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4th International Conference on Enzymology, Lipid Science & Glycobiology (...

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Holiday Inn Atrium

317 Outram Road

Orchard City, Singapore

Singapore

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4th International Conference on Enzymology, Lipid Science & Glycobiology


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ConferenceSeries Ltd organises 1000+ Global Events every year on Clinical, Medicine, Pharma and Science & Technology every year across USA, Europe, Asia, Middle East, Australia and UK with support from 1000 more scientific societies and Publishes 700+ open access journals which contains over 100000 eminent personalities, reputed scientists as editorial board and organizing committee members.


Importance and Scope:

With the success of “3rd International Conference on Enzymology & Molecular Biology” in London, UK Conference Series Ltd is proud to host upcoming “4th International Conference on Enzymology & Lipid Science” during September 17-18,2018 Singapore. This is an excellent opportunity for the delegates from Universities and Institutes to interact with the world class Scientists. The conference revolves around the theme – “Novel Advancements in Enzymology and Lipid Science”.

The broad subject coverage of the Conference and its size provide an excellent setting for participants to gain valuable insight into progress in research areas beyond their own. In addition a range of special sessions aims to engage participants on broader issues such as teaching in the enzymology and molecular biology research.

The Enzymology Conference has a strong emphasis on support and inspiration for the next generation of scientists, along with early-career researchers, a Young Researchers Forum, and activities to encourage interaction with peers and experts.

Altogether this conference aims to be an extraordinary cross discipline gathering in the enzymology life sciences for research presentations, discussions, learnings, inspirations and encouragement with participants leaving with new research knowledge and ideas, and perhaps the beginnings of international collaborations and associations.

Lipid issue are the expansive term for variations from the norm of cholesterol and triglycerides. Lipid variations from the norm are connected with an expanded danger for vascular illness, and particularly heart assaults and strokes. Anomalies in lipid issue are a mix of hereditary inclination and in addition the way of dietary admission. Numerous lipid issue are connected with being overweight. Lipid issue might likewise be connected with different sicknesses including diabetes. There is gathering prove that administration of cholesterol and triglyceride issue is connected with the lessened danger for heart assaults and strokes.


Sessions/Tracks

ConferenceSeries Ltd gladly welcomes all the participants from all over the world to join the upcoming prestigious event “4th International Conference on Enzymology and Lipid Science" to be held during September 11-12, 2018 at Singapore City. The conference includes Keynote presentations, Oral/Poster presentations and Exhibitions.

  • Enzymology Congress 2018 mainly emphasizes on methods such as Biochemical processes, Bio molecular engineering, Immunoassays for protein detection, Mass spectroscopy & protein profiling, Membrane-lipid therapy and Polyunsaturated fatty acids (PUFA).


Track-1: Enzymology & Biochemistry

Enzymes are both macromolecular and micromolecular proteins and are found naturally. They are macromolecular biological catalysts and accelerate chemical reactions. Enzymology deals with the study of enzymes, their kinetics, structure, and function, as well as their relation to each other. Enzymes play a very important role in the world. They act as a catalyst for a chemical reaction, whether that reaction involves the execution of DNA for the purpose of cell repair or for the digestion of any types of meat as well as poultry. Biochemistry is the branch of science which deals with the chemical processes within and related to living organisms. It is a laboratory based science that combines both biology and chemistry. Biochemistry mainly focuses on processes that happen at a molecular level like inside our cells, studying components like proteins, lipids and organelles. It also looks at how cells communicate with each other. Biochemists should understand how the molecular structure relates to its function, and then allow them to predict that how the molecules will interact. Biochemistry covers a range of scientific disciplines, which includes genetics, microbiology, forensics, plant science and medicine.

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Track-2: Molecular Enzymology

Molecular enzymology is that branch of biochemistry which encircles or deals with the functional as well as the structural characteristics of the enzymes within a molecular level. Enzymes are globular proteins which play a very important role as a catalyst for any type of biochemical reactions. Molecular enzymology is based on designing and enzyme synthesis and high unmet medical needs are based on innovative drug targets. These works are based on innovative drug targets. Molecular Enzymology's interest include in all aspects related to enzymes like discovery of enzymes, structure of enzymes, enzyme mechanisms, cellular and metabolic functions of enzymes, discovery of drugs, biochemical aspects of enzymes, bioinformatics, computational analysis, studies for molecular modeling, newer methods in enzyme expression as well as purification, bio catalysis, bio molecular engineering, enzyme kinetics and enzyme inhibitors.

Track-3: Clinical Enzymology

Clinical enzymology deals with the measurement of enzyme activity for the diagnosis and treatment of diseases. Enzymes are macromolecular catalysts which increase the rate or velocity of physiologic reactions. Each and every reaction occurring daily in our body takes place with the help of an enzyme or the other. In general, most of the enzymes are present in cells at much higher concentrations than that in plasma. Measurement of these levels in plasma indicates whether their tissue of origin is damaged causing to the release of intracellular components into the blood. This forms the basis of what is called clinical enzymology. Thus we can say that clinical enzymology refers to measurement of enzyme activity for the diagnosis as well as the treatment of diseases.

Track-4: Structural Enzymology

Enzymes are the group of proteins which process cellular metabolism. They can affect a reaction either by catalysing or they can be used to reverse the reactions in bio-chemical pathways. Though enzymes have complex enzymatic structures, they undergo many changes which is very important for reactions and so enzyme structure is very much essential. There is always a specific enzyme for specific reaction i.e., reactions are enzyme specific in nature. Enzymes structures are made up of a special type of amino acids i.e., α amino acids which are linked together via an amide (peptide) bond in a linear chain. This is the primary structure and the resulting amino acid chain is called a polypeptide chain or rather a protein.

Track 5: Soil Enzymology

Enzymes are the vital activators in life processes, likewise in the soil they are known to play a substantial role in maintaining soil health and its environment. Soil enzymes are critically important to the functioning of the soil. Soil enzymes are the product of soil microorganisms and are the drivers for biogeochemical cycling in soils. Soil enzymes are also involved in remediation of contaminated soils. As a result, soil enzymes have been considered indicators for soil ecosystem health. The enzymatic activity in the soil is mainly of microbial origin, being derived from intracellular, cell-associated or free enzymes. A unique balance of chemical, physical, and biological (including microbial especially enzyme activities) components contribute to maintaining soil health. Evaluation of soil health therefore requires indicators of all these components. Healthy soils are essential for the integrity of terrestrial ecosystems to remain intact or to recover from disturbances, such as drought, climate change, pest infestation, pollution, and human exploitation including agriculture. Deterioration of soil, and thereby soil health, is of concern for human, animal, and plant health because air, groundwater, and surface water consumed by humans, can be adversely affected by mismanaged and contaminated soil.

Track 6: Enzyme Kinetics

Enzyme kinetics deals with the study of the chemical reactions that are catalyzed mainly by the enzymes. In enzyme kinetics, the rates of the reaction are measured and the effects of varying the conditions of the reaction are studied. Studying the kinetics of an enzyme in this way can reveal the catalytic mechanism of that particular enzyme as well as its role in metabolism, how its activity is being controlled, and how a drug might inhibit that enzyme.

Track-7 Enzymology in Drug Discovery

Enzymes are the macromolecular and micromolecular proteins in the drug design that act as drug targets for the diseases in the process of discovery of drugs as well as its development. There are a number of drug targets which are involved in the designing of the drugs. Drug target is a nucleic acid or a protein whose activity can be modified by a drug itself. The drug can be a chemical compound with a small molecular weight or a biological compound, such as an antibody or a recombinant protein. The drug target should be effective in the disease by relevant in vitro or in vivo models and analysis.

Track 8: Enzyme Toxicology

Enzyme Toxicology is unremarkable, except the potential irritating effects usually associated with some proteases at high concentrations, and the allergic effects of enzymes. Like anything one is exposed to, the dose makes the poison; thus, with certain enzymes, a sufficient excess in exposure can lead to irritation. Enzymes are like the majority of food proteins so that oral exposure to the gut is entirely without effect, except perhaps at very high, unrealistic, exposure levels

Enzymes have been evaluated for genotoxic effects Nevertheless, enzymes are not mutagenic in the standard screening assays used in genetic toxicology, specifically the Ames test, and are not clastogenic in chromosome aberration tests. Repeated exposure studies on a number of enzymes have been completed. Most often this has been done in relation to enzymes to be used in foodstuffs and so exposure has been carried out via the oral route.

Track-9: Enzymology & Proteomics

Proteomics is the large-scale study related to proteins, mainly their structures and functions. Proteins are the vital parts of all the living organisms, as they form the main components of the physiological metabolic pathways of the cells. The term proteomics was first coined in the year of 1997 to make an analogy with the term genomics, which again deals with the study of the genome. The word proteome is a combination of protein and genome together. The proteome can be said as the entire set of proteins, which are produced or modified by an organism or a system.

Track-10: Computational Enzymology

Molecular simulations and modelling means altering the science of enzymology. Computational enzymology is a rapidly developing area, and is studying the theories of catalysis, challenging 'textbook' mechanisms, and also identifying the novel catalytic mechanisms. Also increasingly, modelling is contributing directly towards the experimental studies of the enzyme-catalysed reactions. Potential practical applications in this area include interpretation of the experimental datas, catalyst design and also drug development.

Track 11: Enzyme Nanotechnology

The nanomaterials possess ideal characteristics to equilibrate principal factors which determine biocatalysts efficiency, including specific surface area, mass transfer resistance and effective enzyme loading. This review presents the current scenario and techniques in enzyme immobilization. Some methods are used which are efficient to combine proteins/enzymes with nanoparticles. Immobilization process is to optimize the operational performance of an enzyme for industrial applications. So far different matrices have been described in the literature to improve the performance of the immobilized enzymes. With the advent of nanotechnology, the nanomaterials because of their unique physico-chemical properties constitute novel and interesting matrices for enzyme immobilization.

  • Enzyme nanoparticles
  • DNA nanotechnology
  • Nanotechnology products
  • DNA microarray
  • Nanopolymers
  • Nanotechnology in targeted drug delivery
  • Immobilization using nanoparticles
  • Nanotechnology enabled enzyme activity

Track-12: Industrial Applications of Enzymology

Enzymes are used nowadays in chemical industries and for some industrial purposes where extremely specific catalysts are required for industrial uses. Enzymes in general are rare in number of reactions they have evolved to catalyse and also by the lack of stability in organic solvents and at very high temperatures. Thus, protein engineering is an active an advanced area of research which includes attempts for creating new enzymes with novel properties. These efforts have begun to be successful, and a few enzymes have now been designed to catalyse reactions that do not occur naturally. Enzymes are usually macromolecular and micromolecular protein molecules that manipulate the other molecules i.e., the enzymes substrates. These target molecules binds up to the active site of an enzyme and are thus converted into products via a series of steps which are combined known as the enzymatic mechanism.

Track-13: Enzymology & Thermodynamics

In the presence of an enzyme, the reaction runs in the same direction as it would run without an enzyme, but just more quickly. The reaction rate is dependent on the activation energy which is needed to form the transition state which then transforms into products. Enzymes increase the reaction rates by decreasing the transition state energy. First, binding forms an enzyme-substrate complex (ES) with low energy. Secondly the transition state is stabilized by the enzyme such that it requires lesser energy to achieve compared to the uncatalyzed reaction (ES‡). Finally the enzyme-product complex (EP) gets dissociated to release the products.

Track-14: Enzymology in Food Processing & Technology

Food enzymology deals with all the aspects of the enzymology which are related to the food systems. The basic aspects of the food enzymology are the methods for measuring the enzyme activities; extraction of the enzymes from microbial, plant and animal systems; methods of purification of enzyme as well as its characterization; and regulation of enzymatic activities by activators, inhibitors, and via covalent modification.

Track-15: Lipids in Molecular Medicine

Clinical drugs which communicate with the lipids of membrane and which alter the composition of cell membranes can also change their localization and the activity of the membrane proteins. Several drugs which are used to fight against cancers, cardiovascular diseases, obesity and other pathologies, determine the structure of lipid in plasma membrane and they produce a an alteration in the localization and activity of the signalling proteins. The recent studies have caused to identify the specific disease-provoking gene mutations and have led to improve the clinical and laboratory treatments, and prenatal diagnosis in lipid related diseases.

Track 16: Lipid and Lipoprotein Metabolism

The total cost of decreasing low-density lipoprotein generally includes the costs of physician services, case finding and monitoring, dietary and exercise modifications, medications, and also treating the side effects. The cost of treatment-related appointments follow-up or varies by type of provider, location, and practice setting. The annual cost of statin drugs to reduce low-density lipoprotein cholesterol levels can range from $1,082 to $1,543 per year. Although the cost of decreasing the low-density lipoprotein cholesterol levels can be high, but it is much lower than the direct and indirect costs of cardiovascular disease research.

Track 17: Protein-Lipid & Lipid- Lipid Interactions

Lipid microarrays always give a learning base to the human lipidome. Exogenous types of fat are transported from the digestive system to the liver. After passing in to the circulatory system the chylomicrons are hydrolyzed by the lipoprotein lipase which are endothelial-enslaved. The liver uses the exogenous type of fat and can discharge surplus lipids by means of VLDL into the blood. The VLDL leftovers which are remaining can either be taken up into the liver or are hydrolyzed into LDL. Both these types of Hypercholesterolemia are the most fluent and have significant danger elements for arteriosclerosis.

Track 18: Lipids and Bioenergy

Fossil fuels are the life and blood for our society and for many others around the world. The environmental pollution due to the use of fossil fuels as well as their gradual depletion make it necessary to find an alternative energy and chemical sources that are environment friendly and also at the same time renewable in nature. Waste lipids are ideal the potential substrates for the production of biogas, since theoretically more methane can be produced by this process, when compared with proteins or carbohydrates. First step includes the hydrolysis of complex organic polymers into monomers by extracellular enzymes which are produced by the fermentative class of bacteria. Proteins are decayed to amino acids, carbohydrates into soluble sugars and lipids to glycerol. Lipid hydrolysis is actually faster than hydrolysis of protein or carbohydrate, and are thus considered to be a rapid process in anaerobic digestion.

Track 19: Lipids: Nutrition and Health

Lipids play a huge role in the normal functioning of the body and act as structural building material of all cell membranes and organelles. They provide energy for all the living organisms and provide almost thrice the energy content as compared to carbohydrates and proteins on a weight basis. They function as molecular messengers in the body. Lipids are also called biomarkers of disease and are involved in several pathological conditions. Some of the fatty acids need to be taken in diet include essential fatty acids (EFAs), linoleic acid (LA), and a-linolenic acid (LNA). DHA again is a daily requirement for normal neural and retinal development for the infants and young children.

Track 20: Glycobiology in Lipid Science:

Glycan’s are saccharides that can be linked to a variety of biological molecules through an enzymatic process called glycosylation to elevate their function of the four fundamental building blocks of life, proteins, carbohydrates (glycan’s), lipids and nucleic acids. Glycan’s have received the least attention from researchers. Glycan’s are found in Achaea, bacteria and eukaryotes, and their diverse functions contribute to physical and structural integrity, extracellular matrix formation, signal transduction, protein folding and information exchange between cells. The glycan components of these means can be more important to determine the biological activity and therapeutic ability. Biochemistry and Glycochemistry possess a multidisciplinary study of carbohydrate-binding proteins, glycolipids and some other plants protein that are capable of interacting with endogenous or foreign molecules.

We are sure Enzymology 2018 will be an incredible open door for the global group to trade thoughts and add to a typical vision for future research and prompts collaboration among researchers taking an interest.


Track 21: Glycoinformatics

Glycoinformatics is a presently new branch of bioinformatics that deals with the study of carbohydrates. It broadly includes database, software, and algorithm development for the study of carbohydrate structures, glycoconjugates, enzymatic carbohydrate synthesis and degradation, as well as carbohydrate interactions. Primitive usage of the term does not presently include the treatment of carbohydrates from the more well-known nutritive aspect.

Our Conference will provide a perfect platform addressing:

Laudable talks by the top-notch of the global scientific community

Sterling workshop sessions

Remarkable Awards and Global Recognition to meritorious Researchers

Global Networking with 50+ Countries

Novel Techniques to Benefit Your Research

Global Business and Networking Opportunities

Exquisite Platform for showcasing your products and International Sponsorship


Market Analysis

Summary:

Enzymology implies the study of enzymes and their structures. The reports in this section analyses the global enzymology market by application, equipment, tools, methodologies, software, and services. The application segments for instance hold the markets for enzymology based diagnosis & therapy; while the equipment segment covers markets for technologies such as microarrays, Ultrasonic processing, and Gel electrophoresis. Drug discovery forms the highest revenue-generating application market of enzymology. These reports show us the latest forecasted revenues of all the market segments and also provide the exhaustive analyses of current trends, market, growth strategies, and opportunities that are adopted by the key market players. Lipid disorders are the broad term for abnormalities of cholesterol and triglycerides. Lipid abnormalities are associated with an increased risk for vascular disease, and especially heart attacks and strokes. Abnormalities in lipid disorders are a combination of genetic predisposition as well as the nature of dietary intake. Many lipid disorders are associated with being overweight. Lipid disorders may also be associated with other diseases including diabetes, the metabolic syndrome (sometimes called the insulin resistance syndrome). There is accumulating evidence that management of cholesterol and triglyceride disorders is associated with the reduced risk for heart attacks and strokes. This is especially true in patients seen by endocrinologists who have diabetes mellitus or other problems associated with obesity.


Importance & Scope:

Enzymology is a new technology that is growing rapidly due to its higher applications in a lot of fields and due to having bright and clear future vision. A most exciting development over the last years is the application of genetic engineering techniques in enzymology. There are a number of properties which may be improved by genetic engineering including the kinetics of the enzyme the ease of downstream processing & various safety aspects. Enzymes from dangerous or unapproved microorganisms and from slow-growing plant or animal tissue can be cloned into high production microorganisms. New enzyme structures can be designed and then produced in order to improve on existing enzymes or create new activities. Elevated total cholesterol is most commonly a problem in patients who have elevated LDL cholesterol levels. Moderate elevations of LDL cholesterol are more common. These moderate elevations are still associated with heart disease risk. There are well established standards for what the targets of LDL cholesterol should be based on risk adjustment profiles. For example, young people with no heart disease risk factors have higher LDL cholesterol targets than patients who have diabetes or established heart disease. Hypertriglyceridemia is associated with increased heart disease risk. Hypertriglyceridemia is commonly associated with obesity and diabetes mellitus. The medications used for treating triglycerides are often different than those used to lower LDL cholesterol. Treatment of contributors to high triglycerides including reduction in body weight and the management of diabetes mellitus are also important. Some medications used to lower blood sugar will also have a favorable effect on triglycerides. Isolated low cholesterol, low HDL cholesterol is quite uncommon. Most of the time low HDL cholesterol is associated with high triglycerides. It is well known that low HDL cholesterol contributes to heart disease risk. Exercise is important in helping to raise HDL cholesterol.

Why Singapore?

SINGAPORE, known as “the LION city,” becomes a favorite destination because it is a global city and is a densely populated island with tropical flora, parks and gardens. Singapore is a global commerce, finance and transport hub.

Singapore is considered as an important center for higher education and harbors, healthcare, well reputed and prestigious colleges and Universities. Singapore conferences indeed play a vital role in promoting scientific information and ideas all over the world. It can be considered as a suitable medium for the relocation of valuable knowledge about research and novel advancements worldwide. The conferences taking part here would promote a variety of scientific ideas among contenders belonging to diverse areas of science and technology.

Apart from this, Singapore has been set aside for parks and natural reserves. The network of natural reserves, parks, park connectors, natural ways, tree-lined roads and other natural areas have enhanced the sense of green space in the city which will keep you busy for weeks. Singapore has a tropical rainforest climate with no distinctive seasons, uniform temperature, pressure, high humidity and abundant rainfall. Sentosa, Singapore Flyer, Universal Studios Singapore, Night Safari Singapore, Singapore Botanic Gardens, Jurong Bird Park, Singapore Zoo, Sri Mariamman Temple, Pulau Hantu famous for its rich coral reefs and Peranakan Museum are some of the points of interest in Singapore. A splendid location, life expectancy, quality of life, personal safety and housing that is unsurpassed for its livability makes Singapore a city to visit and remember.


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Holiday Inn Atrium

317 Outram Road

Orchard City, Singapore

Singapore

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