devices, sensors, and manufacturing.

Synthetic Biology and Tissue Engineering -2018 will be a great platform for research scientists and young researchers to share their current findings in this field of applied science. The major scientific sessions in Synthetic Biology and Tissue Engineering -2018 will focus on the latest and exciting innovations in prominent areas of Systems biology and Synthetic biology research.



Sessions or Tracks

Sessions/Tracks

Conferences Series LLC invites all the participants from all over the world to attend 4th International Conference on Synthetic Biology and Tissue Engineering June 11-12, 2018 Rome, Italy which includes prompt keynote presentations, Oral talks, Poster presentations and Exhibitions.

Track 1: Systems and Synthetic Biology

Systems and Synthetic Biology is a relatively new field in biomedical research. It focuses on engineering new or modified signaling proteins to create desired signaling pathways in the cell. Every living cell is an extremely complex machine expressing thousands of different proteins. Due to superb regulation, many cells, such as photoreceptors and other neurons in vertebrates, can live for decades. Cells can also self-reproduce by division, where both daughter cells are perfectly viable. Natural selection (the “blind watchmaker”, to use Dawkins’ expression) spent hundreds of millions of year to achieve this perfection. Due to elucidation of the intricacies of cellular regulatory mechanisms we can now play evolution on our time scale: re-design proteins and signaling pathways to achieve our ends.


Track 2: Synthetic Biology

Synthetic biology is the convergence of advances in chemistry, biology, computer science, and engineering that enables us to go from idea to product faster, cheaper, and with greater precision than ever before. It can be thought of as a biology-based “toolkit” that uses abstraction, standardization, and automated construction to change how we build biological systems and expand the range of possible products. A community of experts across many disciplines is coming together to create these new foundations for many industries, including medicine, energy and the environment.


Track 3: Tissue Engineering

Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological tissues. Tissue engineering involves the use of a scaffold for the formation of new viable tissue for a medical purpose. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field in its own.


Track 4: CRISPR-Cas9 Genome Editing

CRISPR-Cas9 is a unique technology that enables geneticists and medical researchers to edit parts of the genome by removing, adding or altering sections of the DNA Sequence.It is currently the simplest, most versatile and precise method of genetic manipulation and is therefore causing a buzz in the science world.

The CRISPR-Cas9 system consists of two key molecules that introduce a change (mutation) into the DNA. These are an enzyme Called Cas9. This acts as a pair of ‘molecular scissors’ that can cut the two strands of DNA and a piece of RNA Called guide RNA (gRNA) which binds to DNA. The Cas9 follows the guide RNA to the same location in the DNA sequence and makes a cut across both strands of the DNA. At this stage the cell recognises that the DNA is damaged and tries to repair it.


Track 5: Computational Systems Biology

As name "Computational Systems Biology" reflects conviction that the investigation of biological systems is best drawn nearer by fusing numerous points of view. We unite assorted qualities of controls that supplement each other to disentangle the complexity of biology. The idea incorporates anatomy, physiology, cell and stem cell biology, molecular biology, developmental biology, biochemistry and biophysics. We work with animals, plants and microorganisms and our exploration traverses the levels of the organic chain of command from molecules to ecosystems. Our expansive scope of mastery incorporates: geneticists, paleontologists, physiologists, behaviorists, systematists, morphologists, microbiologists, bioinformatician, evolutionary biologists, ecologists, biophysicists and biotechnologists.


Track 6: Biomaterials in Tissue Engineering

Biomaterials play a pivotal role in field of tissue engineering. Biomimetic synthetic polymers have been created to elicit specific cellular functions and to direct cell-cell interactions both in implants that are initially cell-free, which may serve as matrices to conduct tissue regeneration, and in implants to support cell transplantation. Biomimetic approaches have been based on polymers endowed with bioadhesive receptor-binding peptides and mono- and oligosaccharides. These materials have been patterned in two- and three-dimensions to generate model multicellular tissue architectures, and this approach may be useful in future efforts to generate complex


Track 7: Scaffolds for Tissue Engineering

Tissue engineering along with regenerative medicine can be used to create ‘Scaffolds’ in the human body. These scaffolds are used to support organs and organ systems that may have been damaged after injury or disease. This is most commonly achieved through the use of stem cells. Stem cells are unique types of cells that are undifferentiated. So the main focus of creating these constructs is to be able to safely deliver these stem cells, and create a structure that is physically and mechanically stable so that these stem cells can differentiate. Scaffolds are of great importance in clinical medicine. It is an upcoming field, and usually associated with conditions involving organ disease or failure. It is used to rebuild organs and return normal function.


Track 8: Tissue repair and Regeneration

The term “repair,” when used in the context of the healing of damaged tissue, is defined as the restoration of tissue architecture and function after an injury. It encompasses two separate processes: regeneration and replacement. Regeneration refers to a type of healing in which new growth completely restores portions of damaged tissue to their normal state. Replacement refers to a type of healing in which severely damaged or non-re generable tissues are repaired by the laying down of connective tissue, a process commonly referred to as scarring. While a few types of tissue injury (such as minor paper cuts) can sometimes be healed in such a way that no permanent damage remains, most of our tissue repair consists of both regeneration and replacement. Tissue repair may restore some of the original structures of the damaged tissue (such as epithelial layers), but may also result in structural abnormalities that impair organ function (such as the scar formed in the healing of a myocardial infarction).


Track 9: Mammalian Synthetic Biology

Synthetic biology has pioneered transformative approaches that are affecting how scientists tackle key questions in mammalian cell biology. Synthetic biology techniques have wide-ranging applicability and commonly make use of genetic devices, or collections of genetic elements encoding particular functions, for probing key cellular mechanisms. Early success focused on engineered transcription-based regulatory systems primarily in bacteria. More recently, new endeavors have shifted to mammalian gene regulatory processes to allow flexible, precise, and comprehensive control over gene expression and cellular development. Novel and more complex genetic devices have been used to probe cellular mechanisms, including alternative splicing, RNAi, and epigenetics.


Track 10: Synthetic Bioengineering

Synthetic Bioengineering is the manipulation of the biological compounds varying their physical and chemical forms using engineering principles and techniques. Engineering is done at cellular and subcellular level i.e. molecular level. Bioengineering is the “biological or medical application of engineering principles or engineering equipment. Recently, the practice of bioengineering has expanded beyond large-scale efforts like prosthetics and hospital equipment to include engineering at the molecular and cellular level with applications in energy and the environment as well as healthcare


Track 11: Synthetic Biotechnology

Synthetic biotechnology involves the manipulation of biological compounds like integration of synthetic amino acids into proteins, DNA synthesis and manipulation using synthetic sequences, oligonucleotide synthesis, protein modification using synthetic compounds etc. the compounds produced synthetically are orthogonally integrated into cells which are chosen to provide suitable experimental strategy.



Track 12: Gene Therapy in Tissue Engineering

There are a large number of reports on gene therapy in tissue engineering, and these cover a huge range of different engineered tissues, different vectors, scaffolds and methodology. The review considers separately in-vitro and in-vivo gene transfer methods. The in-vivo gene transfer method is described first, using either viral or non-viral vectors to repair various tissues with and without the use of scaffolds. The use of a scaffold can overcome some of the challenges associated with delivery by direct injection. The ex-vivo method is described in the second half of the review. Attempts have been made to use this therapy for bone, cartilage, wound, urothelial, nerve tissue regeneration and for treating diabetes using viral or non-viral vectors. Again porous polymers can be used as scaffolds for cell transplantation. There are as yet few comparisons between these many different variables to show which is the best for any particular application. With few exceptions, all of the results were positive in showing some gene expression and some consequent effect on tissue growth and remodeling.



Track 13: Synthetic Genomics

Synthetic genomics is an early field of engineered science that uses parts of hereditary alteration on prior life frames with the plan of delivering some item or wanted conduct with respect to the living thing so made. Synthetic genomics joins strategies for the fake amalgamation of DNA with computational methods to plan it. These strategies permit researchers and specialists to build hereditary material that would be inconceivable or illogical to deliver utilizing more routine biotechnological approaches. For instance, utilizing manufactured genomics it is conceivable to outline and amass chromosomes, qualities and quality pathways, and even entire genomes


Track 14: Tissue engineering and Regenerative medicine

Tissue engineering is a branch of regenerative medicine, itself a branch of biomedical engineering. Tissue engineering and regenerative medicine are concerned with the replacement or regeneration of cells, tissues (the focus of tissue engineers) or organs to restore normal biological function.


Track 15: Bone Tissue Engineering

Bone tissue engineering is a complex and dynamic process that initiates with migration and recruitment of osteoprogenitor cells followed by their proliferation, differentiation, matrix formation along with remodeling of the bone. The regenerative potency of bone is due to bone morphogenetic proteins (BMPs) in the bone matrix. BMPs act via BMP receptors and Smads 1, 5 and 8 to initiate lineage of cartilage and bone. The homeostasis of tissue engineered bone and cartilage is dependent on the maintenance of extracellular matrix and biomechanics.


Track 16: Cartilage Tissue Engineering

Collagens are main protein components in natural cartilage, bone, and other connective tissue ECMs. They contribute to cell adhesion, proliferation and differentiation, 143 and, thus serve as one of the most common scaffold materials for cartilage tissue engineering.

\016 EMBL Heidelberg, Germany;Biotechnology Conferences Europe 2018;Conference on Biotechnology, Bioengineering and Synthetic Biology Zurich, Switzerland January 15 - 16, 2018; International Conference on CRISPR Technologies December 4-6, 2017 Raleigh, USA; Synthetic Biology and Gene Editing conference 4th-5th Dec 2017 at London, UK; Synthetic Biology and Natural Products Conference December 05-06, 2017 Cancun, Mexico


Track 17: Next Generation Sequencing

Next-generation sequencing alludes to non-Sanger-based high-throughput DNA sequencing technologies. Millions or billions of DNA strands can be sequenced in parallel, yielding considerably more throughput and minimizing the requirement for the fragment cloning techniques that are frequently utilized as a part of Sanger sequencing of genomes. DNA sequencing industry is sectioned into instruments and consumables, administrations, and workflow products.


Track 18: Synthetic Chemistry

Stem cells will be cells begin in all multi-cell organisms. They were detached in mice in 1981 and in people in 1998. In people there are a few sorts of stem cells, each with variable levels of strength. Stem cell treatments are a sort of therapy that brings new cells into grown-up bodies for conceivable treatment of cancer, diabetes, neurological disorders and other medical conditions. Stem cells have been utilized to repair tissue damaged by infection or age. In a creating embryo, stem cells can separate into all the specific cells ectoderm, endoderm and mesoderm, additionally keep up the ordinary turnover of regenerative organs, for example, blood, skin, or intestinal tissue.


Track 19: Stem Cell and Tissue Engineering

Natural cell phenotypes in tissues and organs are the result of stem cell differentiation at the embryonic stage of development. Although in vivo many natural biochemical/molecular biological determinants that instruct the direction of stem cell differentiation are well known (6, 7), very many cell types are also subject to native mechanical forces which also play a role in their phenotypic outcome. The source of stem cells may be either embryonic or adult (umbilical cord blood stem cells are generally classified as ‘adult’ though clearly a more appropriate term is sought). They should be either pluripotent, able to differentiate into cell types characteristic of any of the three developmental germ layers, or at least multipotent, capable of differentiating into varieties of an individual cell lineage.


Track 20: Bioreactors in Tissue Engineering

A bioreactor can be defined as a device that uses mechanical means to influence biological processes. In tissue engineering bioreactors can be used to aid in the in vitro development of new tissue by providing biochemical and physical regulatory signals to cells and encouraging them to undergo differentiation and/or to produce extracellular matrix prior to in vivo implantation. This chapter discusses the necessity for bioreactors in tissue engineering, the numerous types of bioreactor that exist, the means by which they stimulate cells and how their functionality is governed by the requirements of the specific tissue being engineered and the cell type undergoing stimulation.


Track 21: Angiogenesis & Vascularization

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. In precise usage this is distinct from vasculogenesis, which is the de novo formation of endothelial cells from mesoderm cell precursors, and from neovascularization, although discussions are not always precise. The first vessels in the developing embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood vessel growth during development and in disease.


Track 22: Cell Biology and Biophysics

Biophysics is branch that applies the principles of physics and chemistry and the methods of mathematical analysis and computer modeling to understand how biological systems work. It seeks to explain biological function in terms of the molecular structures and properties of specific molecules. An important area of biophysical study is the detailed analysis of the structure of molecules in living systems. The recent research areas are biophysical approaches to cell biology, cellular movement and cell motility, computational and theoretical biophysics, molecular structure and behavior of lipids, proteins and nucleic acids, molecular structure & behavior of membrane proteins, role of biophysical techniques in analysis and prediction, biophysical mechanisms to explain specific biological processes and Nano biophysics.


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