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2018 Neurodevelopmental Disorders Symposium

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Joseph B. Martin Conference Center

77 Avenue Louis Pasteur

Boston, MA 02115

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On Monday, October 22, 2018 the Translational Neuroscience Center (TNC) at Boston Children’s Hospital, in collaboration with Massachusetts General Hospital and Massachusetts Institute of Technology, will host the fourth Boston-wide Neurodevelopmental Disorders Symposium in the Joseph B. Martin Conference Center at Harvard Medical School. This symposium will include a Case Presentation on the Use of Genetic Technology to Guide Care, a Panel Discussion on the Readiness of Biomarkers for Clinical Trials, and sessions encompassing Biomarkers in Clinical Trials and Genetic Technology in Neurodevelopmental Disorders.

This conference, sponsored by the Anne and Paul Marcus Family foundation, is open to scientists and physicians from academia, the pharmaceutical and biotechnology industries, disease-based foundations, and the government and will include guest speakers and a poster session for graduate students and post-doctoral fellows.


Event Co-Chairs:

Mustafa Sahin, MD, PhD - Boston Children's Hospital
Jordan Smoller, MD, ScD - Massachusetts General Hospital
Mriganka Sur, PhD - Massachusetts Institute of Technology


Event Agenda:

8:00 am Registration & Continental Breakfast

8:45 am Welcoming Remarks
Mustafa Sahin, MD, PhD
Rosamund Stone Zander Chair
Professor of Neurology, Harvard Medical School
Director, Translational Neuroscience Center and Translational Research Program, Boston Children’s Hospital

8:55 am Introduction of Morning Speakers
Mriganka Sur, PhD
Paul E. and Lilah Newton Professor of Neuroscience
Director of the Simons Center for the Social Brain,
Massachusetts Institute of Technology

9:00 am Session 1: Emerging Biomarkers for Clinical Trials

Biomarkers of Immune Dysfunction in Autism Spectrum Disorder
Christopher J. McDougle, MD
Director, Lurie Center for Autism, Massachusetts General Hospital For Children
Nancy Lurie Marks Professor of Psychiatry, Harvard Medical School

9:35 am Research and Clinical Utility of Wearable Biosensors in NDD
Matthew S. Goodwin, PhD
Associate Professor and Director, Computational Behavioral Science Laboratory, Northeastern University
Visiting Associate Professor, Department of Biomedical Informatics,
Harvard Medical School

10:15 am Coffee Break

10:30 am EEG Biomarkers for Trials: Evidence from ABC-CT Interim Analyses
James C. McPartland, PhD
Director, Yale Developmental Disabilities Clinic
Associate Professor of Child Psychiatry and Psychology, Yale Child Study Center

11:05 am Case Study: Evolving Genetic Technology Guiding Clinical Care

Parents: David and Trista Collins - Parents of Kayla
Clinician: Lisa Prock, MD, MPH – Associate Chief, Developmental Medicine Center,
Boston Children’s Hospital

12:05 pm Box Lunch and Poster Session

1:30 pm Introduction of Afternoon Speakers
Jordan Smoller, MD, ScD
MGH Trustees Endowed Chair in Psychiatric Neuroscience
Professor of Psychiatry, Harvard Medical School
Director, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital


1:35 pm Session 2: Genetic Technology in Neurodevelopmental Disorders

SPARKING new paradigms in translational autism research stratified by genetics
Wendy K. Chung, MD, PhD
Kennedy Family Professor of Pediatrics and Medicine, Columbia University

2:10 pm Exploring Developmental Brain Disorders in 50K Exomes from a Health System Cohort
Christa L. Martin, PhD, FACMG
Professor and Director, Autism & Developmental Medicine Institute, Geisinger

2:45 pm Coffee Break

3:00 pm Panel Discussion: Readiness of Biomarkers for Clinical Trials

Mustafa Sahin, MD, PhD
Director, Translational Neuroscience Center, Boston Children’s Hospital

Thomas Frazier II, PhD
Chief Science Officer, Autism Speaks

Mark F. Bear, PhD
Picower Professor of Neuroscience, The Picower Institute for Learning and
Memory Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology

4:00 pm Keynote Speaker

Clinical Trials in Autism: Lessons Learned
Paul Wang, MD
Clinical Research, Simons Foundation
Associate Clinical Professor of Pediatrics, Yale University School of Medicine

5:00 pm Closing Remarks & Adjourn
Mustafa Sahin, MD, PhD
Rosamund Stone Zander Chair
Professor of Neurology, Harvard Medical School
Director, Translational Neuroscience Center and Translational Research Program, Boston Children’s Hospital

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Joseph B. Martin Conference Center

77 Avenue Louis Pasteur

Boston, MA 02115

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