€750

2-Day PK-Sim & MoBi workshop on PBPK and PBPK-based QSP

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Pharmacy Hall

20 N Pine St

Baltimore, MD 21201

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Description

esqLABS, in collaboration with the University of Maryland, is running a two-day hands-on PK-Sim® & MoBi® workshop on PBPK and PBPK-based QSP on Saturday and Sunday 16th and 17th of March 2019 (post ASCPT) at the University of Maryland in Baltimore, MD (near Washington, DC). The workshop covers the basics of PBPK and concepts and application of combining PK-Sim, MoBi and R to build your very own digital platforms for the prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic. During hands-on exercises you will learn how to:

  • Build a PBPK model in PK-Sim and compare to observed data
  • Learn how to consider age-dependency in drug PK in PK-Sim (Pediatrics and Geriatrics)
  • Conduct population simulations in PK-Sim and MoBi
  • Learn how to model drug-drug interactions in PK-Sim (DDI)
  • Integrate mechanism-based pharmacodynamics in MoBi
  • Conduct parameter identifications in PK-Sim and MoBi
  • Simulate and analyze your PBPK-QSP model in R

This workshop will be held by the consultants and scientists from esqlabs GmbH with extensive experience in the use of PK-Sim® & MoBi® in all application areas.

While the workshop does not require any prior experience with PK-Sim® & MoBi®, many topics will be of interest even for advanced users.


AGENDA

As use-cases for above learnings, we will develop PBPK models for small molecules and biologics and a PB-QSP model for naked antibody pre-treatment (nAb) for antibody-drug conjugates (ADC) treatment of tumor growth, in detail (preliminary agenda):

Agenda

PREPARATION

  • BRING YOUR OWN LAPTOPS! We will be doing hands-on work!
  • To download the software, please click here
  • Download & install the R distribution (Ver 3.5+) from here
  • Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
  • For starters, please check out the tutorial site (videos & hands-on) here

Visit our News & Events Section for info on additional workshops in the future and news on our future developments in physiologically-based quantitative-systems-pharmacology.


Best Regards,

Stephan Schaller
(Managing Director, esqLABS GmbH)

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Pharmacy Hall

20 N Pine St

Baltimore, MD 21201

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